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 TERMINÉ 

4D analysis of heart development and regeneration using advanced light microscopy (4DHeart)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Cardiovascular (CV) disease is a main cause of death worldwide. During adulthood, ischemic heart disease leads to heart failure and perinatally, congenital heart defects are found in over 20% of deaths. Moreover, genetic or epigenetic factors altering development can have an impact much later in life. These facts underscore the need of a better understanding of the genetic and environmental factor ...
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 7

 TERMINÉ 

YOUNGatHEART: CARDIAC REJUVENATION BY EPIGENETIC REMODELLING (YOUNGatHEART)

Date du début: 1 nov. 2015, Date de fin: 1 nov. 2020,

Aging poses the largest risk for cardiovascular disease (CVD) and is orchestrated, to some extent, by epigenetic changes. Despite the significant progress on many fronts in the cardiovascular field, non-inherited epigenetic regulation in cardiac aging and CVD remains unexplored. Dilated Cardiomyopathy (DCM) is a major contributor to healthcare costs and it is the leading indication for heart trans ...
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 1

 TERMINÉ 

Molecular strategies to treat inherited arrhythmias (EU-rhythmy)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,

Sudden cardiac death (SCD) is a leading cause of death in western countries: coronary artery disease is the major cause of SCD in older subjects while inherited arrhythmogenic diseases are the leading cause of SCD in younger individuals. After 25 years dedicated to research of the molecular bases of heritable arrhythmias, the PI of this proposal now intends to pioneer gene therapy for prevention o ...
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 3

 TERMINÉ 

Professional cross-priming for ovary and prostate cancer (PROCROP)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Immune responses are initiated by antigen presentation mediated by dendritic cells (DC). There is a minority subset of DC highly specialised in starting up cytotoxic T lymphocytes able to kill tumor cells. PROCROP aims to develop in three pilot clinical trials a suitable individualized cancer vaccine technology for castration resistant prostate cancer and metastatic cancer of the ovary that would ...
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 8

 TERMINÉ 

Secondary prEvention of CardiovascUlaR disease in the Elderly trial (SECURE)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

While Cardiovascular diseases (CVD) are the main cause of death worldwide, they are responsible for half of all deaths in Europe. The overall ageing of the European population and improving survival of patients with coronary heart disease has created a large population of older adults eligible for secondary prevention. Despite the established efficacy of cardiovascular medications, suboptimal adhe ...
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 13

 TERMINÉ 

Epistasis analysis of angiogenes with high cellular definition (AngioGenesHD)

Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,

Blood and lymphatic vessels have been the subject of intense investigation due to their important role in cancer development and in cardiovascular diseases. The significant advance in the methods used to modify and analyse gene function have allowed us to obtain a much better understanding of the molecular mechanisms involved in the regulation of the biology of blood vessels. However, there are tw ...
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 1

 TERMINÉ 

Comprehensive Lifestyle Intervention Project (CLIP) (CLIP)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

Cardiovascular disease (CVD) incidence continues to rise at an alarming rate largely as a consequence of behavioural risk factors. The only way to tackle this epidemic is to implement preventive strategies before the disease appears. Current evidence suggests that conventional approaches are inadequate for promoting healthier lifestyles, and therefore implementation of novel methods is desperately ...
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 1

 TERMINÉ 

Novel insights into cardiac regeneration through studies in the zebrafish (zebraHeart)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Myocardial infarction (MI) leads to cardiomyocyte death and accumulation of myofibroblasts (MFs) at the site of injury, which produce large amounts of extracellular matrix (ECM), generating a scar. Initially, cardiac fibrosis protects from ventricular wall rupture, but subsequent myocardial remodelling causes heart failure, representing a leading cause of death in Europe. While MFs play a central ...
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 2

 TERMINÉ 

Biochemical and mechanochemical mechanisms in polarized cells (BIOPOL)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

