5 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Towards clinical translation of new gene targeting technologies for correcting inherited mutations and empowering adoptive immunotherapy of cancer (SUPERSIST)
Date du début: 1 mai 2013, Date de fin: 31 oct. 2016,
Substantial evidence supports the therapeutic potential of ex vivo gene therapy based on Hematopoietic Stem Cell (HSC) or T lymphocytes to treat inherited diseases or cancer. Yet, the intrinsic limitations of current gene replacement approaches based on semi-randomly integrating vectors, and the occurrence in some clinical trials of severe adverse events related to gene transfer, prevent safe depl ...
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5
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TERMINÉ
Advanced Cell-based Therapies for the treatment of Primary ImmunoDeficiency (CELL-PID)
Date du début: 1 nov. 2010, Date de fin: 30 avr. 2016,
Primary immune deficiencies (PID) are inherited disorders of the adaptive and innate immune system marked by severe infections, autoimmunity and high risk of cancer. Treatment entails hematopoietic stem cell (HSC) transplantation from allogeneic donors, however in the absence of an HLA compatible donor, HSCT outcome is limited by delayed or suboptimal reconstitution and complications. SCID-X1 and ...
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20
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TERMINÉ
Optimization of stem cell therapy for clinical trials of degenerative skin and muscle diseases (OptiStem)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2013,
This proposal aims to develop and implement efficacy of clinical trials with adult, tissue stem cells for degenerative diseases of epithelia and skeletal muscle. Extraordinary progress in the understanding of several key features of stem cells has been rapidly translated into novel cell therapy protocols that have yielded positive results in pre-clinical models of genetic and acquired diseases and ...
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20
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TERMINÉ
Advanced Teaching and TRaining for Adoptive Cell Therapy (ATTRACT)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,
Considerable resources are devoted to fighting cancer throughout Europe, yet these efforts are not producing the results that health practitioners and citizens might expect. This is partly due to the fragmentation and duplication of research efforts within Member states and the lack of co-ordination at European level. However it can also be attributed to the need to retain and most importantly dev ...
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16
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TERMINÉ
Persisting Transgenesis (PERSIST)
Date du début: 1 janv. 2009, Date de fin: 30 juin 2013,
"For many disabling or fatal diseases, there is pre-clinical or clinical evidence of the potential therapeutic efficacy of gene therapy and, yet, the limitations of current gene transfer technologies have prevented success or even caused serious adverse events leading to termination of trials. PERSIST will explore the use of highly innovative gene-modifying and delivery technologies and capitalize ...
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