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Plus de 40 projets européens trouvés

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 TERMINÉ 

European Security in Health Data Exchange (SHiELD)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

SHiELD will unlock the value of health data to European citizens and businesses by overcoming security and regulatory challenges that today prevent this data being exchanged with those who need it. This will make it possible to provide better health care to mobile citizens across European borders, and facilitate legitimate commercial uses of health data.The exchange of health data is already possi ...
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 11

 TERMINÉ 

Personal Assistant for healthy Lifestyle (PAL) (PAL)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2019,

Type 1 Diabetes Mellitus (T1DM) portraits a high need and challenge for self-management by young patients: a complex illness with a high and increasing prevalence, a regimen that needs adaptation to patient’s condition and activities, and serious risks for complications and reduced life expectations. When patients do not acquire the knowledge, skills and habits to adhere to their diabetes regimen ...
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 12

 TERMINÉ 

Intelligent Sensor Enabled Eyewear (I-SEE)

Date du début: 1 juil. 2016, Date de fin: 30 sept. 2018,

...e I-See product line on the B2C consumer market, as well as the distinctive capabilities of the consortium partners in the electronics (SIGMA), SW (ALTEN), professional service (EY) and scientific (Fondazione Centro San Raffaele) fields, who will strengthen their B2B offer and positioning in the manufacturing industries impacted by the wearable trend. The project ambition is to launch the I-See pr ...
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 5

 TERMINÉ 

PRIvacy and Security MAintaining services in the CLOUD (PRISMACLOUD)

Date du début: 1 févr. 2015, Date de fin: 31 juil. 2018,

With a current volume of over USD 100 billion and annual growth rates of over 10%, the world-wide market for cloud computing can be considered as the major growth area in ICT. However, big companies and public authorities are reluctant to entrust their most sensitive data to external parties for storage and processing. The reason for their hesitation is clear: There exist no satisfactory approache ...
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 17

 TERMINÉ 

Social innovation and light electric vehicle revolution on streets and ambient (Silver Stream)

Date du début: 1 juin 2015, Date de fin: 31 mai 2018,

The SilverStream project addresses the challenges associated with sustainable and affordable personal mobility for the growing and ageing population in congested European cities. The project combines both ergonomic concepts conceived for elderly people and advanced automotive technologies that are quiet, clean, energy efficient and safe. The particular objectives of SilverStream are: i) specificat ...
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 10

 TERMINÉ 

Online Privacy Enforcement, Rights Assurance and Optimization (OPERANDO)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2018,

The goal of the OPERANDO project is to specify, implement, field-test, validate and exploit an innovative privacy enforcement platform that will enable the Privacy as a Service (PaS) business paradigm and the market for online privacy services.The OPERANDO project will integrate and extend the state of the art to create a platform that will used by independent Privacy Service Providers (PSPs) to p ...
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 9

 TERMINÉ 

empoWering prIvacy and securiTy in non-trusteD envirOnMents (WITDOM)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2017,

The advent of the Future Internet prompts fundamental transformations in whole ICT ecosystems, while bringing new opportunities to stakeholders in the availability and rational use of physical resources with large-scale savings in IT investments. It will also pose new security challenges especially for ensuring robust protection of privacy and integrity of personal information, which are a fundame ...
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 7

 TERMINÉ 

Trusted Apps for open CPS (TAPPS)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2017,

Open and smart cyber-physical systems (CPS) are considered to be the next revolution in ICT with enormous economic potential enabling novel business models for integrated services and products. In many areas of CPS devices, there is a strong trend towards open systems, which can be extended during operation instantly adding functionalities on demand. The main goal of the TAPPS (Trusted Apps for op ...
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 9

 TERMINÉ 

Adoptive engineered T cell Trials to Achieve Cancer Killing (ATTACK)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,

The aim of this research is to exploit technology for nucleic acid delivery through the clinical testing of adoptive engineered T cells to treat cancer. Recent innovative developments in cancer gene-immunotherapy have led to very encouraging early clinical results. However, the use of engineered T cells is a challenging and complex field with further development and more proof-of-principle trials ...
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 16

