Plus de 40 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,
Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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44
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TERMINÉ
Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery (ULTRA-DD)
Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,
ULTRA-DD (Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery) will be an European-wide, highly collaborative and inclusive consortium, to validate new targets for drug discovery by (1) generating high quality research tools, with an emphasis on chemical probes; (2) generating the chemical probes in the most cost-effective manner, using structure-guided methods and harne ...
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10
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TERMINÉ
Standardization and Development of Assays for Assessment of Influenza Vaccines Correlates of Protection (FLUCOP)
Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,
Background: Influenza viruses cause annual epidemic and occasional pandemics, both of which induce significant morbidity and mortality. Influenza infections affect all age groups but children and adults over the age of 65 are at most risk of developing severe disease.Vaccination is the most effective approach to reduce the impact of annual influenza outbreaks and potential pandemics, however, the ...
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26
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TERMINÉ
European Gram Negative Antibacterial Engine (ENABLE)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2020,
The intensive use and misuse of antibiotics has resulted in some level of antibiotic resistance in essentially all human bacterial pathogens. There is a growing concern that the loss of therapeutic options will present us with a post-antibiotic era where present and future medical advances are negated. Resistant bacteria dramatically reduce the possibilities of treating infections effectively, a ...
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42
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TERMINÉ
European Prevention of Alzheimer’s Dementia Consortium (EPAD)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,
Background:The secondary prevention of Alzheimer’s dementia (AD) is achievable if we can identify individuals at risk of disease progression defined by biomarker evidence of AD pathology and no or only minimal clinical symptoms and engage them in a standing adaptive clinical trial, of the highest quality, testing multiple interventions. To achieve this, EPAD will also provide the analytical infras ...
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40
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TERMINÉ
Why do cancers occur where they do? A genetic and evolutionary approach (EVOCAN)
Date du début: 1 sept. 2014, Date de fin: 31 août 2019,
"Tumorigenesis is a form of somatic evolution, a topical subject given the advent of cancer genome sequencing. However, we contend that some features of Darwinian evolution have been neglected when cancer is studied, as have some aspects of evolution that are special to cancers. For example, tumours comprise an expanding population of cells, cancers must occur within a normal human lifespan, and g ...
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1
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TERMINÉ
Parton Distributions in the Higgs Boson Era (PDF4BSM)
Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,
"With the recent discovery of a Higgs-like particle at the Large Hadron Collider (LHC), particle physics has entered a completely new era. The central goal for high energy physics in the following years will be the detailed determination of the properties of this new particle, in particular checking its consistency with the Standard Model Higgs boson hypothesis, and to further explore the highest ...
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1
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TERMINÉ
The Proteolytic Machinery of the Plant Apoplast: from Basic Understanding to Improved Recombinant Protein Production (GreenProteases)
Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,
The plant proteolytic machinery involves over 700 proteases that control the (in)activation of proteins. Surprisingly, although every protein is regulated by proteolysis, only very few natural substrates of plant proteases have been identified, and the diverse roles of e.g. secreted proteases are still poorly understood. These questions have become even more urgent since glyco-engineered plants ar ...
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1
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TERMINÉ
Unravelling the genetic influences of reproductive behaviour and gene-environment interaction (SOCIOGENOME)
Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,
"This project will be the first to engage in a comprehensive study of the role of genes and gene-environment (GxE) interaction on reproductive behaviour. Until now, social science research has focussed on socio-environmental explanations, largely neglecting the role of genes. Due to unprecedented advances in molecular genetics over the last two decades, for the first time in history we are able to ...
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2
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TERMINÉ
Internet Geographies: Changing Connectivities and the Potentials of Sub-Saharan Africa's Knowledge Economy (GeoNet)
Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,
Until recently, access to telecommunication technologies was out of reach for all but the most privileged citizens in Sub-Saharan Africa (SSA). However, recent radical changes that have connected hundreds of millions have encouraged politicians, journalists, academics, and citizens to speak of an IT-fuelled economic revolution happening on the continent. Many see potentials to move away from prima ...
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1
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TERMINÉ
ADVANCED STATISTICAL METHODS FOR HIGH-DIMENSIONAL GENETIC STUDIES (HIGEN)
Date du début: 1 juin 2014, Date de fin: 31 mai 2019,
"Statistical methods play a central role in the field of modern genetics. New technologies are driving an explosion of high-dimensional datasets that will sustain a continuing need for new methods, theory and computationally efficient software. My proposal has two parts that will address the statistical challenges and creation of resources at the frontier of the science in this area. The methods d ...
