4 projets européens trouvés
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TERMINÉ
ASSET: Analysing and Striking the Sensitivities of Embryonal Tumours (ASSET)
Date du début: 1 nov. 2010, Date de fin: 30 avr. 2016,
Cancer is hallmarked by multiple genetic aberrations that lead to a functional derangement of cellular signalling networks. Embryonal tumours (ETs) comprising neuroblastoma, medulloblastoma and Ewing sarcoma, occur early in life, and thus may reveal pathogenetically relevant lesions clearer than adulthood tumours which carry passenger mutations accumulated during life. ASSET will exploit this fact ...
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20
Participants partenaires
TERMINÉ
HEMatopoietic cell IDentity : genetic and epigenetic regulation in normal and malignant hematopoiesis (HEM_ID)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,
In hematopoiesis, failure to maintain homeostasis and regenerative functions result in a multitude of hematological malignancies, including myelodysplastic syndromes, lymphomas and leukemias, that represent a medical challenge and a large socioeconomic burden because of the large number of affected patients of all age groups. Although hierarchical organization of the hematopoietic system has been ...
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12
Participants partenaires
TERMINÉ
"Small Molecule Antagonists of chromatin modifying enzymes for Regulation of Transcription, proliferation and differentiation" (SMART)
Date du début: 1 août 2008, Date de fin: 31 juil. 2011,
"Chromatin modifying enzymes play important roles in the regulation of gene expression, the establishment and maintenance of distinct cell types during development and the control of cellular proliferation. All of these features make them interesting targets for small molecule inhibitors that can function as probes for basic biological questions but also as lead compounds for drug development. Ind ...
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1
Participant partenaire
TERMINÉ
Dissecting pathogen recognition complexes of Toll-like receptors: hunting for new co-receptors and ligands (TolLiCoR)
Date du début: 1 août 2008, Date de fin: 31 juil. 2010,
Toll-like receptors (TLRs) are trans-membrane proteins that recognize pathogen associated molecular patterns (PAMPs) and subsequently induce an intracellular signaling cascade that triggers the activation of transcription factors which initiate the expression of host defense proteins. Ten human, structurally highly conserved TLRs have been identified and assigned to structurally very dissimilar li ...
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