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Effects of systemic annonacin exposure in transgenic mice expressing normal or mutant human tau protein: role of environment-gene interactions in neuro- degeneration (TAU-ANNONACIN)
Date du début: 1 mai 2009, Date de fin: 30 avr. 2010,
Experimental and epidemiological studies have identified natural substances, such as the acetogenin annonacin, that could be associated with mechanisms of neurodegeneration in some forms of tauopathies. Many mutations in the taugene have also been associated with familial cases of tauopathies, such as the frontotemporal dementias with parkinsonism linked to chromosome 17 (FTDP-17). However, it is ...
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