6 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
SYSTEMS BIOLOGY OF PATHWAYS INVOLVING BRAIN AGEING (AGEDBRAINSYSBIO)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,
In spite of valuable approaches applied to get a broad understanding of genetic, epidemiologic and molecular and system-level biological principles of human aging, cognitive decline remains as one of the greatest health challenges of the old age, with nearly 50% of adults over 85 afflicted of Alzheimer’s disease. Furthermore, drug development has not performed as expected in clinical trials, at le ...
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15
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TERMINÉ
Crosstalk of epithelial lymphocytes and microbiota in influencing immunity and metabolism (Epithelial_Immunol)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2016,
This proposal aims to study the interactions between specialised cells of the immune system, the intra-epithelial cells (IELs) which are ideally positioned in close proximity of the epithelial cells, and the intestinal microbiota.It aims to provide insights into how IELs are able to maintain tolerance to beneficial bacteria while enhancing immune responses against undesirable ones. This will be ac ...
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1
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TERMINÉ
Protein Binders for Characterisation of Human Proteome Function: Generation, Validation, Application (AFFINOMICS)
Date du début: 1 avr. 2010, Date de fin: 31 mars 2015,
The Affinomics programme aims to leverage existing efforts in Europe to generate large-scale resources of validated protein-binding molecules (‘binders’) as affinity reagents for characterisation of the human proteome and to apply them in comprehensive structural and functional analyses of protein expression, interactions and complexes. Proteome targets will be focused on five categories of inter- ...
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20
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TERMINÉ
Synaptic Systems: dissecting brain function in health and disease (SYNSYS)
Date du début: 1 juil. 2010, Date de fin: 31 déc. 2014,
Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and ...
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19
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TERMINÉ
Lipid droplets as dynamic organelles of fat deposition and release: Translational research towards human disease (LipidomicNet)
Date du début: 1 mai 2008, Date de fin: 31 oct. 2012,
Lipids are central to the regulation and control of cellular processes by acting as basic building units for biomembranes, the platforms for the vast majority of cellular functions. Recent developments in lipid mass spectrometry have set the scene for a completely new way to understand the composition of membranes, cells and tissues in space and time by allowing the precise identification and quan ...
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27
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TERMINÉ
a Study of the Epigenetic Alterations that Result in Cardiac Hypertrophy (SEARCH)
Date du début: 1 avr. 2010, Date de fin: 31 mars 2012,
"Heart failure is a major cause of mortality and morbidity, and often the consequence of pathological cardiac hypertrophy. Upon entering hypertrophy, cells undergo a vast transcriptional remodelling, with thousands of genes being either up- or down-regulated. In the last years it became evident that epigenetic modifications are an important determinant of transcriptional changes, and several lines ...
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