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18 projets européens trouvés

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 TERMINÉ 

Engineering Discoidal Polymeric Nanoconstructs for the Multi-Physics Treatment of Brain Tumors (POTENT)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,

"Despite significant advances in chemotherapy, the effective treatment of malignant masses via systemically injectable agents are still limited by insufficient accumulation at the biological target (
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 1

 TERMINÉ 

A common European approach to the regulatory testing of nanomaterials (NANOREG)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

The innovative and economic potential of Manufactured Nano Materials (MNMs) is threatened by a limited understanding of the related EHS issues. While toxicity data is continuously becoming available, the relevance to regulators is often unclear or unproven. The shrinking time to market of new MNM drives the need for urgent action by regulators. NANoREG is the first FP7 project to deliver the answe ...
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 73

 TERMINÉ 

Emulating the C. elegans nervous system: A blueprint for brain-inspired computational architectures (Si elegans)

Date du début: 1 avr. 2013, Date de fin: 30 sept. 2016,

Biological neural systems are powerful, robust and highly adaptive computational entities that outperform conventional computers in almost all aspects of sensory-motor integration. Despite dramatic progress in information technology, there is a big performance discrepancy between artificial systems and brains in seemingly simple orientation and navigation tasks. In fact, no system exists that can ...
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 5

 TERMINÉ 

Astrocyte regulation of circadian behavior (ASTROCLOCK)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2016,

The human brain contains more than 100 billion cells, the majority being non-excitable glial cells, remarkably coordinated by an intrinsic clock that produce a circadian rhythm in their physiology and behavior. Circadian alterations affect human performances, productivity and are associated to increased risk of human-error related accidents and to a variety of brain disorders (e.g. sleep disorders ...
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 1

 TERMINÉ 

Bioplastic production from tomato peel residues (BIOPROTO)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2016,

This proposal aims to develop an integral re-exploitation of the tomato fruit peels from processing tomato industries. In particular, the project is focus on the bio-mimicry of the plant cuticle, in order to obtain bioplastics with commercial purposes. Tomato fruits were chosen for, first, their high proportion of cuticular components, second, the inexpensive price of their peel, and, third, the h ...
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 1

 TERMINÉ 

NEUROGENESIS IN 22Q11.2 DELETION SYNDROME: ROLE OF microRNAs (miRNAs/22q11DS)

Date du début: 1 juin 2011, Date de fin: 31 mai 2015,

The 22q11.2 deletion syndrome (22qDS) is the most common hemizygous microdeletion syndrome occurring in humans. Individuals with 22qDS show also a variety of neuro−anatomical defects.Our central hypothesis is that altered miRNAs biogenesis (caused by the hemizygous deletion of Dgcr8, one of the genes located in the 22q11.2 critical region, and required for miRNAs maturation) might impair embryonal ...
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 1

 TERMINÉ 

Linking biological and artificial neuronal assemblies to restore lost brain functions: towards the design of innovative bi-directional neuroprostheses (BRAINBOW)

Date du début: 1 févr. 2012, Date de fin: 31 mai 2015,

The possibility to control actions from thoughts is becoming reality thanks to Brain Machine Interfaces (BMIs). However modern BMIs are mostly unidirectional and aimed at restoring lost motor functions. In a wider perspective, neural interfaces must be bi-directional devices that substitute motor, sensory or cognitive circuits within the brain, that might have been damaged as a result of an injury ...
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 7

 TERMINÉ 

Innovative Robotic Artefacts Inspired by Plant Roots for Soil Monitoring (PLANTOID)

Date du début: 1 mai 2012, Date de fin: 30 avr. 2015,

We aim at designing, prototyping, and validating a new generation of ICT hardware and software technologies inspired from plant roots, called PLANTOIDS, endowed with distributed sensing, actuation, and intelligence for tasks of environmental exploration and monitoring. PLANTOIDS take inspiration from, and aim at reproducing, the amazing penetration, exploration, and adaptation capabilities of plan ...
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 4

 TERMINÉ 

Role of genetic interaction between COMT and Dysbindin in cognitive and schizophrenia-related abnormalities (SCHIZOGENES)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2014,

"Cognitive deficits are common in most brain disorders and are characteristic of schizophrenia, which is among the most debilitating and costly diseases. Genetic association studies have implicated several potential schizophrenia-susceptibility genes, but a direct genetic cause/mechanism remains elusive. Schizophrenia is dependent upon dysregulation of the dopaminergic system, particularly in the ...
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 1

 TERMINÉ 

POLYGLUTAMINE DISEASES: IMPACT OF PROTEIN AND CELL CONTEXT ON NEUROTOXICITY (PolyQ/AR)

