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LINE-1 retrotransposition in human somatic cells (SOMATIC_MOSAICISM)
Date du début: 12 juin 2013, Date de fin: 11 juin 2015,
The human genome is largely composed of non-coding DNA, only 3-5% codes for exons. The majority of the non-coding DNA is however fundamental for the correct functioning and regulation of the genome. Transposable elements (TEs) like LINEs generated up to 50% of the human genome during evolution. They can mobilize, causing mutations but also conferring genomic plasticity. The generation of new inser ...
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