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Longitudinal analysis to study neurodegenerative diseases mechanisms in specific neuronal subtypes (Neuronal Specificity)
Date du début: 1 mai 2009, Date de fin: 30 avr. 2013,
Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD) are the most common human neurodegenerative diseases. Each features an abnormal accumulation of proteins, but whether the aggregation leads to neuronal death is controversial. HD is caused by a single mutation that increases the number of CAG repeats. Mutant huntingtin (htt) forms intraneuronal inclusion bodies (IBs). ...
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