BIOPOL is an interdisciplinary European training network at the interface of cell biology, physics and engineering. BIOPOL aims specifically at the understanding of fundamental mechanochemical principles guiding cellular behaviour and function and their relevance to human disease. A new supra-disciplinary research field is emerging bringing together the fields of molecular cell biology, physics an ...
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 10

 TERMINÉ 

CNIC International Postdoctoral Programme (CNIC IPP)

Date du début: 3 juin 2013, Date de fin: 2 juin 2018,

"The proposed CNIC International Postdoctoral Programme (CNIC IPP) is aimed at supporting trans-national mobility of postdoctoral researchers and to broaden and deepen their individual competence, particularly in terms of acquisition of complementary skills needed to become an independent group leader in the future.The programme offers fellowships for researchers who hold a PhD Degree at the time ...
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 1

 TERMINÉ 

Molecular mechanisms regulating cardiovascular remodeling by Adamts1 (MERC)

Date du début: 1 juin 2016, Date de fin: 31 mai 2018,

Professor Redondo’s group has recently identified Adamts1 as one of the major mediators in vascular wall remodeling. They showed that Adamts1+/-, Adamts1-/- and KD-Adamts1 mice present aortic dilation, aneurysms, medial degeneration and hypotension, leading to the hypothesis that Adamts1 deficiency results in a new familial form of thoracic aortic aneurysm (FTAAD) potentially relevant in human aor ...
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 1

 TERMINÉ 

APERIM: Advanced bioinformatics platform for PERsonalised cancer IMmunotherapy (APERIM)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2018,

Cancer treatment platforms that involve the use of the adaptive immune system have demonstrated profound tumour regressions including complete cure. Importantly, technological advances in next-generation sequencing (NGS) allow for the first time the development of personalised cancer immunotherapies that target patient specific mutations. However, clinical application is currently hampered by spec ...
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 11

 TERMINÉ 

microRNA replacement therapy for mature B cell neoplasias (HEAL-BY-MIRNA)

Date du début: 1 mai 2016, Date de fin: 31 oct. 2017,

Mature B cell neoplasias include most of Non-Hodgkin Lymphomas (NHL), such as Diffuse Large B Cell Lymphomas and Burkitt Lymphoma and also B cell Chronic Lymphocytic Leukemia. It is estimated that about 60000-80000 new cases of mature B cell neoplasias are diagnosed every year in Europe. About 60% of NHL present with aggressive forms, and need immediate therapeutic action. The most common choice o ...
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 1

 TERMINÉ 

Next generation training in cardiovascular research and innovation (CardioNext)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

CardioNext is an innovative training proposal organised by researchers at the Spanish National Centre for Cardiovascular Research (CNIC) to achieve three key aims. (i) Recruit talented and motivated graduate students to be trained as a new generation of translational researchers in cardiovascular disease. (ii) Create a well-developed and inter-connected network of academic scientific researchers a ...
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 1

 TERMINÉ 

COMBINATIONAL USE OF INNATE IMMUNE RECEPTORS FOR CANCER IMMUNOTHERAPY (PRR IN IMMUNOTHERAPY)

Date du début: 1 juin 2013, Date de fin: 31 mai 2017,

Cancer is a major scientific and economical challenge that our society has to face and new therapeutic approaches should now be evaluated in order to decrease human and financial cost of this disease. After suffering from many drawbacks, cancer immunotherapy, which aims at mobilizing the immune system to fight cancer, has recently gained enthusiasm with the completion of several randomized phase I ...
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 1

 TERMINÉ 

Mechanisms of MTOC guidance and Genetic Transfer at the Immune Synapse: novel modes of Immuno-modulation (GENTRIS)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,

"Cell-cell synapses are an exquisitely evolved means of communication between cells. During the formation of the immune synapse (IS), diverse transmembrane and membrane associated molecules are reorganized into a highly segregated structure at the T cell–Antigen-Presenting Cell (APC) contact site. As part of this process, the tubulin cytoskeleton is vectorially directed toward the center of the IS ...
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 2

 TERMINÉ 

Clot formation as a potential diagnostic tool and therapeutic target for Alzheimer's disease (ADvasculature)

