13 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients (MyNano)
Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,
Research on anticancer therapies has provided little progress towards improved survival rates for patients with metastatic disease. The intrinsic advantages of polymer conjugates can be optimised to rationally design targeted combination therapies, concept I pioneered that allows enhanced therapeutic efficiency. Early clinical trials involving conjugates showed activity in chemotherapy refractory ...
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1
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TERMINÉ
Exploiting Protein Complexes that Induce Cell-death (EPIC)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,
The formation of specific protein complexes are key events in life-and-death decisions made by cells. Inappropriate decisions underpin a plethora of disease conditions from degenerative diseases to cancer while the role of the complexes in these processes make them important therapeutic targets. Our ability to develop small molecules to target death-inducing protein complexes has been hampered by ...
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5
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TERMINÉ
ELIXIR-EXCELERATE: Fast-track ELIXIR implementation and drive early user exploitation across the life-sciences. (ELIXIR-EXCELERATE)
Date du début: 1 sept. 2015, Date de fin: 31 août 2019,
The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that scienc ...
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47
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TERMINÉ
Developing an European American NGS Network (DEANN)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,
The DEANN project is a network formation initiative that involves six research institutions and universities from four EU countries and equivalently, six research entities from four Latin American countries. The overall goal is to strengthen research partnership among the participants by developing a shared scientific knowhow in the field of Next Generation Sequencing data analysis. More specific ...
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7
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TERMINÉ
Machine Learning for Personalized Medicine (MLPM2012)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,
"Over the last decade, enormous progress has been made on recording the health state of an individual patient down to the molecular level of gene activity and genomic information – even sequencing a patient’s genome for less than 1000 dollars is no longer an unrealistic goal. However, the ultimate hope to use all this information for personalized medicine, that is to tailor medical treatment to th ...
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11
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TERMINÉ
Joining up ICT and service processes for quality integrated care in Europe (SmartCare)
Date du début: 1 mars 2013, Date de fin: 31 août 2016,
Against the background of the European Innovation Partnership on Active & Healthy Ageing, SmartCare aims to define a common set of standard functional specifications for an open ICT platform enabling the delivery of integrated care to older European citizens. A total of 24 regions and their key stakeholders will define a comprehensive set of integration building blocks around the challenges of dat ...
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46
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TERMINÉ
European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR)
Date du début: 1 mars 2012, Date de fin: 30 juin 2016,
Diabetic retinopathy (DR), the leading cause of blindness among working-age individuals in developed countries has been classically considered to be a microcirculatory disease of the retina. However, there is growing evidence to suggest that retinal neurodegeneration is an early event in the pathogenesis of DR. For this reason, it is reasonable to hypothesize that therapeutic strategies based on n ...
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18
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TERMINÉ
Developmental neurotoxicity assessment of mixtures in children (DENAMIC)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
Various recent epidemiological studies have indicated that exposure to low doses of environmental biologically active contaminants during human development can alter gene expression and have deleterious effects on cognitive development in childhood. The DENAMIC project is ultimately focused on reducing such effects of environmental contamination on learning and developmental disorders in children. ...
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18
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TERMINÉ
User-driven Development of Statistical Methods for Experimental Planning, Data Gathering, and Integrative Analysis of Next Generation Sequencing, Proteomics and Metabolomics data (STATegra)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2015,
Users of NGS technologies, producing large and numerous distinct types of omics data, demands statistical methods to combat data and knowledge fragmentation and inappropriate procedures for data analysis. Yet, the current a gap between the available tools for analysis of a single omics data-type versus the requirement of biomedical scientists to understand the integrated results derived from sever ...
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11
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TERMINÉ
Innovative strategies to generate human hepatocytes for treatment of metabolic Liver diseases: Tools for personalized cell therapy (InnovaLiv)
Date du début: 1 déc. 2011, Date de fin: 30 nov. 2014,
Transplantation of donor hepatocytes has become an alternative to liver transplantation for the treatment of liver diseases. However, in addition to the complication imposed by severe shortage of donor livers, adult hepatocytes cannot be expanded in vitro. Autologous transplantation of genetically corrected hepatocytes represents another strategy as it circumvents the need for immunosuppression bu ...
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7
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TERMINÉ
Light-based functional in vivo monitoring of diseases related enzymes (LIVIMODE)
Date du début: 1 nov. 2009, Date de fin: 30 avr. 2013,
"LIVIMODE aims to develop specific tools for non invasive in vivo imaging of disease related molecular events. Such tools are of high relevance for disease detection, staging, developing animal models of human disease, and evaluating novel therapies. We propose to use optical imaging, which is optimally suited for this task as it provides excellent sensitivity and allows visualizing molecular even ...
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13
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TERMINÉ
Development of culture conditions for the differentiation of hES cells into hepatocytes (LIV-ES)
Date du début: 1 oct. 2008, Date de fin: 31 mars 2012,
"The liver is associated with many types of diseases which can only be treated by Orthotopic liver transplants. However, shortage of organ donors represents a major limitation for wide-application of this therapy. Additionally, expansion of fully-functional hepatocytes in vitro remains an important challenge for the drug discovery industry. Human Embryonic Stem cells (hESCs) offer a promising new ...
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7
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TERMINÉ
Elucidation of Stem Cell Fate and Cell-type Characterization by 1H-NMR-based Metabonomics (hESC Metabonomics)
Date du début: 1 juil. 2008, Date de fin: 30 juin 2010,
Human Embryonic Stem Cells (hESCs) harbour the extraordinary ability to self-renew and differentiate into cells of all tissue types and thus, hold great promise for the treatment of a range of diseases. Mechanisms controlling hESC fate are yet to be elucidated but are believed to involve regulation by intrinsic and extracellular metabolic factors including hormones, growth factors and small cell-p ...
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