3 projets européens trouvés
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TERMINÉ
Identification and therapeutic targeting of common arrhythmia trigger mechanisms (EUTRIGTREAT)
Date du début: 1 oct. 2009, Date de fin: 31 mars 2015,
Arrhythmias are common manifestations of heart disease which frequently cause sudden cardiac death (SCD) or other devastating health problems. In Europe, prevention of SCD by device and drug therapy is expensive and increasingly strains public health resources due to a growing population at risk. However, identification of patients at increased risk for SCD is ineffective, and SCD prevention strat ...
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15
Participants partenaires
TERMINÉ
HUMAN INDUCED PLURIPOTENT STEM CELLS AS A MODEL TO STUDY METABOLIC INHERITED LIVER DISEASES (IPSMILD)
Date du début: 1 déc. 2011, Date de fin: 30 nov. 2014,
"Familial hypercholesterolemia type IIa (FH) is a life-threatening disease caused by mutations on the Low Density Lipoprotein Receptor (LDLR). While drug treatments reduce the level of circulating cholesterol in heterozygote patients (1:500) with variable efficiency, homozygote patients (1:106) can only be treated by bimonthly apheresis, an invasive procedure. Hepatocytes are the only cells capabl ...
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1
Participant partenaire
TERMINÉ
Personalised and intergrated cardiac care: \nPatient-specific Cardiovascular Modelling and Simulation for In Silico Disease Understanding and Management (euHeart)
Date du début: 1 juin 2008, Date de fin: 30 nov. 2012,
Cardiovascular disease (CVD) has a significant impact on the European society in terms of mortality, morbidity and allied healthcare costs. The opportunity of multi-scale modelling spanning, sub-cellular level up to whole heart is to improve CVD outcomes by providing a consistent, biophysically-based framework for the integration of the huge amount of fragmented and inhomogeneous data currently av ...
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