11 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
The quantitative Bcl-2 interactome in apoptosis: decoding how cancer cells escape death (APOQUANT)
Date du début: 1 avr. 2013, Date de fin: 31 mars 2019,
The proteins of the Bcl-2 family function as key regulators of apoptosis by controlling the permeabilization of the mitochondrial outer membrane. They form an intricate, fine-tuned interaction network which is altered in cancer cells to avoid cell death. Currently, we do not understand how signaling within this network, which combines events in cytosol and membranes, is orchestrated to decide the ...
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TERMINÉ
EXtreme Tectonics and Rapid Erosion in Mountain Environments (EXTREME)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,
"Tectonic plate corners are hotspots for high rates of continental deformation and erosion, and associated with human-relevant hazards including poorly understood earthquakes, destructive landslides, and extreme climate. A better understanding of continental deformation can mitigate these hazards. However, the coupling between climate and tectonic interactions at plate corners is a key unknown and ...
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TERMINÉ
Designing microProteins to alter growth processes in crop plants (miPDesign)
Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,
The directed control of protein activity plays a crucial role in the regulation of growth and development of multicellular organisms. Different post-translational control mechanisms are known to influence the activity of proteins. Here, I am proposing a novel way to control the activity of proteins that function as multimeric complexes. MicroProteins, are small single-domain protein species that c ...
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2
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TERMINÉ
Ancient Pathogen Genomics of Re-Emerging Infectious Disease (APGREID)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
Here we propose a first step toward a direct reconstruction of the evolutionary history of human infectious disease agents by obtaining genome wide data of historic pathogens. Through an extensive screening of skeletal collections from well-characterized catastrophe, or emergency, mass burials we plan to detect and sequence pathogen DNA from various historic pandemics spanning at least 2,500 years ...
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2
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TERMINÉ
Microbial formation of minerals by communities of Fe(II)-oxidizing bacteria in modern and ancient environments (MICROFOX)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
"Iron minerals are ubiquitously present in the environment. Their formation is linked to the global C and N cycle and they control the fate of nutrients, metals, and greenhouse gases. My recent work, published in international journals including Nature Geoscience, showed that Fe(II)-oxidizing bacteria form Fe(III) minerals and suggested that such bacteria were involved in the deposition of Precamb ...
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TERMINÉ
Paleoanthropology at the Gates of Europe: Human Evolution in the Southern Balkans (PaGE)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,
Despite long study, European paleoanthropology is still hotly debated and continues to produce unexpected and surprising findings. Such discoveries have radically changed our ideas about human presence in Europe: The former view of Europe as inhospitable to humans until 500 thousand years before present (ka) is now challenged by new evidence indicating colonization at just over one million years a ...
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1
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TERMINÉ
Protein Friction of Molecular Machines: Nanomechanics with Optical Tweezers (NANOMECH)
Date du début: 1 déc. 2010, Date de fin: 30 nov. 2015,
Molecular machines---assemblies of macromolecules, often fueled by nucleotide hydrolysis---are fascinating devices and crucial for driving self-organization in cells. While protein components of many biological machines have been identified, and in many cases their structures have been solved, the mechanical principles that govern the operation of biological machines are poorly understood. For exa ...
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2
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TERMINÉ
Non-classical interacting random walks (NCIRW)
Date du début: 1 oct. 2008, Date de fin: 30 sept. 2014,
"The proposed project deals with various topics in the area of random walks (RWs) which interact with their own history and/or a possibly non-homogeneous, random environment. Such models arise from physics and other natural sciences as simplified models of complex phenomena and have recently attracted a lot of attention. They include: (a) Self-interacting RWs, i.e. RWs with memory, for example exc ...
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TERMINÉ
Analysis of evolutionary conserved signalling pathways mediating polar leaf development in dicotyledonous plants (EvoSignal)
Date du début: 1 juin 2010, Date de fin: 31 mai 2014,
Like all seed plants, the body of the model plant Arabidopsis thaliana consists of two distinct systems, the root and the shoot. The shoot system contains the shoot apical meristem (SAM) harboring a population of plant stem cells. During the vegetative growth phase the population of stem cells in the SAM divides asymmetrically and produces the cells that will eventually form new organs. Leaves are ...
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1
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TERMINÉ
Solid State/Cold Atom Hybrid Quantum Devices (Socathes)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2013,
Solid state physics and atomic physics have developed in a way that the combination of the two fields will produce massive synergetic effects and new physics. Thin film structures can be patterned and controlled down to the atomic level. Mesoscopic structures are used to create well defined two level systems and are presently explored in terms of their capability of being the basis of a quantum co ...
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TERMINÉ
"Governance of Educational Trajectories in Europe. Access, coping and relevance of education for young people in European knowledge societies in comparative perspective" (GOETE)
Date du début: 1 janv. 2010, Date de fin: 31 mars 2013,
"The GOETE project will analyse the role of school in re-conceptualising education in terms of lifelong learning by combining a life course and a governance perspective. In European knowledge societies adequacy of education means a balance of individual, social and economic aspects. This is operationalised by exploring how educational institutions conceptualise and organise individual educational ...
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