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12 projets européens trouvés

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 TERMINÉ 

Novel insights into cardiac regeneration through studies in the zebrafish (zebraHeart)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Myocardial infarction (MI) leads to cardiomyocyte death and accumulation of myofibroblasts (MFs) at the site of injury, which produce large amounts of extracellular matrix (ECM), generating a scar. Initially, cardiac fibrosis protects from ventricular wall rupture, but subsequent myocardial remodelling causes heart failure, representing a leading cause of death in Europe. While MFs play a central ...
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 2

 TERMINÉ 

CNIC International Postdoctoral Programme (CNIC IPP)

Date du début: 3 juin 2013, Date de fin: 2 juin 2018,

"The proposed CNIC International Postdoctoral Programme (CNIC IPP) is aimed at supporting trans-national mobility of postdoctoral researchers and to broaden and deepen their individual competence, particularly in terms of acquisition of complementary skills needed to become an independent group leader in the future.The programme offers fellowships for researchers who hold a PhD Degree at the time ...
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 1

 TERMINÉ 

COMBINATIONAL USE OF INNATE IMMUNE RECEPTORS FOR CANCER IMMUNOTHERAPY (PRR IN IMMUNOTHERAPY)

Date du début: 1 juin 2013, Date de fin: 31 mai 2017,

Cancer is a major scientific and economical challenge that our society has to face and new therapeutic approaches should now be evaluated in order to decrease human and financial cost of this disease. After suffering from many drawbacks, cancer immunotherapy, which aims at mobilizing the immune system to fight cancer, has recently gained enthusiasm with the completion of several randomized phase I ...
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 1

 TERMINÉ 

Mechanisms of MTOC guidance and Genetic Transfer at the Immune Synapse: novel modes of Immuno-modulation (GENTRIS)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,

"Cell-cell synapses are an exquisitely evolved means of communication between cells. During the formation of the immune synapse (IS), diverse transmembrane and membrane associated molecules are reorganized into a highly segregated structure at the T cell–Antigen-Presenting Cell (APC) contact site. As part of this process, the tubulin cytoskeleton is vectorially directed toward the center of the IS ...
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 2

 TERMINÉ 

Clot formation as a potential diagnostic tool and therapeutic target for Alzheimer's disease (ADvasculature)

Date du début: 15 janv. 2015, Date de fin: 14 janv. 2017,

Alzheimer’s disease (AD) is the leading cause of dementia in the elderly. Accumulating evidence links AD with vascular risk factors. These correlations, together with profound alterations of cerebrovascular structure and function present in AD, suggest a “vascular hypothesis”, where vascular pathology eventually leads to neurodegeneration and subsequent cognitive decline. A decrease in cerebral bl ...
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 1

 TERMINÉ 

Mitochondrial European Educational Training (MEET)

Date du début: 14 janv. 2013, Date de fin: 13 janv. 2017,

"The expanding diversification and specialization of knowledge and the growing complexity of contemporary research in translational research warrant the creation of cooperative multi-disciplinary networks including both basic and medically oriented expertise. This notion is especially true for Mitochondrial Medicine which aims at understanding the physiopathological mechanisms sharing the features ...
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 10

 TERMINÉ 

Homeostatic regulation of mesenchymal stem cells in the haematopoietic stem-cell niche (MSC-HSC NICHE)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

The cells forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear. Our recent studies have demonstrated that mesenchymal stem cells (MSC) identified using expression of the intermediate filament protein nestin constitute an essential HSC niche component. Nestin+ cells contribute to bone formation, contain all the mesenchymal activity and can self-renew and expand in serial ...
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 1

 TERMINÉ 

Living Photonics: Monitoring light propagation through cells (LiPhos)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2015,

LIPHOS is focused on the development of completely innovative biophotonic diagnosis tools, which are for the first time implemented using cells as constituent material. Here, and unlike existing systems, light remains confined in a waveguide whose core is uniquely composed by cells, giving rise to the "Living photonics" concept. In this context, cells play a two-fold role: i) they form the biomate ...
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 8

 TERMINÉ 

CNIC INTERNATIONAL INCOMING FELLOWSHIPS FOR YOUNG GROUP LEADERS (CNIC IIF)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,

The CNIC IIF Programme will offer a total of 24 positions during the COFUND programme life (four years) in the incoming mobility type in the area of cardiovascular research.Every year six fellowships will be offered at the level of young group leaders: 4 Starting Fellowships (SF) and 2 Advanced Fellowships (AF). In both cases, the duration of the fellowships will be 3 years and have particular ob ...
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 1

 TERMINÉ 

Oxygen sensing in cardiovascular progenitors cell fate decisions (Hypoxia & Cell Fate)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

Cardiogenesis is a complex process that involves different cell types that have to mature to form the final functional heart compartments. Isl1 cardiovascular progenitors label the “second heart field” and contribute to myocardial, smooth muscle and endothelial structures of the heart. These progenitors have been extensively studied but little is know about the extracellular signals mediating thei ...
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 1

 TERMINÉ 

Molecular mechanisms of mature B cell lymphomagenesis (BCLYM)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2014,

Most of the lymphomas diagnosed in the western world are originated from mature B cells. The hallmark of these malignancies is the presence of recurrent chromosome translocations that usually involve the immunoglobulin loci and a proto-oncogene. As a result of the translocation event the proto-oncogene becomes deregulated under the influence of immunoglobulin cis sequences thus playing an importan ...
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 2

 TERMINÉ 

Role of PPARgamma in the interstitial fluid volume regulation and contribution to cardiovascular complications of TZDs (PGFC)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2011,

"Thiazolidinediones (TZDs) are clinically proven insulin sensitizers with anti-inflammatory benefits used in the therapy of type 2 diabetes mellitus (T2DM) and atherosclerosis. TZDs can activate a transcription factor, the peroxisome proliferator-activated receptor gamma (PPARg). PPARg regulates expression of several genes involved in inflammatory pathways, lipid transport and carbohydrate metabol ...
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 1