 TERMINÉ 

A Unified Approach to Evaluating Cellular Immunotherapy in Solid Organ Transplantation (THE ONE STUDY)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2017,

Preventing immunological rejection of transplanted organs without the need for long-term use of pharmacological immunosuppression is a primary objective in transplantation medicine. Reducing the need for immunosuppression would dramatically improve the outcome for transplant recipients and reduce health costs for society. The means to achieve this goal has not been realised with pharmacological or ...
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 16

 TERMINÉ 

PROBING THE ROLE OF SODIUM CHANNELS IN PAINFUL NEUROPATHIES (PROPANE STUDY)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,

Neuropathic pain is a frequent feature of peripheral neuropathy adversely impacting patients’ quality of life and increasing health care costs. Not all individuals with neuropathy develop pain and it is not possible to predict who is more or less susceptible among those with similar risk exposure. Inability to identify high-risk individuals and drug-responder patients and lack of drugs acting on t ...
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 9

 TERMINÉ 

Advanced Cell-based Therapies for the treatment of Primary ImmunoDeficiency (CELL-PID)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2016,

Primary immune deficiencies (PID) are inherited disorders of the adaptive and innate immune system marked by severe infections, autoimmunity and high risk of cancer. Treatment entails hematopoietic stem cell (HSC) transplantation from allogeneic donors, however in the absence of an HLA compatible donor, HSCT outcome is limited by delayed or suboptimal reconstitution and complications. SCID-X1 and ...
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 20

 TERMINÉ 

Imaging liver immunopathology by intravital microscopy (IVM): a new approach to study the pathogenesis of hepatitis B virus (HBV) infection (Liver IVM and HBV)

Date du début: 1 sept. 2010, Date de fin: 31 mars 2016,

Overall objective and Specific Aims. The overall objective of this proposal is to elucidate the pathogenesis ofHBV infection with the ultimate hope that this knowledge will lead to the development of new therapeuticstrategies to terminate persistent infection and its attendant costs and complications. Our approach is to dissectpoorly understood cellular and molecular pathways responsible for both ...
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 2

 TERMINÉ 

Towards Safe and Effective Hematopoietic Stem Cell Gene Therapy: Targeting Integration to Genomic Safe Harbors and Exploiting Endogenous microRNA to Regulate Transgene Expression (TARGETINGGENETHERAPY)

Date du début: 1 mai 2010, Date de fin: 31 janv. 2016,

Hematopoietic stem cell gene therapy has a tremendous potential to treat human disease. Yet, in conjunction with the first successful results in the clinic, severe adverse events linked to the gene transfer protocol were reported. Recently, we provided proof-of-principle of two new powerful strategies to improve the efficacy and safety of gene transfer: 1) regulating transgene expression by exploi ...
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 3

 TERMINÉ 

Combined Highly Active Anti-retroviral Microbicides (CHAARM)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,

This proposal is for a large scale collaborative project in which we propose both to develop novel microbicides directed against new intracellular targets and to investigate novel combinations of highly active anti-retroviral drugs which may be particularly effective as microbicides. Combinations may enhance efficacy but equally importantly will increase the genetic barrier to the development of r ...
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 34

 TERMINÉ 

Beta Cell Therapy in Diabetes (BETACELLTHERAPY)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,

Type 1 diabetes is a serious chronic disease with major health risks and heavy burden on patients and society. It is caused by massive immune-mediated loss of insulin-producing beta cells in the pancreas that can so far not be locally corrected. A cellular allotransplant in the liver can install a new beta cell mass but the size is insufficient and the procedure faces limitations of donor shortage ...
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 18

 TERMINÉ 

Visualizing liver immunopathology progression during hepatitis B infection by liver Intravital Microscopy (IVM) (Liver IVM)

