2 projets européens trouvés
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TERMINÉ
Self-Modulating Neurons in the Cerebral Cortex: From Molecular Mechanisms to Cortical Network Activities (CORTEXSELFCONTROL)
Date du début: 1 oct. 2008, Date de fin: 31 mars 2014,
"In the mammalian brain, the neocortex is the site where sensory information is integrated into complex cognitive functions. This is accomplished by the activity of both principal glutamatergic neurons and locally-projecting inhibitory GABAergic interneurons, interconnected in complex networks. Inhibitory neurons play several key roles in neocortical function. For example, they shape sensory recep ...
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TERMINÉ
“Linking dendritic mRNA metabolism to neuronal functions and disorders” (dendritic mRNAs)
Date du début: 1 févr. 2009, Date de fin: 31 janv. 2013,
Synaptogenesis and synaptic plasticity rely on protein synthesis, in particular on localized translation within dendrites. The aim of my project will focus on investigating the multiple and overlapping molecular mechanisms that contribute to fine-tuning the expression of dendritic mRNA at synapses. In my previous work, I have identified a novel regulatory pathway that involves splicing and modulat ...
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