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Plus de 40 projets européens trouvés

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 TERMINÉ 

Clinical proof of concept through a randomised phase II study: a combination of immunotherapy and stereotactic ablative radiotherapy as a curative treatment for limited metastatic lung cancer (IMMUNOSABR)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2022,

IMMUNOSABR is geared towards opening up a new paradigm in treating metastatic cancer by obtaining clinical proof of concept for a novel bi-modal curative treatment strategy. High precision stereotactic ablative radiotherapy (SABR) is combined with immunotherapy to form a powerful synergistic anti-tumour strategy. The approach relies on the direct cytotoxic effect of SABR, the abscopal effect of ra ...
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 17

 TERMINÉ 

Multisystem Cell Therapy for Improvement of Urinary Continence (MUSIC)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

"Stress Urinary Incontinence (SUI) is a disease affecting over 200 million people worldwide. It represents a condition with a prevalence of 20-50% in women, thereby creating an immense socio-economic burden. The currently available treatment strategies entail various complications and offer only short-term relief to the patients. Tissue engineering using autologous cells offers a feasible alternat ...
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 5

 TERMINÉ 

Penumbral Rescue by Normobaric O=O Administration in Patients With Ischaemic Stroke and Target Mismatch ProFile: A Phase II Proof-of-Concept Trial (PROOF)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Ischemic stroke (IS), caused by occlusion of arteries that supply blood to the brain, remains a leading cause of mortality and morbidity in the world. Disruption of blood and oxygen supply to the brain leads to neuronal death in the ischemic core within minutes. The hypoperfused tissue surrounding the ischemic core, the penumbra, is at high risk for infarction over time but still salvageable. Neur ...
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 13

 TERMINÉ 

Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,

Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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 44

 TERMINÉ 

Transformations of Food in the Eastern Mediterranean Late Bronze Age (FoodTransforms)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

Mediterranean cuisine has long been perceived as a timeless constant, already linking the different societies around the sea by the 2nd mill. BC. The geographic frame was considered to be essential, whereas intercultural entanglements as transformative factors were neglected. By integrating archaeological, textual and scientific research, we will shed new light on the transformative power of cultu ...
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 2

 TERMINÉ 

Collective effects and optomechanics in ultra-cold matter (ColOpt)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The network “Collective effects and optomechanics in ultra-cold matter” (ColOpt) will train early-stage researchers (ESR) in fundamental science and applications in the areas of cold atom and quantum physics, optical technologies and complexity science to promote European competiveness in emergent quantum technologies. It consists of nine academic nodes and three companies from six European countr ...
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 13

 TERMINÉ 

Effect of ALlopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome (ALBINO)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and consequently about 5-20.000 infants per year in Europe.Hypothermic treatment became the only established therapy to improve outcome after perinatal hypoxic-ischemic insults. Despite hypothermia and neonatal inte ...
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 18

 TERMINÉ 

European training Network for In situ imaGing of dynaMic processes in heterogeneous subsurfAce environments (ENIGMA)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The ENIGMA network will train a new generation of young researchers in the development of innovative sensors, field survey techniques and inverse modelling approaches. This will enhance our ability to understand and monitor dynamic subsurface processes that are key to the protection and sustainable use of water resources. ENIGMA focuses mainly on critical zone observation, but the anticipated tech ...
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 11

 TERMINÉ 

Children’s Liver Tumour European Research Network (ChiLTERN)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Liver cancer in the paediatric population is rare with an incidence approximately 1-1.5 per million population. The commonest tumour seen in the childhood population is hepatoblastoma (HB), usually seen in young children and infants. Much rarer (about 10% of paediatric liver cancers) is hepatocellular carcinoma (HCC), usually seen in the teenage population and sometimes associated with underlying ...
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 21

 TERMINÉ 

Educational Network in Ocular Drug Delivery and Therapeutics (OcuTher)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

Ocular drug development has transformed from niche area to a major field in drug development in which many companies, including European big pharma has entered recently. Ocular drug development is a unique field in terms of drug targets and end-points of activity, local drug administration routes, tissue barriers and pharmacokinetics, drug delivery and formulation challenges and local toxicity iss ...
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 9

 TERMINÉ 

A Clinical Decision Support system based on Quantitative multimodal brain MRI for personalized treatment in neurological and psychiatric disorders (CDS-QUAMRI)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

A large number of neurological and psychiatric disorders lack objective criteria for primary diagnoses, early differential diagnosis with regard to subtypes in treatment response and disease progression or effective therapy monitoring resulting in a tremendous negative socio-economic impact. Scientific studies based on advanced MRI methods indicate that related patients show specific subtle change ...
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 7