Date du début: 6 mai 2013, Date de fin: 5 mai 2015,

Hepatitis B virus (HBV) and hepatitis C virus (HCV) infect the liver, and are unique in their capacity to cause persistent infection, cirrhosis, and liver cancer. The lack of experimental approaches to study these infections, due to the limited host range to humans and chimpanzees, have hampered the understanding of fundamental issues regarding their pathogenesis. It is now clear that both infecti ...
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 1

 TERMINÉ 

Effect of PTPN22 on Treg to Teff equilibrium in human and murine autoimmune diabetes (PTPN22 in T1D)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,

"Type 1 diabetes (T1D) is a chronic inflammatory disease, where predisposing genetic factors along with environmental influences result in loss of immunological tolerance and destruction of insulin-producing beta cells. Genetic studies have identified three main T1D susceptibility loci, the human leukocyte antigens (HLA), insulin and most recently PTPN22, which encodes for Lyp/Pep, a lymphoid tyro ...
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 2

 TERMINÉ 

EUROCANCER STEMCELL TRAINING NETWORK (EuroCSCTraining)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

The recent identification of tumor initiating (TIC) or cancer stem cells (CSC) has opened a new area of research for scientists interested in cancer. Understanding the biology of cancer stem cells has already unraveled pathways and potential targets. However, accumulating data has underscored the complexity of the CSC research area and prompts hence the need for well-structured networks to provid ...
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 11

 TERMINÉ 

Intelligent Surgical Robotics (I-SUR)

Date du début: 1 mars 2011, Date de fin: 31 déc. 2014,

Description I-SUR will develop advanced technologies for automation in minimally invasive and open surgery. Currently, automation is not used in the operating room for a number of technical and legal reasons, but it may provide a solution to improve performance and efficiency without increasing operating costs. I-SUR aims at breaking new gro ...
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 9

 TERMINÉ 

Activation of vasculature associated stem cells and muscle stem cells for the repair and maintenance of muscle tissue (Endostem)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,

We propose to develop new strategies to mobilize skeletal muscle tissue-associated stem cells as a tool for efficient tissue repair. This will be combined with exploring novel approaches that limit tissue damage, and will focus on agents that modify muscle and muscle vasculature progenitor cells. These molecules include nitric oxide associated with non-steroidal anti-inflammatory drugs, HMGB1, Cri ...
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 22

 TERMINÉ 

Tie2-expressing monocytes: Role in tumor angiogenesis and therapeutic targeting (Tie2+Monocytes)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2014,

Recent data indicated that tumor-infiltrating myeloid cells promote tumor angiogenesis. We contributed to this concept by showing that Tie2-expressing monocytes (TEMs) have a requisite role in this process. Indeed, the specific elimination of TEMs inhibits tumor angiogenesis and growth in several models. Yet, little is known of the biological bases of TEMs activity in tumors. Building upon my prev ...
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 2

 TERMINÉ 

Adaptive Strategies for Sustainable Long-Term Social Interaction (ALIZ-E)

Date du début: 1 mars 2010, Date de fin: 31 août 2014,

Description From theory to practice: Methods for an adaptive and prolonged child-robot interaction The goal of ALIZ-E is to develop novel methods for developing and testing interactive, mobile robots which will be able to socially interact with human users over extended periods of time, i.e. a pos ...
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 12

 TERMINÉ 

Aberrant gene expression and muscular dystrophy: role of non-coding RNAs and alternative splicing in the pathogenesis and potential therapies (NCRNAS-SPLICING-FSHD)

Date du début: 1 sept. 2008, Date de fin: 31 août 2014,

Our goal is to characterize the molecular pathogenesis of facioscapulohumeral muscular dystrophy (FSHD) in order to develop possible therapeutic approaches. FSHD is the third most important myopathy. Currently, no therapeutic treatment is available for FSHD. Unlike the majority of genetic diseases, FSHD is not caused by mutation in a protein-coding gene. Instead, FSHD is the result of a complex ep ...
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 2

 TERMINÉ 

Targeting the tumour microenvironment to improve pancreatic cancer prognosis (EPC-TM-Net)

