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Plus de 40 projets européens trouvés

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 TERMINÉ 

Computational Design of Novel Functional Proteins for Immunoengineering (DeNovoImmunoDesign)

Date du début: 1 mars 2017, Date de fin: 28 févr. 2022,

Finely orchestrated protein activities are at the heart of the most fundamental cellular processes. The rational and structure-based design of novel functional proteins holds the promise to revolutionize many important aspects in biology, medicine and biotechnology. Computational protein design has led the way on rational protein engineering, however many of these designed proteins were solely foc ...
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 1

 TERMINÉ 

Connecting Statistical Mechanics and Conformal Field Theory: an Ising Model Perspective (CONSTAMIS)

Date du début: 1 mars 2017, Date de fin: 28 févr. 2022,

The developments of Statistical Mechanics and Quantum Field Theory are among the major achievements of the 20th century's science. During the second half of the century, these two subjects started to converge. In two dimensions, this resulted in a most remarkable chapter of mathematical physics: Conformal Field Theory (CFT) reveals deep structures allowing for extremely precise investigations, mak ...
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 1

 TERMINÉ 

MicroRobotic toolkit to deliver spatiotemporally resolved physicochemical signals and control cell sociology (ROBOCHIP)

Date du début: 1 mars 2017, Date de fin: 28 févr. 2022,

Biological organisms have spectacular three-dimensional morphologies in which correct multiscale organization and physicochemical regulation are essential for proper function. Understanding the dynamic interactions among cells connected through a structurally complex three-dimensional (3D) fibre network requires a rigorous system identification effort and engineering analysis. To develop accurate ...
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 1

 TERMINÉ 

Devices, engines and circuits: quantum engineering with cold atoms (DECCA)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2022,

Over the last decade, cold atomic gases have become one of the best controlled quantum system. This novel, synthetic material can be shaped at the microscopic level to mimic a wide range of models, and simulate the universal physics that these models describe. This project pioneers a new approach to quantum simulations, jumping from cold atoms materials into the realm of devices: systems carved ou ...
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 1

 TERMINÉ 

Miniature beam-driven Plasma ACcelerators (M-PAC)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

As we push the frontier of particle physics to higher particle energies, conventional accelerator techniques are attaining their limits and new concepts are emerging. The use of an ionized gas —or plasma— circumvents the most significant barrier of conventional techniques by increasing the energy gained per unit length by several orders of magnitude. One class of plasma accelerators, relevant for ...
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 1

 TERMINÉ 

Transposable elements, their controllers and the genesis of human-specific transcriptional networks (TRANSPOS-X)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Transposable elements (TEs) account for more than two thirds of the human genome. They can inactivate genes, provide novel coding functions, sprinkle chromosomes with recombination-prone repetitive sequences, and modulate cellular gene expression through a wide variety of transcriptional and posttranscriptional influences. As a consequence, TEs are considered as essential motors of evolution yet t ...
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 1

 TERMINÉ 

Multifunctional Hybrid Platforms based on Colloidal Nanocrystals to Advance CO2 Conversion Studies (HY-CAT)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

In reimagining the world’s energy future, while researchers are seeking alternative ways to produce energy, our current dependence on fossil fuels requires us to capture and store the CO2 to prevent reaching unacceptable CO2 levels in the atmosphere. In this scenario, recycling CO2 by converting it into useful chemicals, such as fuels for transportation, represents an important research area as it ...
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 1

 TERMINÉ 

High-throughput vibrational fingerprinting by nanoplasmonics for disease biology (VIBRANT-BIO)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Devastating diseases such as Alzheimer’s, Parkinson’s and various cancers are still without cures, continue to undermine the quality of life for millions of people and impose significant economic burdens. Misfolded toxic proteins constitute the microscopic basis of these diseases, but little is understood about their structure and biological function. This is due the fact that current technologies ...
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 1

 TERMINÉ 

New CHallenges for (adaptive) PDE solvers: the interplay of ANalysis and GEometry (CHANGE)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

The simulation of Partial Differential Equations (PDEs) is an indispensable tool for innovation in science and technology.Computer-based simulation of PDEs approximates unknowns defined on a geometrical entity such as the computational domain with all of its properties. Mainly due to historical reasons, geometric design and numerical methods for PDEs have been developed independently, resulting i ...
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 4

 TERMINÉ 

From Fermi to Planck : a bottom up approach (NuBSM)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