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1
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TERMINÉ
Cognitive and Biological Factors of Mathematical Learning and Achievement (Learning&Achievement)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,
Mathematical competence is essential for an individual’s functioning in society and for societal prosperity and progress in general. Crucially, the specific cognitive and biological factors that determine high, average, or low mathematical achievement are still poorly understood. The current project aims to address this gap by examining the link between mathematical achievement (cognitive factors) ...
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1
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TERMINÉ
Rich, Structured and Efficient Learning of Big Bayesian Models (BIGBAYES)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,
As datasets grow ever larger in scale, complexity and variety, there is an increasing need for powerful machine learning and statistical techniques that are capable of learning from such data. Bayesian nonparametrics is a promising approach to data analysis that is increasingly popular in machine learning and statistics. Bayesian nonparametric models are highly flexible models with infinite-dimen ...
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1
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TERMINÉ
"Pathogen Phylodynamics: Unifying Evolution, Infection and Immunity" (PATHPHYLODYN)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,
"Genetic sequences represent a rich source of information about evolutionary and ecological processes in natural populations. However the development of methods to recover this information is being outpaced by the explosion in sequence data, especially since the introduction of ‘next-generation’ sequencing. This problem is particularly acute for the inter-disciplinary field of pathogen phylodynami ...
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1
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TERMINÉ
Peptide padlocks evolved towards infinite affinity for antibody nanoassembly and ultrasensitive cell capture (PeptidePadlock)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,
Our ability to tailor individual proteins is now sophisticated, but our ability to assemble such proteins into larger structures is still primitive. Proteins are typically joined by reversible or non-specific linkages. We have designed a unique way to connect protein building blocks irreversibly and precisely, via spontaneous isopeptide bond formation. This involves modifying proteins with a short ...
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1
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TERMINÉ
The plasticity of parental caregiving: characterizing the brain mechanisms underlying normal and disrupted development of parenting (CAREGIVING)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,
"The survival of species depends critically on infant survival and development. Human infants are, however, vulnerable and completely dependent on caregiving parents, not just for survival but also for their development. Darwin and Lorenz have long argued that there are specific infant facial features that elicit attention and responsiveness in adults. Until recently this has not been possible to ...
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1
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TERMINÉ
High Impact Cross-section Calculations for Unprecedented Precision (HICCUP)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,
"The first runs of the Large Hadron Collider (LHC) experiment just finished. The LHC was successful in discovering a particle compatible with the Higgs boson of the Standard Model (SM). However expectations to discover New Physics have not been met so far.In order to establish whether the new resonance is the SM Higgs boson, or not, precise measurements of its properties are mandatory. These requi ...
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2
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TERMINÉ
The 15th-century Book Trade: An Evidence-based Assessment and Visualization of the Distribution, Sale, and Reception of Books in the Renaissance (15CBOOKTRADE)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,
The idea that underpins this project is to use the material evidence from thousands of surviving 15th-c. books, as well as unique documentary evidence — the unpublished ledger of a Venetian bookseller in the 1480s which records the sale of 25,000 printed books with their prices — to address four fundamental questions relating to the introduction of printing in the West which have so far eluded sch ...
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1
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TERMINÉ
Social Change and Everyday Life (SCaEL)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,
I propose a new way of thinking about how the processes of everyday life influence social change.Daily events—driving to work, cinema visits, playing with children—are the atoms of social life. Event sequences aggregate to form societal characteristics (employment levels, rates of cultural participation, amounts of care), and accumulate into biographical characteristics, as a history of continuo ...
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1
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TERMINÉ
Bridging the Evolution and Epidemiology of HIV in Europe (BEEHIVE)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,
The aim of the BEEHIVE project is to generate novel insight into HIV biology, evolution and epidemiology, leveraging next-generation high-throughput sequencing and bioinformatics to produce and analyse whole-genomes of viruses from approximately 3,000 European HIV-1 infected patients. These patients have known dates of infection spread over the last 25 years, good clinical follow up, and a wide ra ...