 TERMINÉ 

Functional in vivo analysis of cholangiocarcinoma development, progression and metastasis. (CholangioConcept)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Genetic heterogeneity and complexity are hallmarks of metastatic solid tumors and therapy resistance inevitably develops upon treatment with cytotoxic drugs or molecular targeted therapies. Cholangiocarcinoma (CCC, or bile duct cancer) represents the second most frequent primary liver tumor and has emerged as a health problem with sharply increasing incidence rates, in particular of intrahepatic C ...
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 1

 TERMINÉ 

Site-directed RNA Editing to Manipulate RNA and Protein Function (RNArepair)

Date du début: 1 août 2015, Date de fin: 31 juil. 2020,

Enzymatically active RNA-guided proteins, like the RNA-induced silencing complex (RISC), are particularly versatile tools for the rationally programmed manipulation of genetic information. After successful re-addressing of various natural RNA-guided machineries it is now time to tackle the engineering of novel, user-defined tools. With this respect we have recently achieved the engineering of an R ...
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 1

 TERMINÉ 

Reconsidering European Contributions to Global Justice (GLOBUS)

Date du début: 1 juin 2016, Date de fin: 31 mai 2020,

GLOBUS critically assesses the EU’s impact on justice in a global system characterised by uncertainty, risk and ambiguity. GLOBUS defines a new research agenda for the study of the EU’s global role. This agenda directs attention to underlying political and structural challenges to global justice that are prior to the distributive problem, as well as to the fact that what is just is contested both ...
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 8

 TERMINÉ 

Conservative iron chelation as a disease-modifying strategy in Parkinson’s disease: a multicentric, parallel-group, placebo-controlled, randomized clinical trial of deferiprone (FAIR-PARK-II)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Parkinson’s disease (PD) is a major, chronic, non-communicable disease and the 2nd most frequent neurodegenerative disorder worldwide. Excess iron is primarily detected in the substantia nigra pars compacta, where dopaminergic neurons are exposed to high levels of oxidative stress produced by mitochondrial disorders and dopamine metabolism. Our previous preclinical, translational and pilot clinica ...
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 17

 TERMINÉ 

Biochemically modified messenger RNA encoding nucleases for in vivo gene correction of severe inherited lung diseases (BREATHE)

Date du début: 1 avr. 2015, Date de fin: 31 mars 2020,

Surfactant Protein B (SP-B) deficiency and Cystic Fibrosis (CF) are severe, fatal inherited diseases affecting the lungs of ten thousands of people, for which there is currently no available cure. Although gene therapy is a promising therapeutic approach, various technical problems, including numerous physical and immune-mediated barriers, have prevented successful application to date. My recent s ...
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 1

 TERMINÉ 

From the origin of Earth's volatiles to atmospheric oxygenation (O2RIGIN)

Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,

Aim of this project is to understand the connection between endogenic and exogenic processes of our planet that led to the redox contrast between Earth’s surface and interior. For this purpose the time constraints on atmospheric oxygenation can be refined and for the first time linked with a new approach to Earth’s endogenic processes like plate tectonics, mantle melting, volcanism, continent form ...
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 1

 TERMINÉ 

New geomodels to explore deeper for High-Technology critical raw materials in Alkaline rocks and Carbonatites (HiTech AlkCarb)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2020,

Five of the 20 raw materials identified by the European Commission as critical are commonly found in association with alkaline rocks and carbonatites (heavy and light rare earth elements, niobium, fluorspar, and phosphate). Other elements increasingly important for ‘hi-tech’ applications, and found in these rocks include hafnium (Hf), tantalum (Ta), scandium (Sc) and zirconium (Zr). In fact, there ...
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 12

 TERMINÉ 

Myopia: Fundamental understanding needed (MyFUN)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

The proposed ETN “Myopia: fundamental understanding needed” (MyFUN) provides an international, interdisciplinary platform to train young scientists at the interface of physics and biology, to study unresolved questions about the visual control of eye growth. It has been extensively documented that the growth of the eye is controlled by closed-loop visual feedback, using retinal image defocus as an ...
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 7

 TERMINÉ 

Spectral Fingerprints of Neuronal Interactions (SPECFIN)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,

"How does cognition result from complex neuronal interactions within and between brain regions? Substantial progress has been made understanding the functional properties of individual neurons, but we lack understanding of how they work together. Neuronal oscillations are ubiquitous in the brain. The frequencies of these oscillations reflect the biophysical properties of underlying circuit interac ...
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 1

 TERMINÉ 

Probing safety of nano-objects by defining immune responses of environmental organisms (PANDORA)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