The Standard Model of particle physics is a hugely successful theory that has been tested in experiments at ever increasing energies, culminating in the recent discovery of the Higgs boson. Nevertheless, some major riddles cannot be addressed by the Standard Model, such as neutrino oscillations, the existence of Dark Matter, the absence of antimatter in the Universe. New fundamental principles, in ...
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 3

 TERMINÉ 

Charge carrier dynamics in metal oxides (DYNAMOX)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

Transition metal (TM) oxides (TiO2, ZnO, NiO) are large gap insulators that have emerged as highly attractive materials over the past two decades for applications in photocatalysis, solar energy conversion, etc., all of which rely on the generation of charge carriers, their evolution and their eventual trapping at defects or a self-trapped excitons. Despite the huge interest for such materials, th ...
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 1

 TERMINÉ 

Global integrative framework for Computational Bio-Imaging (GlobalBioIm)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

A powerful strategy for increasing the quality and resolution of medical and biological images is to acquire larger quantities of data (Fourier samples for MRI, projections for X-ray imaging) and to jointly reconstruct the complete signal by correctly reallocating the measurements in 3D space/time and integrating all the information available. The underlying image sequence is reconstructed globall ...
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 1

 TERMINÉ 

Building tomorrow’s nanofactory (NANOFACTORY)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

The aim of this project is to translate the concept of production line to the nanoworld to develop what could become tomorrow’s nanofactory. So far, nanostructures are either chemically synthesized or produced using top-down approaches such as nanolithography, but no processes exist to take a few nanostructures and perform the basic operations required to assemble them into a more complex system. ...
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 1

 TERMINÉ 

Unraveling molecular quantum dynamics with accelerated ab initio algorithms (MOLEQULE)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

Many physical and chemical processes in nature as well as an increasing number of man-made devices exploit the quantum properties of electrons, nuclei, and the quantum signatures of the coupling between nuclear and electronic motions. To optimize the design of novel devices and to correctly interpret physical processes studied, e.g., by experiments probing the molecular dynamics induced by interac ...
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 1

 TERMINÉ 

Hybrid Aircraft; academic reSearch on Thermal and Electrical Components and Systems (HASTECS)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

The HASTECS project aims at supporting the demonstration of radical aircraft configurations (CS-2/WP1.6) by means of models and tools development that can help the designers in assessing main benefits of architectures and power management of hybrid electric propulsion. The proposed consortium involves all competences to face the huge complexity of this process. All academic researchers will gather ...
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 3

 TERMINÉ 

Targeting common oncogenes with intracellular monobodies (ONCOINTRABODY)

Date du début: 1 août 2016, Date de fin: 31 juil. 2021,

Oncogenic signalling networks display a remarkable degree of plasticity. Despite only a limited number of alterations in oncogenes and tumour suppressor genes in most tumours, the majority of targeted therapeutics (monoclonal antibodies and small-molecule kinase inhibitors) does not strongly improve the survival of cancer patients and suffers from the rapid development of resistance. The rising nu ...
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 1

 TERMINÉ 

Valley and spin devices based on two-dimensional semiconductors (Valleys)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

The main objective of this research proposal is to realize new types of electronic devices based on the valley/spin degree of freedom in two-dimensional semiconductors from the transition metal dichalcogenide family. These materials are analogous to graphene but have a direct band gap. Together with the unique band structure, this allows manipulating the spin and valley degrees of freedom intercha ...
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 1

 TERMINÉ 

Fundamentals and Applications of Inorganic Oxygen Evolution Catalysts (FANOEC)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

The oxygen evolution reaction (OER) is the key reaction to enable the storage of solar energy in the form of hydrogen fuel through water splitting. Efficient, Earth-abundant, and robust OER catalysts are required for a large-scale and cost-effective production of solar hydrogen. While OER catalysts based on metal oxides exhibit promising activity and stability, their rational design and developmen ...
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 1

 TERMINÉ 

Mechanisms of recovery after severe spinal cord injury (HOW2WALKAGAIN)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

Severe spinal cord injury leads to a range of disabilities, including permanent motor impairments that seriously diminish the patients’ quality of life. In the framework of an ERC Starting Grant, my team and I developed a pragmatic therapy that restored supraspinal control of leg movement after complete paralysis in rats. However, the mechanisms underlying the effects of this intervention remain u ...
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 1

 TERMINÉ 

Milli-Volt Switch Technologies for Energy Efficient Computation and Sensing (Milli-Tech)

