3 projets européens trouvés
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TERMINÉ
Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation (INFRAFRONTIER-I3)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,
The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:• Develop a series of mutant alleles for every gene in the mouse genome• Determine the phenotypic consequences of each mutation• Identify mouse models for the complete dise ...
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24
Participants partenaires
TERMINÉ
To decipher the optimal management of systemic sclerosis (DESSCIPHER)
Date du début: 1 déc. 2012, Date de fin: 30 nov. 2015,
The current approach to diagnosis and management of the rare disease systemic sclerosis (SSc) is based on American College of Rheumatology criteria with low sensitivity and few validated recommendations for the therapy of the disease and its manifold organ manifestations. To overcome these shortcomings, the DeSScipher project will use the multinational, prospective and open EUSTAR (Scleroderma Tri ...
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15
Participants partenaires
TERMINÉ
Large-scale, high-throughput automated systems for phenotyping mouse models of human disease (PhenoScale)
Date du début: 1 mars 2009, Date de fin: 29 févr. 2012,
We are now entering an era of genomic exploration. The mouse is a pre-eminent model not only to map all mammalian genes, but to determine the function of each of these genes. There are now many large-scale projects to create collections of mutant and knock-out mice. However the next step which will add immense value to these collections will be the determination of the phenotype of each of these m ...
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