13 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century (EU-ToxRisk)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2021,
The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemi ...
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43
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TERMINÉ
Muscle Stress Relief: An integrated research program linking together basic research on secondary myopathies in stress states to innovative translation in applied myology. (Muscle stress relief)
Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,
...ires a multidisciplinary approach covering aspects of ageing, metabolism, and on the humoral cross-talk of muscle with other key organs including heart, liver, kidney, and lung. To achieve this, six European groups with complementary expertise in inter-organ-cross-talk during stress-induced secondary myopathies will team-up with a leading team in the U.S. with expertise in the translation of musc ...
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14
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TERMINÉ
Statistical multi-Omics UNDerstanding of Patient Samples (SOUND)
Date du début: 1 sept. 2015, Date de fin: 31 août 2018,
Bioinformatic analysis is the biggest bottleneck in many genomic medicine projects. Our objective is to enable researchers to dramatically increase statistically informed use of personal multi-omic data in medicine. Soon, multiple types of omic technologies will be applied to 100,000s of patient-derived samples, with the three-stage goal of better understanding disease biology, discovery of new in ...
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11
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TERMINÉ
Early warning signals of ageing in human stem cells and age-related disorders (SYSTEMAGE)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
The regenerative power of a living organism is linked to the potential of its stem cells to replace the corresponding damaged tissue. Therefore organisms are as old as their stem cells. Whereas the vulnerability to cancer and chronic inflammation is associated with a decline of the immune system, the latter is in turn a sum product of interactions among hematopoietic stem cells (HSC), endothelial ...
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11
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TERMINÉ
Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine (NCRNAPAIN)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs (ncRNAs) regulate both immune and neuronal processes. Therefore, ncRNAPain proposes that ncRNAs are critically important master switches for chronic pain.ncRNAPain represents a multidisciplinary consortium of clinical partners, molecular and systems-level n ...
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12
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TERMINÉ
Peroxisomes: key to cell performance and health (PERFUME)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,
The PERFUME (PERoxisome Formation, Function, MEtabolism) program is an interdisciplinary and intersectoral ITN providing state-of-the-art research training at the interface of medicine, plant and fungal biology. The PERFUME S&T specifically aims at unraveling the principles of peroxisome biology.Peroxisomes have been discovered relatively recently (in 1954). Consequently, the level of understandin ...
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12
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TERMINÉ
Infrastructure for Systems Biology - Europe (ISBE)
Date du début: 1 août 2012, Date de fin: 31 juil. 2015,
The Infrastructure for Systems Biology in Europe (ISBE) programme comprises an infrastructure that is designed to meet the needs of European systems biology, in terms of development, applications and training. In order to address this requirement, we are proposing a distributed, interconnected infrastructure which primarily comprises three types of centres: Data Integration Centres (DICs), and sys ...
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24
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TERMINÉ
A systems biology approach to dissect cilia function and its disruption in human genetic disease (SYSCILIA)
Date du début: 1 juin 2010, Date de fin: 31 mai 2015,
AIM: To identify the molecular mechanisms characterizing cilium function, and the discrete perturbations associated with dysfunction caused by mutations in inherited ciliopathies, applying a systems biology approach. BACKGROUND: Cilia are microtubule-based, centriole-derived projections from the cell surface. They transduce extracellular signals and regulate key processes in which signals of the e ...
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17
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TERMINÉ
Towards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR) (EVIMalaR)
Date du début: 1 oct. 2009, Date de fin: 31 mars 2015,
This is a proposal from 55 partners from 36 institutes to form a NoE that will seek to integrate European malaria research that is directed towards a better understanding of the basic biology of the parasite, its vector and of the biology of the interactions between the parasite and both its mammalian host and vectors. All the member institutes and researchers have demonstrated both their excellen ...
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40
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TERMINÉ
Euro-BioImaging - Research infrastructure for imaging technologies in biological and biomedical sciences (Euro-BioImaging)
Date du début: 1 déc. 2010, Date de fin: 31 mai 2014,
...e human organism. Euro-BioImaging will therefore develop a plan to construct and operate a set of complementary and strongly interlinked infrastructure facilities appropriately distributed across the European member states. To achieve this, Euro-BioImaging will define the legal and governance framework with its currently 22 member states and develop a finance plan in close cooperation with nationa ...
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44
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TERMINÉ
Research capacity for the implementation of genetic control of mosquitoes (INFRAVEC)
Date du début: 1 sept. 2009, Date de fin: 28 févr. 2014,
...f mosquito vectors. INFRAVEC aims at bridging the gap between the recent advances in transgenic technology and its implementation as a novel powerful approach for vector control. To this aim, a large European Infrastructure will be established, in which the coordination of efforts, expertise and facilities provided by the individual research groups and institutions will bolster and considerably ex ...
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31
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TERMINÉ
Cis-regulatory logic of the transcriptional control in neural stem cells (CISSTEM)
Date du début: 1 oct. 2008, Date de fin: 31 mars 2012,
"Neural stem cells (NSCs) have emerged as a major topic in neurobiology. The persistence of multipotent cells in the adult mammalian brain offers a realistic chance for the treatment of neurodegenerative diseases. It is thus crucial to understand NSCs from as many as possible angles (e. g. cellular and molecular biology), in order to better isolate and successfully manipulate them. CISSTEM present ...
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9
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TERMINÉ
Genomic screens to identify and characterize mechanisms of mycobacterial killing by Macrophages (MACROPHAGE GENOMICS)
Date du début: 1 oct. 2007, Date de fin: 30 sept. 2009,
Non-pathogenic mycobacteria are efficiently phagocytosed by macrophages and killed within phagosomes by acid hydrolases, reactive nitrogen intermediates, and likely other still unidentified factors that are part of the macrophage pro-inflammatory response. In contrast, pathogenic mycobacteria such as M. tuberculosis survive and grow within phagosomes by blocking macrophage pro-inflammatory respons ...
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