10 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
BeTheCuRE (BTCURE)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2017,
BTCure is based on the recognition that RA is a heterogeneous disease where a major subset involves adaptive immunity, and that animal models have to develop the line with the different subsets of the human diseases in order to be optimally used for drug discovery and drug evaluation. Our aim is to develop an understanding of the early process in human arthritis subsets and the animal models that ...
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41
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TERMINÉ
Scaffolds for alternative delivery (SADEL)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,
The SME-based SADEL consortium intends to develop the first generation of oral bio-therapeutics tackling disease targets in the digestive tract, by making optimal use of the Nanofitin (Nf) protein scaffold. Nf based drugs will progress through routes not travelled by antibodies while interacting with targets not modulated by chemical compounds.Existing Nf hits against validated targets will progre ...
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10
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TERMINÉ
Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation (INFRAFRONTIER-I3)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,
The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:• Develop a series of mutant alleles for every gene in the mouse genome• Determine the phenotypic consequences of each mutation• Identify mouse models for the complete dise ...
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24
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TERMINÉ
Mechanisms to Attack Steering Effectors of Rheumatoid Syndromes with Innovated Therapy Choices (Masterswitch)
Date du début: 1 déc. 2008, Date de fin: 30 nov. 2013,
Objective: To delineate the biological and molecular pathways that initiate and drive chronic inflammatory disease and to transform the knowledge obtained into the development of novel anti-inflammatory interventions. Focus will be given to Rheumatoid Arthritis (RA) since longitudinal data indicate that intensive treatment can prevent persistency and chronicity. State of the Art and beyond: The ...
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20
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TERMINÉ
Chromatin diseases: from basic mechanisms to therapy (DisChrom)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,
The scope of this ITN is to promote research and training in the field of chromatin diseases. Chromatin diseases (CD) are genetic pathologies resulting from mutations in structural components of chromatin or in enzymes that biochemically modify chromatin, altering chromatin status and thereby causing drastic effects on gene expression. CD frequency ranges from very rare to quite common pathologies ...
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11
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TERMINÉ
“The International Data Coordination Centre” (I-DCC)
Date du début: 1 janv. 2009, Date de fin: 30 sept. 2013,
"The I-DCC coordination and support project responds to the topic defined by HEALTH-2007-2.1.2-6 “International activities in large-scale data gathering and systems biology”. I-DCC integrates European skills, efforts, resources, and infrastructure in an international collaborative programme to establish a European Data Coordination Centre for mouse genetic resources. Large-scale mouse mutagenesis ...
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10
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TERMINÉ
Biology of Liver and Pancreatic Development and Disease (BOLD)
Date du début: 1 sept. 2009, Date de fin: 31 août 2013,
Aims: provide a cutting edge research training programme encompassing complementary approaches to the investigation of liver and pancreatic development and disease. Provide early stage researchers with a balanced mix of experience and skills in academic and industry based research. Give early stage researchers a set of transferrable skills which will improve their employment and career prospects. ...
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12
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TERMINÉ
Development of sensitive methodologies for exploitation of early epigenetic marker diagnosis in major types of cancer (EpiDiaCan)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2012,
Cancer is one of the major causes of mortality. Epithelial cells become malignant after accumulating genetic mutations followed by morphological changes in the epithelium. DNA Alterations include stable genetic changes in oncogenes, tumor suppressor genes and reversible epigenetic changes. Different forms of epigenetic mechanisms have been shown to modify the expression of key genes during tumour ...
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7
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TERMINÉ
Enhancing BSRC Al. Fleming research potential in genomics and proteomics applications (GENPRO)
Date du début: 1 déc. 2009, Date de fin: 30 nov. 2012,
"BSRC Al. Fleming is the most rapidly developing research center in Greece. It started its operation under an interim administrative board in 1998 and develops research programs at the cutting edge of modern biomedical sciences. The aim of this project is to reinforce and enhance the scientific research potential of the BSRC Al. Fleming in the areas of functional genomics and proteomics. This aim ...
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1
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TERMINÉ
Coordination of resources for conditional expression of mutated mouse alleles (CREATE)
Date du début: 1 nov. 2008, Date de fin: 31 oct. 2011,
"This proposal describes CREATE, an internationally based Coordination Action directly addressing a large scale data gathering activity for systematic conditional mouse mutagenesis. Advances in the sophisticated manipulation of the mouse genome has established the mouse as the premier organism for developing models of human disease. Internationally coordinated initiatives have established for the ...
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