3 projets européens trouvés
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TERMINÉ
Phylogeography and somatic evolution of cancer tumor cells (PHYLOCANCER)
Date du début: 1 oct. 2014, Date de fin: 30 sept. 2019,
"By far, most evolutionary research has focused on the changes that occur in the germline of individuals across generations, within and between species. For different reasons, much less attention has been given to the process of change within the somatic line of a multicellular individual. The formation of cancer tumors due to uncontrolled cell proliferation is one of the most prominent forms of s ...
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4
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TERMINÉ
Validating predictive models of radiotherapy toxicity to improve quality-of-life and reduce side-effects in cancer survivors (REQUITE)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
Long-term side-effects of radiotherapy impact on the quality-of-life (QoL) of cancer survivors. These side-effects could be reduced if predicted in advance. Previous work identified clinical and biological predictors but a major, coordinated approach is needed to validate them so they can be used clinically. The EU has ~17.8 million people living with a prior diagnosis of cancer of whom ~7 million ...
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15
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TERMINÉ
Personalized bioinformatics for global cancer susceptibility identification and clinical management (PanCanRisk)
Date du début: 1 juil. 2015, Date de fin: 30 juin 2018,
Cancer sequencing studies have extensively investigated the landscape of somatic mutations that drive tumor development, however the importance of germline variation for cancer susceptibility has been neglected. We hypothesize that for cancer types affecting a large proportion of the population, a shared set of genes with variants of different levels of penetrance leads to the clinical phenotype. ...
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