Date du début: 1 juin 2016, Date de fin: 31 mai 2021,

The Milli-Tech proposal aims at a novel technology platform serving both computation and sensing: electronic switch architectures, called steep slope switches, exploiting new device physics and concepts in emerging 2D materials to achieve operation at voltages below 100 millivolts. Such switches will have a subthreshold slope below 10mV/decade, significantly more abrupt than MOSFET thermal limit o ...
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 1

 TERMINÉ 

Cellular and molecular mechanisms of remote fear attenuation (Remote memory traces)

Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,

Traumatic events generate some of the most enduring forms of memories. Despite an elevated lifetime prevalence of related fear and anxiety disorders, effective treatments for traumatic memories are scarce and the mechanisms behind successful memory attenuation poorly understood. This discrepancy is particularly pronounced for remote traumata, when the original insult occurred in the distant past.H ...
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 1

 TERMINÉ 

Decoding, Mapping and Designing the Structural Complexity of Hydrogen-Bond Networks: from Water to Proteins to Polymers (HBMAP)

Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,

Hydrogen bonds are ubiquitous and fundamental in nature, underpinning the behavior of systems as different as water, proteins and polymers. Much of this flexibility derives from their propensity to form complex topological networks, which can be strong enough to hold Kevlar together, or sufficiently labile to enable reversible structural transitions in allosteric proteins. Simulations must treat t ...
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 1

 TERMINÉ 

III-Nitrides Nanostructures for Energy-Efficiency Devices (In-Need)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

Energy efficiency offers a vast and low-cost resource to address future energy demand while reducing carbon dioxide emissions. The unique properties of III-Nitride semiconductors make them the ideal material for future energy challenges. Their outstanding optical properties are revolutionizing the world with efficient LED light bulbs. Even greater impact is anticipated for power electronics. The m ...
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 1

 TERMINÉ 

Solid-state flow as a novel approach for the fabrication of photonic devices (FLOWTONICS)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

The development of advanced photon-based technologies offers exciting promises in fields of crucial importance for the development of sustainable societies such as energy and food management, security and health care. Innovative photonic devices will however reveal their true potential if we can deploy their functionalities not only on rigid wafers, but also over large-area, flexible and stretchab ...
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 1

 TERMINÉ 

Innovative Nanowire DEvicE Design (INDEED)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2021,

Nanowires (NWs) exhibit unique properties that make them potential building blocks for a variety of next generation NanoElectronics devices. Recent advances have shown that NWs with predefined properties can be grown, offering a new paradigm enabling functional device prototypes including: biosensors, solar cells, transistors, quantum light sources and lasers. The critical mass of scientific knowl ...
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 12

 TERMINÉ 

Laser Lightning Rod (LLR)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Controlling lightning is a long time dream of mankind. The goal of the present project is to investigate and develop a new type of lightning protection based on the use of upward lightning discharges initiated through a high repetition rate multi terawatt laser. The feasibility of the novel technique and the project’s prospect of success are based on recent research providing new insights into the ...
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 9

 TERMINÉ 

Ultrasensitive chiral detection by signal-reversing cavity polarimetry: applications to in-situ proteomics, single-molecule chirality, HPLC analysis, medical diagnostics, and atmospheric studies (ULTRACHIRAL)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Chirality is a fundamental property of life, making chiral sensing and analysis crucial to numerous scientific subfields of biology, chemistry, and medicine, and to the pharmaceutical, chemical, cosmetic, and food industries, constituting a market of 10s of billion €, and growing.Despite the tremendous importance of chiral sensing, its application remains very limited, as chiroptical signals are t ...
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 8

 TERMINÉ 

Integrated Sensing Architectures and Tools for Health Care (CyberCare)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

This proposal addresses high-risk, high-reward research of integrated sensing and computing architectures, as well as of models, methods and tools for their design and operation. Such architectures provide the bridge between bio-systems and information processing systems, where a bio-system is an abstraction of a human in terms of biophysical parameters. Breakthroughs in data acquisition, processi ...
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 1

 TERMINÉ 

INtestinal Tissue ENgineering Solution (INTENS)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Short Bowel Syndrome (SBS) is a condition that occurs when part or the entire small intestine is missing or has been removed during surgery. This condition renders the bowel incapable of fulfilling its nutritional function (intestinal failure). There is no cure for SBS. Parenteral (intravenous) nutrition (PN) and bowel transplantation are currently the preferred options for nutrition in children a ...
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 9

 TERMINÉ 

An Artificial Leaf: a photo-electro-catalytic cell from earth-abundant materials for sustainable solar production of CO2-based chemicals and fuels (A-LEAF)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