Date du début: 15 janv. 2015, Date de fin: 14 janv. 2017,

Alzheimer’s disease (AD) is the leading cause of dementia in the elderly. Accumulating evidence links AD with vascular risk factors. These correlations, together with profound alterations of cerebrovascular structure and function present in AD, suggest a “vascular hypothesis”, where vascular pathology eventually leads to neurodegeneration and subsequent cognitive decline. A decrease in cerebral bl ...
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 1

 TERMINÉ 

Mitochondrial European Educational Training (MEET)

Date du début: 14 janv. 2013, Date de fin: 13 janv. 2017,

"The expanding diversification and specialization of knowledge and the growing complexity of contemporary research in translational research warrant the creation of cooperative multi-disciplinary networks including both basic and medically oriented expertise. This notion is especially true for Mitochondrial Medicine which aims at understanding the physiopathological mechanisms sharing the features ...
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 10

 TERMINÉ 

Role of obesity in the development of hepatocellular carcinoma (OBECAN)

Date du début: 1 déc. 2010, Date de fin: 30 nov. 2016,

Obesity is associated with increased risk for epithelial tumors such as hepatocellular carcinoma (HCC). It is not known, however, whether obesity increases the risk for HCC simply because it promotes cirrhosis, a general risk factor for HCC, or through other mechanisms that operate independently of cirrhosis. Among these, obesity is associated with a chronic inflammatory state, with the release of ...
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 1

 TERMINÉ 

Immune Functions of Myeloid Syk-coupled C-type Lectin Receptors Sensing Necrosis (CLR Sensing Necrosis)

Date du début: 1 déc. 2010, Date de fin: 31 août 2016,

Necrosis triggers an inflammatory response driven by macrophages that normally contributes to tissue repair but, under certain conditions, can induce a state of chronic inflammation that forms the basis of many diseases. In addition, dendritic cell (DC)-mediated presentation of antigens from necrotic cells can trigger adaptive immunity in infection-free situations, such as autoimmunity or therapy- ...
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 1

 TERMINÉ 

Caveolin-1 integrates stromal mechanical forces chemo-resitance to foster tumor progression (CAVCER)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2016,

Breast cancer affects 1 in 8 women and is the chief cause of female cancerdeaths in the EU. Early detection continues to improve survival, but prognosisworsens significantly after metastasis. Metastasis and chemoresistance are linkedphenomena, but the molecular basis is unknown. The evidence suggests a role forCaveolin1 (Cav1): i) Cav1 mediates biomechanical remodelling of the extracellularmatrix ...
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 1

 TERMINÉ 

Mitochondrial deficiency and cardiomyopathy. Role of Reactive Oxygen Species (ROLROS)

Date du début: 2 avr. 2012, Date de fin: 1 avr. 2016,

"Mitochondrial diseases are now considered to be among the most common forms of genetic disorders, with a minimum prevalence of 1 in 5000 individuals. They can be caused by mutations in either the nuclear or the mitochondrial DNA (mtDNA). One of the most well characterized clinical presentations is neuromuscular dysfunction, followed by cardiomyopathy, generally in the form of hypertrophic cardiom ...
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 1

 TERMINÉ 

Regulation of normal and leukaemic stem cells by the microenvironment: role of nestin+ mesenchymal stem cells and humoral signals (LSCMICROENV)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2016,

The presence of self-renewing “cancer stem cells” responsible for tumour initiation and maintenance has been well defined in multiple types of solid and haematologic tumours; however, our knowledge of their biology is very limited. While it is believed that leukaemia stem cells (LSC) – like normal haematopoietic stem cells (HSC) – depend on the interaction with a specialized microenvironment or ‘n ...
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 1

 TERMINÉ 

Translational Training network on the Cellular and Molecular Bases of Heart Homeostasis and Repair (CardioNeT)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

The CardioNeT Initial Training Network aims to implement a highly multidisciplinary, intersectoral and competitive training programme in cardiovascular research through cutting-edge projects and extensive training in complementary areas.CardioNeT training comprises two tightly linked components - research and complementary training - that will be implemented at local as well as network level and ...
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 13

