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15 projets européens trouvés

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 TERMINÉ 

Nanomedicine Doctoral Programme (NanoMedPhD)

Date du début: 15 sept. 2016, Date de fin: 14 sept. 2021,

Biomedical research is one of the most important factors of economic development in modern societies, and a strategic element of major importance for the economic growth of the European Union. In particular, according to the White Paper to the Horizon 2020 Framework Programme for Research and Innovation of the Nanomedicine European Technology Platform, nanomedicine underspins a strong research and ...
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 1

 TERMINÉ 

Exploring the combined role of genetic and non-genetic factors for developing Age-Related Macular Degeneration: A systems level analysis of disease subgroups, risk factors, and pathways (EYE-RISK)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

Age-related macular degeneration (AMD) is the world’s most important age-related blinding disorder. The current proposal utilises epidemiological data describing clinical phenotype, molecular genetics, lifestyle, nutrition, and in-depth retinal imaging derived from existing longitudinal European epidemiological cohorts and biobanks to provide three major insights needed for long-lasting prevention ...
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 13

 TERMINÉ 

Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases (PRECISESADS)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

We concur to the IMI on “Reclassification of SLE, connective tissue diseases and RA” call by presenting a proposal aimed at using the power of OMICs, and bioinformatics to identify new classifications for diseases known to share common pathophysiological mechanisms. Such knowledge has not been applied to individual patients, depriving them from potential benefits in terms of the use of new therape ...
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 30

 TERMINÉ 

Epigenetic control and impact of mammalian retrotransposons in pluripotent genomes (EPIPLURIRETRO)

Date du début: 1 juil. 2013, Date de fin: 30 juin 2018,

Almost half of the human genome is made of Transposable Elements (TEs), whose ongoing activity continually impacts our genome. However, little is known about how the host regulates TEs and their genomic and epigenomic impacts. EpiPluriRetro will advance research in a new groundbreaking concept: that TEs are active in our pluripotent genome, and that epigenetic regulation is employed therein to reg ...
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 1

 TERMINÉ 

Mobile elements: shuffling the regulome in development and disease (EVOLINE)

Date du début: 2 févr. 2015, Date de fin: 1 févr. 2018,

The present structure of the human genome is largely a result of the activity of Transposable Elements (TEs) or jumping genes. Indeed, they have constantly provided genomic variability over evolution, resulting in the generation of new genes and new regulatory circuits among others, and they are still doing it now, mainly leaded by the activity of few classes of TEs as LINE-1 retrotransposons.LINE ...
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 1

 TERMINÉ 

Open Researchers (OPENRESEARCHERS)

Date du début: 1 avr. 2016, Date de fin: 30 nov. 2017,

‘Open Researchers’ is the fifth experience of Andalusia in the European Researchers’ Night. The project is designed to increase the awareness of research as a solution to the numerous challenges faced by citizens all around the world and mainly in Europe. The idea of the project, ‘The future is today: understandable ground-breaking science for a better living’, has been conceived in a time of chan ...
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 13

 TERMINÉ 

Generation of human experimental models of Bernard-Soulier Syndrome and Glanzmann Disease using cellular reprogramming (PLATELET DISORDERS)

Date du début: 14 janv. 2015, Date de fin: 13 janv. 2017,

Glanzmann's Disease, also known as Glanzmann's thrombasthenia (GT), and Bernard-Soulier syndrome (SBS) are autosomal recessive rare platelet disorders, characterized by severe bleeding because of the absence, reduction or dysfunction of several glycoprotein receptor complexes in platelets. Both normal number and morphology of platelets characterize TG. However, platelet aggregation ability is seri ...
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 1

 TERMINÉ 

Role of LINE-1 retrotransposons in the human disease DiGeorge Syndrome (L1-DIGEORGESYNDROME)

Date du début: 1 juin 2012, Date de fin: 21 nov. 2016,

Long INterspersed Element 1 (LINE-1s or L1s) is a highly abundant retrotransposon comprising 17% of the human genome. Most L1s are retrotransposition defective, but there are approximately 100 full-length active L1s (RC-L1s) in an average human genome. The activity of RC-L1s impacts the human genome in a myriad of ways, and several human diseases have been caused by the activity of L1s.The Drosha- ...
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 1

