3 projets européens trouvés
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TERMINÉ
Muscle Stress Relief: An integrated research program linking together basic research on secondary myopathies in stress states to innovative translation in applied myology. (Muscle stress relief)
Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,
A diverse variety of medical or lifestyle conditions lead to a progressive loss of muscle force by functionally impairing myofibril contractility and causing ultimately myofibril loss. Major underlying risk factors of chronic muscle force loss are ageing, inactive lifestyles, and unbalanced nutrition. Together, these factors are predicted to lead to an endemic incidence of muscle weakness both in ...
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14
Participants partenaires
TERMINÉ
DEFINING THE MECHANISMS OF AGE-RELATED MUSCLE LOSS: FOCUS ON AUTOPHAGY (MyoPHAGY)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2016,
Muscle loss occurs in many diseases including cancer, AIDS, diabetes, renal or cardiac failure and sepsis. The wasting of muscle mass is characterized by the activation of an atrophy program that coordinates the ubiquitin-proteasome and autophagy-lysosome systems. The simultaneous activation of these systems allows the breakdown of contractile proteins and the removal of organelles. Ageing sarcope ...
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1
Participant partenaire
TERMINÉ
Understanding and combating human age-related muscle weakness (MYOAGE)
Date du début: 1 janv. 2009, Date de fin: 30 juin 2013,
Ageing of skeletal muscle results in a progressive loss of mobility that decreases the quality of life and has major economic and social consequences for society at large. Increasing muscle weakness is a major component of muscle ageing. In the elderly muscles become atrophic (loss in muscle mass) and weaker (loss in muscle force), more susceptible to damage and consequently regenerate and recover ...
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