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1
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TERMINÉ
"Behavioural Economics and Strategic Decision Making: Theory, Empirics, and Experiments" (BESTDECISION)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,
"I will study questions of central microeconomic importance via interwoven theoretical, empirical, and experimental analyses, from a behavioural perspective combining standard methods with assumptions that better reflect evidence on behaviour and psychological insights. The contributions of behavioural economics have been widely recognized, but the benefits of its insights are far from fully reali ...
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1
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TERMINÉ
Memory-enabled Optical Quantum Communications and Information Networks (MOQUACINO)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,
"The primary objective of this proposal is to build a large-scale photonic quantum network in order to enter a new and different regime of macroscopic quantum behaviour for light. We intend to implement a network of sufficient scale that the behaviour of the system is uncomputable, and that new physics will emerge from the study of its dynamics that will inform research in a number of fields deali ...
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1
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TERMINÉ
Nomadic Empires: A World-Historical Perspective (NOMADICEMPIRES)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,
This project provides a wide-ranging and inclusive reinterpretation of the history of equestrian nomadic empires from the fourth century BCE to the late nineteenth century CE. The project has four major objectives that are interrelated. First, it expands the scope of the research significantly by extending it beyond the better known Eurasian nomadic empires into the Americas, where new research ha ...
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1
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TERMINÉ
Changing Structures of Islamic Authority and Consequences for Social Change: A Transnational Review (CSIASC)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
"Research on Muslims in Europe or in the Muslim majority countries has since September 11, mainly focused on understanding the causes of religious radicalization. Largely ignored in the public debates, as well as in academic scholarship, is recognition of the rapid growth in a number of prominent initiatives emerging within Muslims in the west that are aimed at initiating intellectual revival with ...
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1
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TERMINÉ
Genetic and environmental factors that control inflammation-driven colon cancer (INCA)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
"The human gastrointestinal tract is colonized by an abundant and diverse bacterial microbiota that exist in a mutualistic relationship with the host that promotes intestinal health. Maladaptation in this host microbial dialogue leads to a deranged inflammatory response and inflammatory bowel disease (IBD) that can progress to colon cancer. The complex interplay between genetic and environmental f ...
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1
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TERMINÉ
Algorithms and Lower Bounds: A Unified Approach (ALUNIF)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
One of the fundamental goals of theoretical computer science is tounderstand the possibilities and limits of efficient computation. Thisquest has two dimensions. Thetheory of algorithms focuses on finding efficient solutions toproblems, while computational complexity theory aims to understand whenand why problems are hard to solve. These two areas have differentphilosophies and use different sets ...
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2
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TERMINÉ
Mapping the Complexity of Counting (MCC)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
"Just as advances in engineering rely on a deep foundational knowledge of physics, so too advances in algorithms and programming rely on a deep knowledge of the intrinsic nature of computation. Significant progress has been made, particularly in the field of computational complexity, which aims to discover which computational problems are feasible, which are inherently infeasible, and why. However ...
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1
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TERMINÉ
The Diseases of Modern Life: Nineteenth-Century Perspectives (DISEASES)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
"In our current ‘Information Age’ we suffer as never before, it is claimed, from the stresses of an overload of information, and the speed of global networks. The Victorians diagnosed similar problems in the nineteenth century. The medic James Crichton Browne spoke in 1860 of the ‘velocity of thought and action’ now required, and of the stresses imposed on the brain forced to process in a month mo ...
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1
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TERMINÉ
Policing mammalian transcriptomes: regulation of long ncRNA synthesis by transcriptional termination, gene loops and R-loops (polyloop)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
.Mammalian transcriptome analysis reveals that while most of the genome is transcribed, only a minority fraction produces protein coding, messenger RNA or functional, structural RNA. Instead a substantial fraction is transcribed, often tissue specifically, into long non coding (lnc)RNA of mostly unknown function. Many lncRNA are rapidly degraded and may reflect promiscuous, non-functional transcr ...
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1
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TERMINÉ
Unifying Domestication and Evolution through Ancient DNA (UNDEAD)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
"Between 15,000 and 10,000 years ago, human populations in numerous regions of the world forged closer relationships with plants and animals. This domestication process not only significantly altered the genetic, behavioural and phenotypic characteristics of all the species involved, it also laid the foundations for the first urban societies.This project will take advantage of revolutionary geneti ...