A novel concept for a photo-electro-catalytic (PEC) cell able to directly convert water and CO2 into fuels and chemicals (CO2 reduction) and oxygen (water oxidation) using exclusively solar energy will be designed, built, validated, and optimized. The cell will be constructed from cheap multifunction photo-electrodes able to transform sun irradiation into an electrochemical potential difference (e ...
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 15

 TERMINÉ 

Smart mitigation of flow-induced acoustic radiation and transmission for reduced aircraft, surface transport, workplaces and wind energy noise (SmartAnswer)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

A step change in our noise mitigation strategies is required in order to meet the environmental targets set for a number of sectors of activity affecting people through noise exposure. Besides being a hindrance to our daily life and subject to regulations, noise emission is also a competitive issue in today’s global market. To address these issues, new technologies have been emerging recently, bas ...
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 13

 TERMINÉ 

Hybrid Optomechanical Technologies (HOT)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The hybrid optomechanical technologies (HOT) consortium will lay the foundation for a new generation of devices, which connect, or indeed contain, several platforms at the nanoscale in a single “hybrid” system. As hybrid interfaces they will allow to harness the unique advantages of each subsystem within a nano-scale footprint, while as integrated hybrid devices they will enable entirely novel fun ...
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 17

 TERMINÉ 

Synaptic dysfunction in Neurodegenerative Diseases (SYNDEGEN)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Neurodegenerative diseases (NDDs) of aging are a growing burden on societies. Although studies on the degeneration of neurons have been a main focus of research, increasing evidence points to synapses as the site where Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD) begin. There is growing evidence that synapses are sites of early and aberrant protein misfolding, a ...
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 8

 TERMINÉ 

The Materials Genome in Action (MaGic)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,

It is now possible to make an enormous spectrum of different, novel nanoporous materials simply by changing the building blocks in the synthesis of Metal Organic Frameworks (MOF) or related materials. This unique chemical tunability allows us to tailor-make materials that are optimal for a given application. The promise of finding just the right material seems remote however: because of practical ...
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 1

 TERMINÉ 

Fibre Nervous Sensing Systems (FINESSE)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,

The unprecedented properties of optical fibres make them ideal to be implemented as 'artificial nervous systems', enabling any tool or structure to become a sensitive and smart object. Conventional optical fibres are small, low-cost and can be seamlessly integrated in materials, in engineering structures and in the environment. By exploiting the most advanced light-matter interactions, these tiny ...
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 10

 TERMINÉ 

Predictive and Accelerated Metabolic Engineering Network (PAcMEN)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,

The world economy is dependent on fossil resources: oil, gas and coal. The fossil resources are finite and their consumption causes catastrophic environmental changes. Therefore we need to move towards sustainable economy using renewable resources for energy and chemicals production. Via metabolic engineering approach, novel microbial cells can be created that can convert biomass and waste into fu ...
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 7

 TERMINÉ 

Multimodal, Functional Bio-Photonic Imaging (FBI)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,

FBI fosters education of ESRs on an emerging, multimodal imaging platform and its translation into clinical and biological applications. In FBI, 15 ESRs are trained at world-leading European academic institutions and companies, thus forming strong interdisciplinary relations between industry, technical sciences and clinical end-users.Optical imaging has huge potential to address unmet clinical nee ...
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 10

 TERMINÉ 

An e-infrastructure for software, training and consultancy in simulation and modelling (E-CAM)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2020,

E-CAM will create, develop and sustain a European infrastructure for computational science applied to simulation and modelling of materials and of biological processes of industrial and societal importance. Building on the already significant network of 15 CECAM centres across Europe and the PRACE initiative, it will create a distributed, sustainable centre for simulation and modelling at and acro ...
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 18

 TERMINÉ 

OMT - Optomechanical Technologies (OMT)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,

The proposed project is built on the successful training and research experience of the leading European research groups working in the field of cavity optomechanics. Our ENT unites a total of 14 leading groups in the field, of which two are major industrial players that utilize MEMS and NEMS - Bosch and IBM. The main goal of the project is to exploit optomechanical interactions in views of novel ...
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 14

 TERMINÉ 

Photo Induced Collective Properties of Hybrid Halide Perovskites (PICOPROP)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

The recent discovery of the organo-inorganic perovskite CH3NH3PbI3 as very efficient material in photoelectric conversion is multifaceted: it turns out that this compound is promising not only in photovoltaics, but it is lasing, it gives bright light emitting diodes, promising in water splitting and we are persuaded that it can play an important role in basic sciences, as well.We have recently rea ...
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 1