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11 projets européens trouvés

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 TERMINÉ 

QUantitative Imaging in Cancer: CONnecting CEllular Processes with Therapy (QUIC-CONCEPT)

Date du début: 1 sept. 2011, Date de fin: 31 déc. 2017,

The QuIC-ConCePT consortium has 2 objectives: 1.(90% of resource, WP2-5) to qualify 3 specific imaging biomarkers (IBs) of tumour cell proliferation, apoptosis, and necrosis, to allow drug developers to demonstrate reliably modulation of these pathologic processes in tumours in patients in realistic trials. Our vision for January 2016 is that drug developers can incorporate these IBs for decision- ...
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 26

 TERMINÉ 

Breast Cancer Somatic Genetics Study (BASIS)

Date du début: 1 juil. 2010, Date de fin: 31 déc. 2014,

"All cancers arise due to somatically acquired mutations in their genomes which alter the function of key cancer genes. Understanding these critical mutational events underlying cancer development is paramount for advancing prevention, early detection, monitoring and treatment of the disease. Breast cancer is the most common class of cancer diagnosed in women worldwide with more than one million c ...
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 16

 TERMINÉ 

Chromatin Mediators of Estrogen Receptor Biology (ER_Partners)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2014,

Estrogen Receptor (ER) drives proliferation in breast cancers and drugs such as tamoxifen and Aromatase Inhibitors, that target ER activity, are first line treatments in clinical practice. However drug resistance is a significant clinical problem. My laboratory has reported that chromatin-modifying pioneer factors are required for ER to bind the genome, and may constitute a unique opportunity for ...
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 2

 TERMINÉ 

Targeting the tumour microenvironment to improve pancreatic cancer prognosis (EPC-TM-Net)

Date du début: 1 févr. 2011, Date de fin: 31 juil. 2014,

...tic spread. Identification of cancer (stem) cell-autonomous as well as stromal-derived mediators of invasion and chemoresistance will lead to novel drug targets to overcome the current therapeutic dilemma. The consortium has been specifically designed to include all required levels of expertise: 1) surgical and medical oncology groups conducting the largest clinical trials for pancreatic cancer in ...
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 17

 TERMINÉ 

Gene Discovery in Melanoma Progression and Therapeutic Resistance (Melanoma Genes)

Date du début: 15 avr. 2012, Date de fin: 14 avr. 2014,

Melanoma is among the most common and deadly human cancers. It kills more than 2000 people in the UK every year but an effective cure for metastatic disease does not exist yet.The mutation of valine to glutamic acid at position 600 (V600E) of the BRAF kinase is found in over 60% of human melanomas, establishing it as a prominent oncogene in melanoma. Since this mutation is also commonly identified ...
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 2

 TERMINÉ 

Conservation and Divergence of Tissue-Specific Transcriptional Regulation (ConservRegCircuitry)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2013,

Vertebrates contain hundreds of different cell types which maintain phenotypic identity by a combination of epigenetic programming and genomic regulation. Systems biology approaches are now used in a number of laboratories to determine how transcription factors and chromatin marks pattern the human genome. Despite high conservation of the cellular and molecular function of many mammalian transcrip ...
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 2

 TERMINÉ 

New imaging methods for detecting treatment response in lymphoma (IMAGING LYMPHOMA)

Date du début: 1 mars 2010, Date de fin: 29 févr. 2012,

"Assessing treatment response in cancer is the most important single prognostic factor for a patient. Therefore, it is crucial to detect response as early as possible during treatment. Additionally, similar tumour types frequently have markedly different responses to the same therapy. Hodgkin lymphoma, for example, is one of the tumour types where a small group of patients fail to respond or respo ...
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 1

 TERMINÉ 

Pancreatic stellate cells - sentinels for tissue damage? (Pancreatic cancer)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2011,

Pancreatic ductal adenocarcinoma (PDA) is a lethal disease killing about 7000 people in the United Kingdom every year. PDA is resistant to conventional therapy. A hallmark of PDA is the abundance of desmoplastic stroma, which is thought to originate by activation of pancreatic stellate cells (PSC). Unfortunately, little is know about the precise role of PSC in the physiology of the pancreas. In th ...
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 1

 TERMINÉ 

A study of TGF-beta effects on breast cancer stem cells (TGF-beta and BCSCs)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2011,

A highly tumourigenic subpopulation of cancer cells has recently been identified in primary and metastastatic breast cancer. This minority of cells termed tumour-initiating cells or “cancer stem cells“ (CSC) has been shown in several solid tumours to bear stem cell features such as the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumour. Correlat ...
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 1

 TERMINÉ 

Functional tumour genomics using metabolomic profiling (FUTUGEMET)

Date du début: 1 mai 2009, Date de fin: 30 avr. 2011,

"Metabolite profiling, as demonstrated by the host laboratory, has the power to discriminate single gene alterations and to identify metabolite biomarkers that potentially can function as surrogates for the genetic event. In addition they have shown that pattern recognition within NMR-derived metabolome profiles from gene deletion mutants can be used as a functional genomics tool to confirm the id ...
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 1

 TERMINÉ 

Deciphering the role of chromatin in epidermal stem cell biology (CHROMATIN IN SKIN)

Date du début: 1 juin 2008, Date de fin: 31 mai 2010,

"The skin is a multi-layered epithelium consisting of interfollicular epidermis (IFE), hair follicles (HF), sebaceous glands (SG) and apocrine (sweat) glands. Continuous shedding of terminally differentiated keratinocytes necessitates constant regeneration to ensure tissue homeostasis. This depends on the epidermal stem cell compartment located on top of the basement membrane. Several of the signa ...
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 1