13 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Regulatory transcriptional networks orchestrating mouse pluripotent embryonic stem cells (SysStemCell)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
The lack of a quantitative framework around the dynamics of gene expression and its determinants represents a major hurdle for capturing transcription regulation into regulatory models. Embryonic Stem Cells (ESC) provide an excellent cellular model to quantitatively define the principles of gene regulation at the biochemical and (epi)genetic level. In SysStemCell, I will focus on two distinct mous ...
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1
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TERMINÉ
Regulation of gene expression and cell fate by DNA (hydroxy)methylation (HeavyMethyl)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
(Hydroxy)methylation of cytosine residues in eukaryotic DNA represents a major means to regulate gene expression during development. These modifications are considered to be epigenetic marks, since they have a profound impact on phenotype, but are inherited from mother to daughter cells independent of the underlying DNA sequence. Large efforts are currently underway to profile genome-wide DNA (hyd ...
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2
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TERMINÉ
"Quantum Computation, Logic, and Security" (QCLS)
Date du début: 1 mai 2013, Date de fin: 30 avr. 2018,
"Quantum computing involves a new computational paradigm based on thelaws of quantum mechanics. It uses qubits, which are superpositions ofordinary bits, and exploits the `strange' quantum phenomena likeentanglement of qubits. It promises new forms of very fast,distributed computation. First applications are now appearing incomputer security, based on the manipulation of individual qubits. Therea ...
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1
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TERMINÉ
Genetic interaction networks in a self-renewing human tissue (TissueControlNetwork)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
Both epigenetic factors and microRNAs have the potential to control transcript levels of large sets of genes through transcriptional and post-transcriptional mechanisms. Faithful stem cell function is crucial for tissue maintenance and repair throughout life and requires these machineries to establish specific and dynamic transcription programs. However, how miRNAs and chromatin-factors cooperate ...
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1
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TERMINÉ
Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation, in health and disease (4DCELLFATE)
Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,
Embryonic stem (ES) cells have the potential to differentiate into any type of cell as well as to renew indefinitely in culture. They hold great potential for the development of personalized medicines. However, the molecular mechanisms underpinning cell fate decisions by individual cells are poorly understood. There is compelling evidence that two large multi-protein machines, the Nucleosome Remod ...
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13
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TERMINÉ
User Empowerment for Enhanced Online Presence Management (USEMP)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,
A large majority of Europeans engage with Online Social Networks (OSNs) and a recent Eurobarometer study concludes that 74% of respondents think that they do not have enough control of the data they share and 70% are concerned with the way such data are handled by OSNs. In response to these concerns, USEMP aims at developing a framework that will empower users by enhancing their control over the d ...
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7
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TERMINÉ
A systematic analysis of parasite metabolism - from metabolism to intervention (ParaMet)
Date du début: 1 juin 2012, Date de fin: 31 mai 2016,
Parasites exact a devastating toll on health and economic productivity, infecting man and also domestic livestock. Drugs used to combat parasitic diseases are deficient in many ways and new, better drugs are needed to establish sustainable means to combat diseases caused by protozoan parasites that include malaria, trypanosomiasis and leishmaniasis in man, and coccidiosis among others in animals. ...
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12
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TERMINÉ
Epigenetics towards systems biology (EPIGENESYS)
Date du début: 1 oct. 2010, Date de fin: 31 mars 2016,
The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is nee ...
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28
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TERMINÉ
C-DAX: Cyber-secure Data and Control Cloud for Power Grids (C-DAX)
Date du début: 1 oct. 2012, Date de fin: 29 févr. 2016,
The progressive penetration of conventional and renewable distributed generation is driving major changes in the whole power systems infrastructure justifying the introduction of more intelligence, in particular, in power distribution networks. The information infrastructure will play a central role as future power systems cannotbe supported by centralized information infrastructures on which toda ...
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10
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TERMINÉ
Systems Biology of Colorectal Cancer (SYSCOL)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,
Colorectal cancer (CRC) is one of the most common cancers in both males and females, and it is perhaps the best understood of all epithelial tumors in terms of its molecular origin. Yet, despite large amount of work that has concentrated on understanding of colon tumorigenesis, we still do not know the full complement of molecular lesions that are individually necessary – and together sufficient – ...
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11
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TERMINÉ
Shaping the future of electronic identity (FutureID)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2015,
The FutureID project builds a comprehensive, flexible, privacy-aware and ubiquitously usable identity management infrastructure for Europe, which integrates existing eID technology and trust infrastructures, emerging federated identity management services and modern credential technologies to provide a user-centric system for the trustworthy and accountable management of identity claims.The Future ...
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20
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TERMINÉ
Quantum Gravity and the Early Universe (Quantum Cosmology)
Date du début: 16 nov. 2012, Date de fin: 21 avr. 2015,
Quantum Gravity will be studied in the context of early universe cosmology. Specifically, inhomogeneous perturbations, and their evolution, within Loop Quantum Cosmology will be developed so as to allow direct observational testing of the theory. A phase of the early universe that is dominated by Quantum Gravity may produce effects observable in the detailed structure of the Cosmic Microwave Back ...
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1
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TERMINÉ
From Black Holes to Ultra-High Energy Cosmic Rays: Exploring the Extremes of the Universe with Low-Frequency Radio Interferometry (LOFAR-AUGER)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2013,
"Black holes (BHs) and ultra-high energy cosmic rays (UHECRs) are two extremes of the universe that link particle physics and astrophysics. BHs are the most efficient power generators in the universe while UHECRs are the most energetic particles ever detected. As we showed previously, a major fraction of the power of BHs is channeled into radio-emitting plasma jets, which are also efficient partic ...
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