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2
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TERMINÉ
Polycomb repressor interactions in relation to the mammalian epigenome (PRIME)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
"In mammals Polycomb group (PcG) repressors play a central role in maintaining cell type specific gene expression patterns in stem cells and through differentiation and development. Accordingly, deficiencies in the Polycomb system are important in disease, notably in several types of cancer. Although it is established that the effector function of PcG proteins is in large part attributable to in ...
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1
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TERMINÉ
Optical Quantum Control of Magnetic Molecules (OptoQMol)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,
A revolution is underway, as molecular magnets are establishing a fundamental link between spintronics, molecular electronics and quantum computation. On the other hand, we know almost nothing on how a magnetic molecule is affected by electrons flowing through it or by the excitation of a molecular group. OptoQMol will investigate these uncharted waters by developing innovative, ultra-clean method ...
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2
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TERMINÉ
Robust Financial Mathematics: model-ambiguous framework for valuation and risk management (ROBUSTFINMATH)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,
"The last forty years have seen a remarkable interplay between Mathematics and contemporary Finance. At the heart of the successful growth of Mathematical Finance was a perfect fit between its dominant model--specific framework and the tools of stochastic analysis. However, this approach has always had important limitations, and the dangers of overreach have been illustrated by the dramatic events ...
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1
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TERMINÉ
"The Cult of Saints: a christendom-wide study of its origins, spread and development" (COS)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,
"An investigation of the origins and development of a central feature of late-antique, medieval and modern culture: the belief that dead saints can act as mediators between a distant God and humankind, and that they are active on earth in many different ways (such as healing the sick, punishing the irreverent, or even controlling the weather).The project will investigate the emergence of this beli ...
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3
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TERMINÉ
Optical imaging of nanoscopic dynamics and potentials (NanoScope)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,
I propose to develop and apply a novel approach to optical microscopy to enable the direct visualization and study of dynamics on the nanoscale in biological and condensed matter physics. Given the speed with which nanoscopic objects move at ambient condition, this requires simultaneously very fast (ms) and precise (nm) imaging. The challenge is to avoid excessive perturbation of the system and e ...
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1
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TERMINÉ
Towards Total Scene Understanding using Structured Models (HELIOS)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,
"This project is at the interface between computer vision and linguistics: the aim is to have an algorithm generate relevant sentences that describe a scene given one or more images.Scene understanding has been one of the central goals in computer vision for many decades. It involves various individual tasks, such as object recognition, action understanding and 3D scene recovery. One simple defini ...
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1
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TERMINÉ
"DRAGNET: A high-speed, wide-angle camera for catching extreme astrophysical events" (DRAGNET)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,
"Looking up on a starry night, it’s easy to imagine that the Universe is unchanging. In reality, however, the Universe is teeming with activity: there are massive explosions from accreting black holes, bright radio flashes from ultra-magnetic pulsars, and likely other spectacles that have so far escaped our prying eyes. These fleeting events can happen faster than the blink of an eye and, importan ...
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2
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TERMINÉ
Magnetic sensing by molecules, birds, and devices (ChemNav)
Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,
The sensory mechanisms that allow birds to perceive the direction of the Earth’s magnetic field for the purpose of navigation are only now beginning to be understood. One of the two leading hypotheses is founded on magnetically sensitive photochemical reactions in the retina. It is thought that transient photo-induced radical pairs in cryptochrome, a blue-light photoreceptor protein, act as the pr ...
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2
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TERMINÉ
Complex Synthetic Mimics of the Cell Membrane (COSMIC)
Date du début: 1 févr. 2013, Date de fin: 31 oct. 2018,
I propose to bridge the gap between simple in vitro measurements of biological processes, and the complexities of the cellular environment. This requires reduced in vitro systems that are sufficiently complex to reproduce the subtleties of the in vivo biological phenomenon, but sufficiently controllable to test how quantitative changes in a particular property affects function. The challenge is to ...
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2
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TERMINÉ
Impacts and risks from higher-end scenarios: Strategies for innovative solutions (IMPRESSIONS)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,
IMPRESSIONS will provide empirically-grounded, transformative science that quantifies and explains the consequences of high-end climate scenarios for both decision-makers and society. IMPRESSIONS will develop and apply a novel participatory methodology that explicitly deals with uncertainties and strong non-linear changes focussing on high-end climate change, but also including intermediate warmin ...
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