 TERMINÉ 

Homeostatic regulation of mesenchymal stem cells in the haematopoietic stem-cell niche (MSC-HSC NICHE)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

The cells forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear. Our recent studies have demonstrated that mesenchymal stem cells (MSC) identified using expression of the intermediate filament protein nestin constitute an essential HSC niche component. Nestin+ cells contribute to bone formation, contain all the mesenchymal activity and can self-renew and expand in serial ...
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 1

 TERMINÉ 

Living Photonics: Monitoring light propagation through cells (LiPhos)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2015,

LIPHOS is focused on the development of completely innovative biophotonic diagnosis tools, which are for the first time implemented using cells as constituent material. Here, and unlike existing systems, light remains confined in a waveguide whose core is uniquely composed by cells, giving rise to the "Living photonics" concept. In this context, cells play a two-fold role: i) they form the biomate ...
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 8

 TERMINÉ 

CNIC INTERNATIONAL INCOMING FELLOWSHIPS FOR YOUNG GROUP LEADERS (CNIC IIF)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,

The CNIC IIF Programme will offer a total of 24 positions during the COFUND programme life (four years) in the incoming mobility type in the area of cardiovascular research.Every year six fellowships will be offered at the level of young group leaders: 4 Starting Fellowships (SF) and 2 Advanced Fellowships (AF). In both cases, the duration of the fellowships will be 3 years and have particular ob ...
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 1

 TERMINÉ 

Cardiac fibrosis versus regeneration: lessons learned from the zebrafish (CAREFISH)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2015,

Myocardial infarction (MI) leading to ischemic heart disease is the most common cause of death worldwide. In mammals, MI results in the in the replacement of the damaged myocardium with a scar. However, other animals, such as teleost fish have a remarkable capacity to regenerate damaged tissue replacing it with newly formed tissue. Recently, a zebrafish model of MI has been established. Cryoinjury ...
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 1

 TERMINÉ 

Oxygen sensing in cardiovascular progenitors cell fate decisions (Hypoxia & Cell Fate)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

Cardiogenesis is a complex process that involves different cell types that have to mature to form the final functional heart compartments. Isl1 cardiovascular progenitors label the “second heart field” and contribute to myocardial, smooth muscle and endothelial structures of the heart. These progenitors have been extensively studied but little is know about the extracellular signals mediating thei ...
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 1

 TERMINÉ 

Molecular mechanisms of mature B cell lymphomagenesis (BCLYM)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2014,

Most of the lymphomas diagnosed in the western world are originated from mature B cells. The hallmark of these malignancies is the presence of recurrent chromosome translocations that usually involve the immunoglobulin loci and a proto-oncogene. As a result of the translocation event the proto-oncogene becomes deregulated under the influence of immunoglobulin cis sequences thus playing an importan ...
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 2

 TERMINÉ 

Psychosocial Factors and Cardiovascular Disease in Spain (PSYCHO CARDIO SPAIN)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2014,

"The study of the possible associations of psychosocial factors as job strain, depression, social support and stress, with the development, treatment and prognosis of cardiovascular disease (CVD) is a promising research field. Job strain and depression are highly prevalent conditions, and CVD remains to be the first cause of death in most countries around the world. Nevertheless, only a few cardio ...
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 2

 TERMINÉ 

Fixed Dose Combination drugs for Secondary Cardiovascular Prevention (FOCUS)

Date du début: 1 juil. 2010, Date de fin: 30 juin 2014,

Cardiovascular diseases (CVD) are the leading cause of death worldwide, and their incidence is increasing sharply in developing countries. Two insufficiently addressed factors contribute to increased morbidity and mortality, threatening the effectiveness of any health system: poor patient adherence to treatment, and limited access to medication in resource-poor countries and regions. To address th ...
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 9

 TERMINÉ 

Role of c-Myc in atherosclerotic macrophages (MycMacs)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2014,

