3 projets européens trouvés
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TERMINÉ
Chromatin and MetabolismChromatin-metabolism interactions as targets for healthy living (ChroMe)
Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,
Metabolic disorders are at pandemic levels. Based on recent estimates, ~50% of Europeans are overweight, 20% are obese and 10% have type II diabetes. Obesity and insulin resistance impact European health to the tune of €110 billion per year. These disorders have genetic, nutritional and lifestyle causes. However, the molecular mechanisms that link nutrients and lifestyle to gene activity and chrom ...
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12
Participants partenaires
TERMINÉ
Cell of origin/Leukemia Initiating Cell in infant Pro-B MLL-AF4+ ALL (MODELING MLL-AF4 ALL)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2018,
"Infant pro-B acute lymphoblastic leukemia (ALL) carrying the fusion oncogene MLL-AF4 is associated with very brief latency and dismal prognosis. Recent studies have revealed an in utero origin of MLL-AF4 but the nature of the target cell for transformation in the embryo/fetus is unknown. Because of the mixed phenotype and the presence of MLL-AF4 in both lymphoid and myeloid lineages, hematopoieti ...
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1
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TERMINÉ
GENOMIC, CELLULAR AND DEVELOPMENTAL RECONSTRUCTION OFINFANT MLL-AF4+ ACUTE LYMPHOBLASTIC LEUKEMIA (INFANTLEUKEMIA)
Date de fin: 1 janv. 2016,
Infant cancer is very distinct to adult cancer and it is progressively seen as a developmental disease. An intriguing infant cancer is the t(4;11) acute lymphoblastic leukemia (ALL) characterized by the hallmark rearrangement MLL-AF4 (MA4), and associated with dismal prognosis. The 100% concordance in twins and its prenatal onset suggest an extremely rapid disease progression. Many key issues rema ...
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