3 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
miR-483-3p and drug resistance in Hepatocarcinoma (VeromiRNA)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,
Hsa-mir-483 is located within intron 2 of the INS-IGF2 gene. We have previously shown oncogenic features of miR-483-3p targeting the pro-apoptotic gene BBC3/PUMA (P53 up-regulated modulator of apoptosis gene) giving drug resistance to cells. Generally the IGF2 and miR-483 expression are strictly correlated although we have demonstrated that expression of miR-483 can be induced independently of IGF ...
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TERMINÉ
The impact of the tissue microenvironment on the microRNAs in chronic lymphocytic leukemia (ViMiRNAsCLL)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,
Despite the advancement achieved in the treatment of Chronic Lymphocytic Leukemia (CLL), it remains an incurable disease. The current approach to handle CLL patients is “watch and wait” and the treatment starts when the disease is progressing. Therefore, one of the major challenges is to find genes responsible for the progression of the disease and discover the mechanisms that influence the expres ...
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TERMINÉ
Mechanisms of Inflammation Resolution: Role of miRNAs (ResolutiomiR)
Date du début: 1 sept. 2011, Date de fin: 31 août 2015,
The elucidation of endogenous pathways and chemical mediators that activate resolution of inflammation is crucial to identify new therapeutic approaches to control excessive inflammation and related diseases. Inflammation and resolution are actively regulated processes, during which a temporal switch in leukocyte populations present in the exudates occurs, likely reflecting changes in bone marrow ...
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