5 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Mitochondrial Medicine: developing treatments of OXPHOS-defects in recombinant mammalian models (MITCARE)
Date du début: 1 juil. 2013, Date de fin: 30 juin 2018,
Mitochondria are the major source of ATP, synthesized by the mitochondrial respiratory chain (MRC) through the process of oxidative phosphorylation. ATP deficiency leads to cellular dysfunction and ultimately death. In mammals, 13 mitochondrial DNA (mtDNA)-encoded subunits interact with over 70 nuclear-encoded subunits to form four of the five MRC complexes. Many additional factors are essential f ...
Voir le projet
3
Participants partenaires
TERMINÉ
Defining the role of xeno-directed and autoimmune events in patients receiving animal-derived bioprosthetic heart valves (TRANSLINK)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
TRANSLINK is a project devoted to assessing the mid-to long-term risk factors and improve the outcome of animal (bovine/porcine)-derived Bioprosthetic Heart Valve (BHV) implants. 300,000 patients/year benefit from BHV, a major healthcare problem (second most frequent cardiac surgery). BHV clinical outcome suffers from late dysfunctions restricting their application to older recipients. Based on a ...
Voir le projet
14
Participants partenaires
TERMINÉ
Macroencapsulated Porcine Pancreatic Islets to cure Diabetes Mellitus type 1/2 (XENOISLET)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
During the last five years, within the EU FP6 Integrated Project XENOME (LSHB-CT-2006-037377), we have convincingly demonstrated in primates that a complete control of induced type 1 diabetes is routinely obtained for 6/8 months after transplantation of subcutaneous alginate macroencapsulated porcine islets xenograft without the use of any immunosuppression. In order to improve the function of pig ...
Voir le projet
5
Participants partenaires
TERMINÉ
EpiHealthNet
Date du début: 1 mai 2013, Date de fin: 30 avr. 2017,
Scientific evidence clearly indicates that ageing and health in adult life is programmed by genetic and epigenetic mechanisms early in life.Developmental plasticity in response to the environment, including nutrient availability, of mammalian embryos indicates the capacity fornewly emerging embryonic and extraembryonic cell lineages to initiate compensatory responses which may attune nutrient deli ...
Voir le projet
9
Participants partenaires
TERMINÉ
Optimisation of early reproductive success in dairy cattle through the definition of new traits and improved reproductive biotechnology (FECUND)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2017,
"Good fertility is essential for the sustainability of livestock production. Of all livestock sectors, fertility of dairy cattle is raising the greatest cause for concern. Cow fertility has declined, particularly in Holstein cattle, from 80% pregnancy to first service 20 years ago to less than 40% today. Poor fertility is one of the main reasons for early culling, such that modern dairy cows compl ...
Voir le projet