7 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Biogenesis of lipid droplets and lipid homeostasis (DROPFAT)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,
Organisms and cells face a myriad of environmental changes with periods of nutrient surplus and shortage. It is therefore not surprising that in all kingdoms of life, cells have evolved the means to store energy and thereby minimize the effects of environmental fluctuations. While the capability for energy storage has obvious advantages, deregulated energy accumulation can also be detrimental and ...
Voir le projet
2
Participants partenaires
TERMINÉ
Identification of the mechanisms of unconventional protein secretion: AP2, a new protein secreted by this unknown pathway (UnProSec)
Date du début: 15 mai 2014, Date de fin: 14 mai 2017,
Most of the secreted proteins transit into and through the endoplasmic reticulum (ER) and the Golgi apparatus. However, eukaryotic cells secrete a class of proteins, which do not enter the ER. Very little is known about this “unconventional secretory pathway”. The last protein identified to be secreted by this pathway is AP2, a cytoplasmic fatty acid-binding protein, which is secreted unconvention ...
Voir le projet
1
Participant partenaire
TERMINÉ
Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation (INFRAFRONTIER-I3)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,
The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:• Develop a series of mutant alleles for every gene in the mouse genome• Determine the phenotypic consequences of each mutation• Identify mouse models for the complete dise ...
Voir le projet
24
Participants partenaires
TERMINÉ
Reconstitution of CUPS in vitro and assessing the mechanism of their cargo packing during unconventional protein secretion (CUPS)
Date du début: 1 mars 2014, Date de fin: 29 févr. 2016,
Most proteins secreted by eukaryotic cells use the endoplasmic reticulum (ER)-to-Golgi pathway of secretion. This is dependent on signal-peptide sequences that ensure protein translocation into the ER and their progress to the cell surface through vesicular flow via the Golgi apparatus. However, a substantial number of proteins that lack a signal-peptide sequence are secreted without entering the ...
Voir le projet
1
Participant partenaire
TERMINÉ
Marine Microbial Biodiversity, Bioinformatics and Biotechnology (MICRO B3)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
Micro B3 will develop innovative bioinformatic approaches and a legal framework to make large-scale data on marine viral, bacteria; archaeal and protists genomes and metagenomes accessible for marine ecosystems biology and to define new targets for biotechnological applications. Micro B3 will build upon a highly interdisciplinary consortium of 32 academic and industrial partners comprising world-l ...
Voir le projet
32
Participants partenaires
TERMINÉ
Broadening the Bioinformatics Infrastructure to unicellular, animal, and plant science (ALLBIO)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2014,
The main aim of AllBio will be the coordination of the partner's activities that are aimed at the extension of a large number of bioinformatics facilities towards applicability in target life science areas beyond human health. Bioinformatics facilities developed for the human health area will be extensively tested on unicellular (incl. bacterial), plant and (farm) animal genomes, and they will be ...
Voir le projet
11
Participants partenaires
TERMINÉ
Data Infrastructure for Chemical Safety (diXa)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2014,
The EU nowadays witnesses increasing demands with regard to chemical safety. In particular, animal-based test models need to be replaced preferably by robust, non-animal assays in vitro/in silico which better predict human toxicity in vivo, are less costly, and are socially better acceptable. Consumer's and patient's health will benefit and competitiveness of EU's chemical manufacturing industry w ...
Voir le projet