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16 projets européens trouvés

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 TERMINÉ 

Nucleases in homologous recombination: from basic principles to genome editing (HRMECH)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

Homologous recombination plays a crucial role to repair DNA strand breaks that may occur spontaneously upon replication fork collapse, during the course of radio- or chemotherapy or in a programmed manner during meiosis. Understanding the molecular mechanisms of re-combinational repair is thus very important not only from a basic research viewpoint, but it is also highly relevant for human health. ...
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 1

 TERMINÉ 

European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates (EHVA)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the Eur ...
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 43

 TERMINÉ 

Structural, genetic and functional analyses of broadly neutralizing antibodies against human pathogens (BROADimmune)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2020,

The overall goal of this project is to understand the molecular mechanisms that lead to the generation of potent and broadly neutralizing antibodies against medically relevant pathogens, and to identify the factors that limit their production in response to infection or vaccination with current vaccines. We will use high-throughput cellular screens to isolate from immune donors clonally related an ...
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 1

 TERMINÉ 

"Dissecting the human T cell response to pathogens, allergens, and self-antigens" (PREDICT)

Date du début: 1 juil. 2013, Date de fin: 30 juin 2018,

"The overall goal of this project is to test, in the human system, several hypotheses related to the role of T helper (Th) subsets in immunity and immunopathology. Using an experimental approach that takes advantage of high throughput culture methods and combines the ex vivo analysis of memory T cells with the in vitro priming of naïve T cells, we will dissect the Th cell response to pathogens, al ...
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 1

 TERMINÉ 

Advanced Immunization Technologies (ADITEC)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2017,

Vaccines so far have been developed mostly by following an empiric approach. To prevent and possibly cure unresolved and emerging infectious diseases we need to fully exploit the potential of the human immune system. Progress in science and technology makes it possible to achieve what was previously deemed impossible. The scope of this project is to produce knowledge necessary to develop novel and ...
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 53

 TERMINÉ 

IMMUNE RESPONSES TO INFLUENZA VACCINE (IRINVAC)

Date du début: 1 août 2013, Date de fin: 31 juil. 2017,

"Influenza virus continues to represent a major global health problem and the recent pandemic caused by a H1N1 strain of influenza A (swine flu) is a good example of its potential global threat to health. Vaccination again influenza confers in most of the cases protection against the disease, mainly due to a robust humoral response. However, yearly vaccinations are required in order to protect aga ...
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 1

 TERMINÉ 

Anti-Biopharmaceutical Immunization:Prediction and analysis of clinical relevance to minimize the risk (ABIRISK)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

The ABIRISK project provides an integrated approach to the study of immunization against biopharmaceuticals, bringing together a unique panel of experts from different disciplines. ABIRISK will involve many of the European leaders in rheumatology, gastroenterology, hemophilia and multiple sclerosis, caring for ~30,000 patients treated with biopharmaceuticals, with ~10,000 additional patients recru ...
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 39

 TERMINÉ 

International Research Consortium on Dengue Risk Assessment, Management, and Surveillance (IDAMS)

Date du début: 1 sept. 2011, Date de fin: 28 févr. 2017,

The overall concept of this research project is to assemble a consortium of international experts working together to develop new and innovative tools to be applied to the control of dengue in a global context. The core of the application focuses on parallel strategies aimed at:• improving diagnosis and clinical management of dengue through two linked work packages designed a) to identify readily ...
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 18

 TERMINÉ 

TargetIng novel MEchanisms of Resolution in inflammation (TIMER)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

Resolution of inflammation is a key determinant of pathology, and an active process which involves diverse pathways and molecules. The general objective of the TIMER Consortium is to identify and validate new molecules involved in the resolution of inflammation as a basis for the development of innovative therapeutic strategies in chronic inflammatory and autoimmune diseases. The project will invo ...
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 13

 TERMINÉ 

New approaches to analyze and exploit the human B and T cell response against viruses (IMMUNEXPLORE)

Date du début: 1 sept. 2010, Date de fin: 31 août 2015,

Immunological memory confers long term protection against pathogens and is the basis of successful vaccination.Following antigenic stimulation long lived plasma cells and memory B cells are maintained for a lifetime,conferring immediate protection and enhanced responsiveness to the eliciting antigen. However, in the case ofvariable pathogens such as influenza virus, B cell memory is only partially ...
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 1

 TERMINÉ 

Rationally Designed Aquatic Receptors integrated in label-free biosensor platforms for remote surveillance of toxins and pollutants (RADAR)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

RADAR is a 7-member consortium that aims to develop a robust, sensitive, and versatile label-free, biosensor platform for spot measurements and on-line monitoring of toxins and pollutants in food production processes and in the aquatic environment.Specificity towards chemical pollutants and toxins is achieved by using recombinant receptors (namely the estrogen receptor and the aryl hydrocarbon rec ...
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 7

 TERMINÉ 

CD4 T AND B LYMPHOCYTES IN HEPATITIS B PATIENTS: ROLE IN ACUTE AND CHRONIC INFECTION (LINFOEPAB)

Date du début: 1 mai 2012, Date de fin: 30 avr. 2014,

"Hepatitis B virus (HBV), an hepatotropic non-cytopathic DNA virus, still represents a global health problem, with million of deaths for year because of complication of chronic infection. Chronic infection and its outcome are believed a consequence of defective antiviral response, mainly in T-cell arm, probably mediated by prolonged exposition to large amounts of viral antigens. Recently, many adv ...
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 1

 TERMINÉ 

Discovery and preclinical development of new generation tuberculosis vaccines (NEWTBVAC)

Date du début: 1 janv. 2010, Date de fin: 28 févr. 2014,

"With 14.4 million prevalent cases and 1.7 million deaths tuberculosis (TB) remains one of the most serious infectious diseases to date. An estimated 2 billion people are believed to be infected with Mycobacterium tuberculosis and at risk of developing disease. Multi- and extensively drug resistant strains are increasingly appearing in many parts of the world, including Europe. While with current ...
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 39

 TERMINÉ 

Identification of Mechanisms Correlating with Susceptibility for Avian Influenza (IMECS)

Date du début: 1 avr. 2008, Date de fin: 31 déc. 2012,

IMECS is a proposal of the FLUSECURE network aimed at combating the threat of new and re-emerging forms of highly pathogenic influenza in its first stages of a disease by identifying mechanisms of protection that are essential for a solid immune response to avian influenza. IMECS is uniquely featured by correlating research in humans directly to protection from influenza. The IMECS initiative was ...
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 8

 TERMINÉ 

Migration and Differentiation of Th17 Cells in HIV/SIV Infection (MD-THIV)

Date du début: 1 juin 2009, Date de fin: 31 janv. 2012,

"More than 25 years after the discovery of human immunodeficiency virus (HIV) as the causative agent of AIDS, the mechanisms governing pathogenesis and disease progression are still not fully understood. Indeed, a progressive impairment of the immune system, with alterations that affect both innate and adaptive immunity, characterizes the infection with HIV 1 in humans and with simian immunodefici ...
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 1

 TERMINÉ 

Pemphigus - From autoimmunity to disease (Pemphigus)

Date du début: 1 mai 2008, Date de fin: 31 oct. 2011,

Pemphigus is a potentially lethal bullous disease of the skin and mucosa and may be considered as a paradigmatic organ-specific autoimmune disease due to 1) its well-defined autoantigens, 2) the knowledge of critical events of its immune pathogenesis and 3) the reproducibility of major clinical and pathogenic features in suitable animal models. Overall, understanding the etiopathogenesis of pemphi ...
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 7