Date du début: 1 févr. 2011, Date de fin: 31 juil. 2014,

Pancreatic cancer is one of the most lethal human cancers with a five-year survival rate of less than 5%. Late presentation and a high level of resistance to chemotherapeutic drugs are among the major reasons for this dismal prognosis. The presence of the highest degree of desmoplasia among all solid tumours and the fact that chronic inflammatory pancreatic disease is associated with an increased ...
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 17

 TERMINÉ 

Pan-European network for the study and clinical management of drug resistant tuberculosis (TB PAN-NET)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2014,

"This proposal will establish an integrated and synergistic network to address the challenge of multiple drug resistant tuberculosis (MDR-TB) facing the EU. The objective will be attained through the establishment of a European consortium of expert partners with extensive experience in the conduct of basic and clinical research relating to MDR-TB, TB control and epidemiology. This Consortium will ...
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 32

 TERMINÉ 

Immunomodulatory Effects of Exercise in Type 1 Diabetes (IMMEEDIA)

Date du début: 1 juil. 2010, Date de fin: 30 juin 2014,

"Diabetes is a major metabolic disease with huge costs for healthcare system throughout the EU and worldwide. Type 1 Diabetes (T1DM) is a chronic condition in which pancreas produces little or no insulin, believed to result from a disorder of immunoregulation. For decades it has been known that regular aerobic exercise improves insulin sensitivity in diabetic patients, reducing insulin requirement ...
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 5

 TERMINÉ 

Role of secretases in myelination (Secretases & Myelin)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2014,

The development of glial cells, oligodendrocytes (OL) in CNS and Schwann cells (SC) in PNS, critically depends on axonal contact. Gliogenesis and the phenotype of myelinating glia are regulated by axons. Glial cells promote neuronal survival, regulate the organization of myelinated axons and promote axonal differentiation and myelin sheath production.We recently showed that type III NRG1, a member ...
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 2

 TERMINÉ 

Quantifying transcription factor search mechanism by three-dimensional single molecule tracking (SMT of TFs)

Date du début: 16 avr. 2012, Date de fin: 15 avr. 2014,

Transcription factors (TFs) are capable to identify their target sites on DNA in a extremely efficient fashion. The observation that a simple 3D diffusion search cannot account for such efficient targeting has led to different mechanisms to be proposed in the last decades, including compact exploration induced by facilitated diffusion (i.e. combination of 1D sliding and 3D diffusion) or by fracta ...
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 2

 TERMINÉ 

Novel strategies for the cell therapy of muscular dystrophies (Stem cells for DMD)

Date du début: 1 mars 2009, Date de fin: 28 févr. 2014,

This project aims to develop an effective cell therapy for Duchenne Muscular Dystrophy (DMD). To reach this goal we plan to transfer a human artificial chromosome containing the whole dystrophin locus into dystrophic mesoangioblasts. As the transfer is inefficient and requires selection, it is impossible to use primary cells that would undergo senescence during selection. Therefore we need to rev ...
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 3

 TERMINÉ 

Optimization of stem cell therapy for clinical trials of degenerative skin and muscle diseases (OptiStem)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2013,

This proposal aims to develop and implement efficacy of clinical trials with adult, tissue stem cells for degenerative diseases of epithelia and skeletal muscle. Extraordinary progress in the understanding of several key features of stem cells has been rapidly translated into novel cell therapy protocols that have yielded positive results in pre-clinical models of genetic and acquired diseases and ...
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 20

 TERMINÉ 

Linking research organisations in the fields of Tissue Engineering and Regenerative Medicine through European cooperation between regional research clusters (TERM)

Date du début: 1 oct. 2010, Date de fin: 30 sept. 2013,

"The development of innovative 'Advanced Therapies' offers new approaches to tackle major diseases such as cancer, diabetes, Alzheimer or Parkinson. The progress made in the fields of 'Tissue Engineering' and 'Regenerative Medicine' (TERM) promises to deliver long awaited new solutions. They are recognized as potential sources for medical progress and significant economic growth where Europe shoul ...
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 16