PANDORA (Probing safety of nano-objects by defining immune responses of environmental organisms) shall assess the global impact of engineered nanoparticles (NP) on the immune responses of representative organisms covering all evolutionary stages and hierarchical levels from plants to invertebrates and vertebrates. Immunity is a major determinant of the survival and fitness of all living organisms, ...
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 10

 TERMINÉ 

Combatting Bacterial Resistance in Europe (COMBACTE-NET)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2019,

The emergence of Antibiotic-resistant bacteria (ARB) is a global problem, having recently been elevated to the top three threats identified by the World Health Organisation (WHO), and subject of numerous national and international government activities, including the Trans-Atlantic Task Force on Antimicrobial Resistance established by the US and EU presidencies. The estimated costs of ARB are aro ...
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 38

 TERMINÉ 

In the eye of the observer: Visual processing at the heart of the retina (switchBoard)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2019,

All visual information is broadcasted by an intra-retinal pathway formed by a group of neurons called bipolar cells. They collect photoreceptor signals in the outer retina and relay the signals to the inner retinal neurons. This transfer of visual information is far from passive: Each of the at least 10 bipolar cell types transforms the photoreceptor signals in a unique and highly specific way. As ...
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 11

 TERMINÉ 

ALK Activation as a target of TRAanslational Science (ALKATRAS): Break free from cancer (ALKATRAS)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

This ETN is embedded into an established international research programme; The European Research Initiative on Anaplastic Lymphoma Kinase (ALK)-related malignancies (ERIA; www.erialcl.net) is an existing and functional network of 13 partners, which will cosset and nurture a cohort of early stage researchers to become confident, competent, independent and well-connected European scientists with exc ...
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 13

 TERMINÉ 

Studying, Measuring and Altering Consciousness through information theory in the electrical brain (LUMINOUS)

Date du début: 1 mars 2016, Date de fin: 31 août 2019,

What is consciousness? Can it be measured? While humankind has struggled with these questions for millennia, our project will focus on more modest but nonetheless ambitious and related goals. Inspired by recent developments in neuroscience and the potential role of fundamental concepts such as information integration and algorithmic complexity, we will study, model, quantify, and alter observable ...
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 8

 TERMINÉ 

Diabetes Reversing Implants with enhanced Viability and long-term Efficacy (DRIVE)

Date du début: 1 juin 2015, Date de fin: 31 mai 2019,

Diabetes mellitus is a chronic disease characterised by high blood glucose due to inadequate insulin production and/or insulin resistance which affects 382 million people worldwide. Pancreatic islet transplantation is an extremely promising cure for insulin-sensitive diabetes mellitus (ISDM), but side effects of lifelong systemic immunosuppressive therapy, short supply of donor islets and their po ...
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 14

 TERMINÉ 

Interacting relativistic quantum dynamics via multi-time integral equations (Multi-time Integral Eqs.)

Date du début: 1 juin 2016, Date de fin: 31 mai 2019,

Multi-time wave functions are quantum-mechanical wave functions with N space-time arguments for N particles. They were suggested by the Nobel laureates Dirac, Tomonaga and Schwinger as a particularly natural way of achieving manifest Lorentz invariance in the Schrödinger picture. While for a long time it was not clear how to obtain consistent interacting dynamics for multi-time wave functions, thi ...
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 1

 TERMINÉ 

Exploring the combined role of genetic and non-genetic factors for developing Age-Related Macular Degeneration: A systems level analysis of disease subgroups, risk factors, and pathways (EYE-RISK)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

Age-related macular degeneration (AMD) is the world’s most important age-related blinding disorder. The current proposal utilises epidemiological data describing clinical phenotype, molecular genetics, lifestyle, nutrition, and in-depth retinal imaging derived from existing longitudinal European epidemiological cohorts and biobanks to provide three major insights needed for long-lasting prevention ...
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 13

 TERMINÉ 

Mutation-driven immunoediting of human cancer? (MUTAEDITING)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

"It is well documented that each human cancer has acquired a large number of mutations (50-500), some of which are drivers for tumorigenicity, others of which are indolent passengers. It has also been established that such mutations can be recognized by the patient´s T cells via the presentation of mutated peptides on HLA molecules of a tumor cell. If such immune responses against cancer mutations ...
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 1

 TERMINÉ 

The quantitative Bcl-2 interactome in apoptosis: decoding how cancer cells escape death (APOQUANT)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2019,

The proteins of the Bcl-2 family function as key regulators of apoptosis by controlling the permeabilization of the mitochondrial outer membrane. They form an intricate, fine-tuned interaction network which is altered in cancer cells to avoid cell death. Currently, we do not understand how signaling within this network, which combines events in cytosol and membranes, is orchestrated to decide the ...
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 2

 TERMINÉ 

EXtreme Tectonics and Rapid Erosion in Mountain Environments (EXTREME)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

