4 projets européens trouvés
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TERMINÉ
Modeling Disease through Cell Reprogramming: a Translational Approach to the Pathogenesis of Syndromes Caused by Symmetrical Gene Dosage Imbalances (DISEASEAVATARS)
Date du début: 1 sept. 2014, Date de fin: 31 août 2019,
The fundamental limitation in our ability to dissect human diseases is the scarce availability of human tissues at relevant disease stages, which is particularly salient for neural disorders. Somatic cell reprogramming is overcoming this limitation through the derivation of patient-specific induced pluripotent stem cells (iPSC) that can be differentiated into disease-relevant cell-types. Despite t ...
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3
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TERMINÉ
Immune mechanisms that control the homeostasis of the gut and that are deregulated in intestinal pathologies cancer (HOMEOGUT)
Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,
This project stems from an ERC STG grant that I received in 2007 (DENDROworld) in which we analyzed several aspects of the homeostasis of the gut and how defects in controlling this process could result in different pathologies, including inflammatory bowel disease (IBD) and cancer. In the present project, we will continue working on the immune homeostasis of the gut and we will focus on fundament ...
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3
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TERMINÉ
Long non-coding RNAs of tumor infiltrating lymphocytes as novel anti-cancer therapeutic targets (FIGHT-CANCER)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,
Although tumor tissues can be infiltrated by T cells specific for tumor antigens, the effector functions of these lymphocytes are generally suppressed by CD4+ regulatory T cells (Tregs). Since tumor infiltrating Tregs can display function heterogeneity, depending on both the tumor type and the inflammatory milieu, only inhibition of the right Treg activity should result in the unleash of an effect ...
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2
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TERMINÉ
Lymphocyte microRNAs in health and disease: Understanding lymphocyte functions through the identification of microRNA target genes and exploiting serum microRNA signatures to monitor immune responses (I-MIRNOME)
Date du début: 1 juin 2011, Date de fin: 31 mai 2016,
Background: CD4+ T lymphocyte subsets orchestrate immune responses in health and disease. Little is known on control of T cell differentiation exerted by microRNA that affect mRNA translation. The identification of microRNA and their targets that regulate differentiation of T cell subsets may provide new therapeutic targets for immune-mediated diseases. Since microRNA are released in exosomes and ...
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