 TERMINÉ 

Development and in vivo validation of a SPION based Theranostic nanosystem for the treatment of Metastatic Breast Cancer (MBCtheranosticSPION)

Date du début: 28 oct. 2014, Date de fin: 27 oct. 2016,

This project aims to develop a Theranostic Nanosystem allowing selective co-delivery of therapeutic agents with distinct physical chemical properties to target diseased cells in vivo. Besides good on-shelf and in vivo stability and low toxicity, the system must enable ratiometric control of cargo loading, avoid premature release of transported agents, allow controlled drug release at targeted loca ...
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 1

 TERMINÉ 

PAtients Leading and mANaging their healThcare through EHealth (PALANTE)

Date du début: 1 févr. 2012, Date de fin: 31 juil. 2015,

Patient empowerment is considered a potential tool to reduce healthcare costs and improve efficiency of the health systems, reinforcing healthcare quality. Patient empowerment has become an element of high priority in the EU health strategy, supported by national and regional health authorities.Building on already existing e-health platforms and services in the participating regions, the PALANTE p ...
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 21

 TERMINÉ 

LINE-1 retrotransposition in human somatic cells (SOMATIC_MOSAICISM)

Date du début: 12 juin 2013, Date de fin: 11 juin 2015,

The human genome is largely composed of non-coding DNA, only 3-5% codes for exons. The majority of the non-coding DNA is however fundamental for the correct functioning and regulation of the genome. Transposable elements (TEs) like LINEs generated up to 50% of the human genome during evolution. They can mobilize, causing mutations but also conferring genomic plasticity. The generation of new inser ...
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 1

 TERMINÉ 

Magnetic-PCR: An ultrasensitive methodology for Breast cancer detection and characterization (Magnetic_PCR)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,

The Magnetic-PCR project propose a brand-new and ultrasensitive methodology for detection and classification of breast cancer subtypes based on detection of specific genes expression. For this, the project develops a new “magnetic relaxation switch” (MRSw) biosensor based on superparamagnetic nanoparticles to improve the sensitivity of the Polymerase Chain Reaction (PCR) for detecting nucleic aci ...
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 1

 TERMINÉ 

Rehabilitative Wayout In Responsive home Environments (REWIRE)

Date du début: 1 oct. 2011, Date de fin: 31 déc. 2014,

Description The REWIRE project develops, integrates and field tests an innovative rehabilitation platform based on virtual reality. The platform allows patients, discharged by the hospital, to continue their intensive rehabilitation at home under remote monitoring by the hospital itself. The patient sees on the display himself or an avatar m ...
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 13

 TERMINÉ 

LINE-1 ACTIVITY IN SOMATIC STEM CELLS: IMPACT AND GENOMIC MOSAICISM (SOMATIC LINE-1)

Date du début: 24 juin 2008, Date de fin: 23 juin 2012,

"45% of the human genome is made of repeated DNA, and some types can be mobilized within the genome (mobile DNA). LINE-1 or L1 is the only autonomous active mobile DNA within the human genome, with 500.000 copies per haploid genome (~17% of the genome). Overall, L1 is responsible for ~30% of our genome. Due to its activity and number in the genome, the impact that L1 has and have on the genome is ...
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 1

 TERMINÉ 

Developmental Impact of MLL-AF4 Fusion Gene linked to Infant Acute Lymphoblastic Leukaemia on Human Stem Cell Fate (Leukaemogenesis)

Date de fin: 1 sept. 2009,

The MLL gene is located in chromosome 11q23 and is implicated in >40 different chromosomal translocations, generating distinct leukaemic fusion genes. Unlike other MLL fusion proteins, t(4;11) MLL-AF4 is always found in infant pro-B-ALL with a dismal prognosis in infants and adults. In infant ALL where t(4;11) MLL-AF4 is very common (>80%), the gene fusion arises in utero. However, very litt ...
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 1