5 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Proteomic investigations of ubiquitin signals in DNA repair and chromatin organization (PROTEUS)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,
"Genome integrity is constantly challenged by endogenous and environmental factors that can induce different types of DNA lesions. Failure to repair DNA lesions can lead to genomic instability and contribute to human diseases such as cancer and premature ageing. To counteract these potentially devastating effects caused by DNA damage, eukaryotic cells have evolved complex DNA repair pathways. Prot ...
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1
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TERMINÉ
Epigenetics towards systems biology (EPIGENESYS)
Date du début: 1 oct. 2010, Date de fin: 31 mars 2016,
The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is nee ...
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28
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TERMINÉ
Elucidating the role of DNA methylation in enhancer priming in vivo (ENHANCEME)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2016,
In recent years significant steps have been made in enhancer-biology. Studies investigating enhancers have revealed two classes of enhancers: active or primed. Despite this recent advance it is still largely unknown how epigenetic marks functionally interact and in which order events take place during enhancer priming in the early embryo. In order to address these questions I will study enhancers ...
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1
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TERMINÉ
Functions and mechanism of active DNA demethylation (DNADEMETHYLASE)
Date du début: 1 juin 2010, Date de fin: 31 mai 2015,
Epigenetic gene regulation is of central importance for development and disease. Despite dramatic progress in epigenetics during the past decade, DNA demethylation remains one of the last big frontiers and very little is known about it. DNA demethylation is a widespread phenomenon and occurs in plants as well as in animals, during development, in the adult, and during somatic cell reprogramming of ...
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2
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TERMINÉ
Small RNA Mediated Epigenetics in Vertebrates (EPIRNAS)
Date du début: 1 août 2008, Date de fin: 31 juil. 2014,
Since the discovery of RNAi small RNA molecules have been under intense study. They have been shown to impact many different processes, ranging from development to organ function and carcinogenesis. Recently, it has become clear that many distinct small RNA families exist. However, all act through a member of the well-conserved Argonaute family of proteins. I try to understand how specificity of t ...
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