Date du début: 1 juin 2010, Date de fin: 31 mai 2014,

Spinal and bulbar muscular atrophy (SBMA) is one of nine polyglutamine diseases and is caused by expansion of CAG in the androgen receptor (AR) gene. Despite the widespread distribution of polyglutamine proteins in the central nervous system, specific populations of neurons are vulnerable in each disease, suggesting that selective neuronal vulnerability arises from intrinsic properties of the muta ...
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 1

 TERMINÉ 

Assembly of Colloidal Nanocrystals into Unconventional Types of Nanocomposite Architectures with Advanced Properties (NANO-ARCH)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,

"Nanoscience promises innovative solutions in a large variety of sectors, ranging from cost-effective optoelectronic devices to energy generation, and to highly performing materials and interfaces. Realizing this promise will rely heavily on a bottom-up approach. This can only succeed if self assembly of advanced nanoscale building blocks will be developed intensively, to enable creation of useful ...
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 1

 TERMINÉ 

Development of a high sensitive and specific nanobiosensor based on surface enhanced vibrational spectroscopy dedicated to the in vitro proteins detection and disease diagnosis (Nanoantenna)

Date du début: 1 oct. 2009, Date de fin: 31 mars 2013,

The main goal of our proposal is to develop a novel optical nanobiosensor based on extraordinary vibrational signal enhancement of the proteins to be detected. To reach vibrational signal enhancement, we will exploit the optical properties of specially designed metallic nanoparticles which should act as nanoantenna and the associated field enhancement to obtain a direct detection of proteins bound ...
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 13

 TERMINÉ 

MAGNETIC NANOCONTAINERS FOR COMBINED HYPERTHERMIA AND CONTROLLED DRUG RELEASE (MAGNIFYCO)

Date du début: 1 sept. 2009, Date de fin: 28 févr. 2013,

The aim of this project is the assembly and the fabrication of a new generation of multifunctional nanostructures for performing combined hyperthermia and controlled drug release, specifically targeted to cancer cells. The “magnetic nanocontainers” we intend to develop can perform at the same time cell recognition, hyperthermia treatment, and, as a consequence of the heat and /or cell environment ...
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 11

 TERMINÉ 

Single or few molecules detection by combined enhanced spectroscopies (SMD)

Date du début: 1 juil. 2009, Date de fin: 30 juin 2012,

Future breakthroughs in the understanding of fundamental biological processes causing major diseases are expected from the development of miniaturized probes or microscopes able to detect and identify a single or a small number of molecules. The SingleMoleculeDetection (SMD) proposal will develop a unique device able to perform simultaneously and in a dynamic way force and spectroscopic measuremen ...
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 8

 TERMINÉ 

Large-scale, high-throughput automated systems for phenotyping mouse models of human disease (PhenoScale)

Date du début: 1 mars 2009, Date de fin: 29 févr. 2012,

We are now entering an era of genomic exploration. The mouse is a pre-eminent model not only to map all mammalian genes, but to determine the function of each of these genes. There are now many large-scale projects to create collections of mutant and knock-out mice. However the next step which will add immense value to these collections will be the determination of the phenotype of each of these m ...
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 5

 TERMINÉ 

Macroscopic Interference Devices for Atomic and Solid-State Systems: Quantum Control of Supercurrents (MIDAS)

Date du début: 1 avr. 2008, Date de fin: 30 sept. 2011,

The quantum technologies that are coming to fruition are narrow, isolated niches separated by vast domains of technologies still ruled by classical physics. The formidable challenge of creating a broad quantum-technological base calls for bridging and integrating these niches. In this spirit, we wish to capitalize on the remarkable analogies that have recently emerged between two previously unrela ...
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 13

 TERMINÉ 

Coordination action for enhancing the breakthrough of intelligent textile systems (e-textiles and wearable Microsystems) (SYSTEX)

Date du début: 1 mai 2008, Date de fin: 31 juil. 2011,

Wearable electronics embedded in or transformed into textile systems are a new generation of products that contribute to economy as well as to society. SYSTEX wants to bring partners involved in European projects in this area together in order to group the results of numerous efforts that are currently going on. It wants to expand the platform to national level and to merge textiles and organic e ...
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 12

 TERMINÉ 

RESEARCHERS ON THE ROCK (ROCK'N...)

Date du début: 1 mai 2010, Date de fin: 30 nov. 2010,

"ROCK’N…aims to favour a direct contact between researchers and the large public in way that people could understand and give the right value to the great contribution they give to our daily life. At the same time, the project intends to offer researchers opportunities to meet the public at large in informal situations, not only sharing with it experiences, emotions, difficulties, but also involvi ...
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 8