"Tectonic plate corners are hotspots for high rates of continental deformation and erosion, and associated with human-relevant hazards including poorly understood earthquakes, destructive landslides, and extreme climate. A better understanding of continental deformation can mitigate these hazards. However, the coupling between climate and tectonic interactions at plate corners is a key unknown and ...
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 1

 TERMINÉ 

The impact of climate change on the uptake of arsenic into rice (RACe)

Date du début: 30 mars 2016, Date de fin: 29 mars 2019,

Rice is the staple food worldwide. Unfortunately, global rice yield is already falling behind population growth. One of the reasons for this is the presence of toxic arsenic (As) in many South(-East) Asian paddy soils, which is known to decrease rice growth and productivity. The current change in Earth’s climate is known to cause land loss due to desertification and inundation and lower (rice) cro ...
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 1

 TERMINÉ 

TWINNING for a Comprehensive Clinical Centre for the Diagnosis and Treatment of Parkinson's Disease (CENTRE-PD)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2019,

Unlike other EU member states, Luxembourg lacks a tradition for translation of fundamental research into clinical practice, which hampers health innovation and its adoption in cutting-edge medicine. During the last years, the Luxembourg Government made substantial efforts to position biomedicine as a key innovation driver. This highly successful biomedical initiative placed fundamental research on ...
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 3

 TERMINÉ 

Integrated Activities for the High Energy Astrophysics Domain (AHEAD)

Date du début: 1 sept. 2015, Date de fin: 28 févr. 2019,

We propose a set of integrated Activities in the High Energy Astrophysics Domain (AHEAD) in response to the INFRAIA-2014-2015 call Research Infrastructures for High EnergyAstrophysics.The overall objective of AHEAD is to integrate national efforts in high-energy Astrophysics and to promote the domain at the European level, to keep its community at the cutting edge of science and technology in this ...
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 26

 TERMINÉ 

MANAGING THE EFFECTS OF MULTIPLE STRESSORS ON AQUATIC ECOSYSTEMS UNDER WATER SCARCITY (GLOBAQUA)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Water and water-related services are major components of the human wellbeing, and as such are major factors of socio-economic development in Europe; yet freshwater systems are under threat by a variety of stressors (organic and inorganic pollution, geomorphological alterations, land cover change, water abstraction, invasive species and pathogens. Some stressors, such as water scarcity, can be a st ...
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 27

 TERMINÉ 

Cognitive Interaction in Motion (CogIMon)

Date du début: 1 févr. 2015, Date de fin: 31 janv. 2019,

Compliant control in humans is exploited in a variety of sophisticated skills. These include solitary actions such as soft catching, sliding, pushing large objects as well as joint actions performed in teams such as mainpulation of large scale objects or mutual adaptation through phyiscal coupling for learning, in walking or in execution of joint tasks. We refer to this advanced ability of organiz ...
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 10

 TERMINÉ 

DIabetes REsearCh on patient sTratification (DIRECT)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2019,

The overarching aims of the DIRECT consortium, consisting of 20 leading academic groups in diabetes and 5 EFPIA companies, are to identify biomarkers that address current bottlenecks in diabetes drug development and to develop a stratified medicines approach to treatment of type 2 diabetes with either existing or novel therapies.There is heterogeneity in who develops diabetes, the rate at which th ...
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 27

 TERMINÉ 

Biologically individualized, model-based radiotherapy on the basis of multi-parametric molecular tumour profiling (bio-iRT)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

High precision radiotherapy (RT) allows extremely flexible tumour treatments achieving highly conformal radiation doses while sparing surrounding organs at risk. Nevertheless, failure rates of up to 50% are reported for head and neck cancer (HNC) due to radiation resistance induced by pathophysiologic factors such as hypoxia and other clinical factors as HPV-status, stage and tumour volume.This pr ...
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 1

 TERMINÉ 

The Neurobiology of Decision-Making in Eating - Innovative Tools (NUDGE-IT)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

Nudge-it engages internationally leading experts in the neurobiology of motivational behaviour, the neuroscience of reward pathways, the neuroendocrinology of homeostatic regulation of appetite, experimental psychology, functional brain imaging, behavioural economics, and computational modelling. They will work together to develop new tools and approaches that can provide the evidence needed to in ...
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 10

 TERMINÉ 

Designing microProteins to alter growth processes in crop plants (miPDesign)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

The directed control of protein activity plays a crucial role in the regulation of growth and development of multicellular organisms. Different post-translational control mechanisms are known to influence the activity of proteins. Here, I am proposing a novel way to control the activity of proteins that function as multimeric complexes. MicroProteins, are small single-domain protein species that c ...
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 2