Atherosclerosis and associated cardiovascular disease are the leading causes of mortality in developed countries and the World Health Organization has estimated that by 2020 these disorders will be the main sanitary and socio-economic problem world-wide due in part to the progressive aging of our societies. Atherosclerosis is a complex chronic inflammatory process triggered and perpetuated by card ...
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 2

 TERMINÉ 

LEUKOCYTE MICRODOMAINS AND PLATELET INTERACTIONS IN THROMBO-INFLAMMATORY INJURY (LEMPIT)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2013,

"During the inflammatory response, leukocytes accumulate in the vascular lumen and undergo a morphological and molecular polarization characterized by the formation of discrete domains (a leading edge and an uropod) that allows their directional migration. We aim to understand how and when this polarization originates, as well as the endothelial signals that induce it under physiological condition ...
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 1

 TERMINÉ 

Contribution of RXRs to myeloid cell biology: from hematopoietic stem cells to osteoclastogenesis (RXR in myeloid cells)

Date du début: 1 sept. 2010, Date de fin: 31 août 2013,

Hematopoietic stem cells (HSCs) yield blood precursors devoted to unilineage differentiation and production of mature blood cells, including red blood cells, megakaryocytes, lymphocytes and myeloid cells. Precursors of the myeloid lineage differentiate into monocytes and granulocytes but at given stages of their maturity they can be also sources of multinucleated osteoclasts. Consequently, any alt ...
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 1

 TERMINÉ 

NOTCH SIGNALING IN DEVELOPMENT AND PATHOLOGY (NotchIT)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,

Eight partners from six different EU countries will converge in NotchIT, a multi-site ITN aimed to increase the knowledge of cellular and molecular mechanisms by which Notch signaling regulates the development and pathology of different tissues. Notch signaling plays a key role in cell-fate determination and differentiation of various cell types and aberrant Notch signaling is associated with path ...
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 11

 TERMINÉ 

Role of Calcineurin alternative splicing variant CnAbeta1 in stem cell biology and cardiac development (CARDEB1)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2012,

"The heart is the first organ to form and it is essential for blood distribution during embryogenesis. Congenital heart malformations are the most common birth defect in humans, present in 1 % of the human population worldwide. The calcineurin splicing variant CnAbeta1 is expressed in stem cells, precursors and developing tissues and its expression decreases during tissue maturation. We aim to det ...
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 1

 TERMINÉ 

Role of Meis1 in the embryonic megakaryocyte lineage and vascular development (Meis1 & Vascular MK)

Date du début: 1 juin 2010, Date de fin: 31 mai 2012,

The main aim of the present project is to provide the first description of embryonic megakaryocyte function during vascular development and maintenance. The recent description of embryonic megakaryocytes existence together with the presence of vascular defects in all mouse mutant models that lack embryonic megakaryocytes suggests that a cellular interaction between embryonic megakaryocytes and end ...
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 1

 TERMINÉ 

Hybrid PET-MR system for concurrent ultra-sensitive imaging (HYPERImage)

Date du début: 1 avr. 2008, Date de fin: 30 sept. 2011,

The HYPERImage project will develop a novel hybrid system for simultaneous whole-body PET/MR imaging for humans. It will advance the required Time-of-Flight (ToF) PET technology, and the software for MR mediated compensation of motion artefacts. The hybrid system will be validated in pre-clinical and initial clinical studies, for exemplary applications in cardiovascular diseases, and in breast can ...
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 8

 TERMINÉ 

Role of PPARgamma in the interstitial fluid volume regulation and contribution to cardiovascular complications of TZDs (PGFC)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2011,

"Thiazolidinediones (TZDs) are clinically proven insulin sensitizers with anti-inflammatory benefits used in the therapy of type 2 diabetes mellitus (T2DM) and atherosclerosis. TZDs can activate a transcription factor, the peroxisome proliferator-activated receptor gamma (PPARg). PPARg regulates expression of several genes involved in inflammatory pathways, lipid transport and carbohydrate metabol ...
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 1