 TERMINÉ 

Advanced Teaching and TRaining for Adoptive Cell Therapy (ATTRACT)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

Considerable resources are devoted to fighting cancer throughout Europe, yet these efforts are not producing the results that health practitioners and citizens might expect. This is partly due to the fragmentation and duplication of research efforts within Member states and the lack of co-ordination at European level. However it can also be attributed to the need to retain and most importantly dev ...
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 16

 TERMINÉ 

Leukemic Stem Cells in Chronic Lymphocytic Leukemia (LSC CLL)

Date du début: 1 oct. 2010, Date de fin: 30 sept. 2013,

"B cell Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in western countries. Although substantial therapeutic improvements have been obtained, the disease is incurable and causes 4000 deaths/year in the sole USA.We plan to in vivo evaluate CLL B cells division by measuring Deuterium (2H) incorporation into newly synthesized DNA. 2H given to patients in the form of deuterated water ...
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 1

 TERMINÉ 

Novel therapeutic antibodies for multiple myeloma (MMSC)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

"Multiple Myeloma (MM) is an incurable plasma cell neoplasm with a median survival of 3 years. A critical step towards the development of more effective therapies is the identification of dominantly acting oncogenes. We have implemented an integrated oncogenomic approach that utilizes high-resolution gene-specific array-CGH and comprehensive expression profiling to identify the spectrum of geneti ...
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 2

 TERMINÉ 

Trustworthy Clouds – Privacy and Resilience for Internet-scale Critical Infrastructure (TCLOUDS)

Date du début: 1 oct. 2010, Date de fin: 30 sept. 2013,

Protecting critical infrastructures providing communications, energy, or healthcare presents increasing ICT challenges as ICT itself has become vital to them. Internet-scale ICT infrastructures ("infrastructure clouds") promise scalable virtualised computing, network, and storage resources over the Internet. They provide scalability and cost-efficiency but pose significant new privacy and resilien ...
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 16

 TERMINÉ 

Therapeutic challenge in Leukodystrophies: Translational and ethical research towards clinical trials (LEUKOTREAT)

Date du début: 1 mars 2010, Date de fin: 31 août 2013,

Leukodystrophies (LDs) are inherited rare neurodegenerative diseases of the white matter and its main component, the myelin, that are affecting predominantly children. Severity of the disease is related to the axonal dysfunction due to myelin deficiency or destruction. Despite the achievement of remarkable advances made in the past decade, there is no current curative therapy. The development of t ...
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 25

 TERMINÉ 

Novel Approaches to Bacterial Target Identification, Validation and Inhibition (NABATIVI)

Date du début: 1 févr. 2009, Date de fin: 31 juil. 2013,

Despite the advent of the antibiotic era, infectious diseases retain their pre-eminent position as major worldwide causes of morbidity and mortality. This problem has been worsen by the emergence of multi-antibiotic resistant bacteria and the failure of Pharmaceutical company drug discovery programmes to design antibiotics with truly novel modes of action. NABATIVI has put together a unique consor ...
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 10

 TERMINÉ 

Experiential Living Lab for the Internet Of Things (ELLIOT)

Date du début: 1 sept. 2010, Date de fin: 30 juin 2013,

The ELLIOT project aims to develop an Internet Of Things (IOT) experiential platform where users/citizens are directly involved in co-creating, exploring and experimenting new ideas, concepts and technological artefacts related to IOT applications and services. ELLIOT will allow studying the potential impact of IOT and the Future Internet in the context of the Open User Centred Innovation paradigm ...
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 13

 TERMINÉ 

Persisting Transgenesis (PERSIST)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2013,

"For many disabling or fatal diseases, there is pre-clinical or clinical evidence of the potential therapeutic efficacy of gene therapy and, yet, the limitations of current gene transfer technologies have prevented success or even caused serious adverse events leading to termination of trials. PERSIST will explore the use of highly innovative gene-modifying and delivery technologies and capitalize ...
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 29