8 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
ORTHOpedic randomized clinical trial with expanded bone marrow MSC and bioceramics versus autograft in long bone nonUNIONs (ORTHOUNION)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
Current orthopaedic treatments permit spontaneous bone regeneration to unite and heal 90% bone injuries. Non-union associates pain and disability, often requiring biological enhancement. Regenerative medicine research suggests to the general public that alternative treatments based on advanced therapy medicinal products (ATMP) are already available. However, early clinical trials only explore its ...
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13
Participants partenaires
TERMINÉ
REgenerative Stem cell therapy for STroke in Europe (RESSTORE)
Date du début: 1 sept. 2015, Date de fin: 31 août 2020,
Stroke is the second leading cause of death in the world population. When not fatal, stroke often results in disability, due to motor and cognitive impairments, and secondary health problems affecting not only patients but also their families. Building on emerging preclinical and pilot clinical evidences, RESSTORE will focus on the clinical assessment of regenerative cell therapy to improve stroke ...
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29
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TERMINÉ
BIOactive implantable CApsule for PANcreatic islets immunosuppression free therapy (BIOCAPAN)
Date du début: 1 juin 2015, Date de fin: 31 mai 2019,
The key therapeutic issue in diabetes mellitus type I and II is glycaemic control. Reductions of constant self-control, of insulin injections, and of long-term complications would have tremendous benefit for quality of life. The best therapy option is the transplantation of allogeneic islet cells, but the current state of the art limits the applicability of this approach. Implanting unprotected gr ...
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10
Participants partenaires
TERMINÉ
Clinical trial of autologous adipose-derived mesenchymal stromal cells (ASC) in the treatment of mild to moderate osteoarthritis (ADIPOA2)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,
Osteoarthritis (OA) is an incurable disease that has evaded pharmacological interference, biologic therapy or surgical intervention to prevent disease progression. Currently, OA is designated the 11th highest contributor (of 291 diseases) of global disability. In the absence of effective treatment options, cellular therapies using mesenchymal stem/stromal cells (MSCs) have emerged as potential can ...
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20
Participants partenaires
TERMINÉ
Emergency evaluation of convalescent blood and plasma for Ebola Viral Disease (EVD) in affected West African countries. (Ebola_Tx)
Date du début: 1 nov. 2014, Date de fin: 31 oct. 2016,
The objective of this proposal is to urgently determine the efficacy, safety and feasibility of convalescent whole blood (CWB) and convalescent plasma (CP) therapy, as a treatment for patients with Ebola Viral Disease (EVD) to reduce the case fatality rate in the present EVD epidemic in West Africa. The trial will take place in three consecutive phases; i) initial phase to initiate harmonized stan ...
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8
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TERMINÉ
Regenerating Bone defects using New biomedical Engineering approaches (REBORNE)
Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,
Bone is among the most frequently transplanted tissue with about 1 million procedures annually in Europe. The worldwide market of bone replacement materials is currently estimated at 5 billion € with a 10% annual growth. Despite their considerable disadvantages, including the risk of disease transfer and immunologic rejection, limited supply of bone, costs and complications, allografts and autogra ...
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24
Participants partenaires
TERMINÉ
ADIPOSE DERIVED STROMAL CELLS FOR OSTEOARTHRITIS (ADIPOA)
Date du début: 1 janv. 2010, Date de fin: 30 juin 2014,
Osteoarthritis (OA) is a degenerative joint disease for which no efficient therapy is available. The ADIPOA consortium has previously shown that intraarticular injections of stromal cells prevents OA in two different models, but the mechanisms of this chondroprotective effect remains unknown, and the activation of cartilage derived endogenous stem cells is suspected. The participants have experien ...
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12
Participants partenaires
TERMINÉ
Cultivated Adult Stem Cells as Alternative for Damaged tissue (CASCADE)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2011,
"Rapid progress in stem cell research pave the way for the development and use of new cell therapy products in regenerative medicine. The objective of CASCADE is to provide the European Community with unique expertise which focuses on the GMP production of mesenchymal stem cells (MSC) and their use in treating skin and corneal wounds, so that quality and safety criteria are paramount and match the ...
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