8 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Exploiting Glycosylation of Colorectal Cancer for the development of improved diagnostics and therapeutics (GlyCoCan)
Date du début: 1 sept. 2015, Date de fin: 31 août 2019,
Colorectal cancer (CRC) is a major worldwide cancer burden with about 1.4 million cases in 2012 and an annual mortality of approximately 700,000. Early detection is crucial as treatment is most efficient in early stages where population based screenings could substantially reduce incidence and mortality.Current screening techniques are invasive or lack sensitivity and specificity. Moreover, the mo ...
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9
Participants partenaires
TERMINÉ
Epithelial resistance modulation to treat disease (EMODI)
Date du début: 1 oct. 2016, Date de fin: 31 mars 2018,
Epithelial barriers are essential for organism’s homeostasis and survival. Defects in resistance of body barrier epithelial tissues and their repair are thought to underlie a range of diseases, which affect millions. Antonio Jacinto’s group has discovered that Septate/Tight Junctions are essential for epithelial repair. These cell-cell junctions can be potentially targeted by candidate compounds t ...
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1
Participant partenaire
TERMINÉ
Mechanisms of synaptic growth and plasticity (Neuronal Trafficking)
Date du début: 1 mars 2016, Date de fin: 28 févr. 2018,
My long-term goal is to understand the cellular and molecular mechanisms that govern synaptic growth and plasticity, and how dysfunction in these pathways contributes to disease. Neurons are the most morphologically diverse cell type whose morphology determines many functional aspects of a neuronal network. The primary shape of a neuron is established during axon and dendrite outgrowth and synapse ...
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1
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TERMINÉ
European Clinical Research Infrastructures Network - Integrating Activity (ECRIN-IA)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,
ECRIN is a distributed ESFRI-roadmap pan-European infrastructure designed to support multinational clinical research, making Europe a single area for clinical studies, taking advantage of its population size to access patients. Servicing multinational trials started during its preparatory phase, and it now applies for an ERIC status by 2011. The ERIC budget will be restricted to core activities re ...
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48
Participants partenaires
TERMINÉ
The molecular physiology and the evolution of a new pathway promoting developmental stability (FLY-PHY)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
Developmental stability is the ability of an organism to buffer given traits against environmental and intrinsic perturbations. This may involve physiological, temporal or behavioral adjustments to the developmental program. The processes leading to developmental stability have been particularly well studied in arthropods. For instance, if uncoordinated growth is induced in the larval imaginal dis ...
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1
Participant partenaire
TERMINÉ
The role of neuronal intracellular traffic in Alzheimer´s disease (TRAFFICINAD)
Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,
In neurons of Alzheimer’s disease (AD) there is an aberrant accumulation of beta-amyloid (Aβ) at synapses that renders difficult the formation of new memories for AD patients. Intracellular trafficking abnormalities have been implicated in Aβ accumulation. This research project aims to define how neuronal intracellular trafficking is mechanistically involved in Aβ accumulation that leads to AD. W ...
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1
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TERMINÉ
Role of Arl13b in endocytic trafficking (Arl13b trafficking)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,
To move cargo between specific membrane-bound intracellular compartments, eukaryotic cells have evolved numerous mechanisms of membrane trafficking regulation. We found that CD1a, an MHC Class I-like lipid antigen presenting molecule follows an endocytic recycling pathway similar to that used by MHC Class I and other cargo internalized independently of clathrin. In an attempt to discover new regul ...
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1
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TERMINÉ
Optimizing suicide prevention programs and their implementation in Europe (OSPI-Europe)
Date du début: 1 oct. 2008, Date de fin: 31 mars 2013,
Suicide is a serious public health problem in the EU calling for effective interventions. The aim of this project is to provide EU member states with an evidence based prevention concept, concrete materials and instruments for running and evaluating these interventions and recommendations for the proper implementation of the intervention. These aims will be achieved by the following objectives: &g ...
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