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Our ability to think, to memorize and focus our thoughts depends on acetylcholine signaling in the brain. The loss of cholinergic signalling in for instance Alzheimer’s disease strongly compromises these cognitive abilities. The traditional view on the role of cholinergic input to the neocortex is that slowly changing levels of extracellular acetylcholine (ACh) mediate different arousal states. Th ...

The land and oceans have mitigated climate change by taking up about half of the anthropogenic CO2 emitted since the industrial revolution. However, these ‘sinks’ are predicted to lose their efficiency. Globally, the combined sink strength of the land and ocean can be calculated indirectly as the difference between anthropogenic emissions – from fossil fuel burning and deforestation – and the atmo ...