3 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation, in health and disease (4DCELLFATE)
Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,
Embryonic stem (ES) cells have the potential to differentiate into any type of cell as well as to renew indefinitely in culture. They hold great potential for the development of personalized medicines. However, the molecular mechanisms underpinning cell fate decisions by individual cells are poorly understood. There is compelling evidence that two large multi-protein machines, the Nucleosome Remod ...
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13
Participants partenaires
TERMINÉ
Epilepsy Pharmacogenomics: delivering biomarkers for clinical use (EpiPGX)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,
The purpose of the project is to identify genome-based biomarkers for use in clinical practice to individualise treatment of epilepsy, and stratify patients for clinical trials, aiming to avoid chronicity, prevent relapse and reduce adverse drug reactions (ADRs).The need for improved treatments in epilepsy is undoubted. Epilepsy is affects 50,000,000 people of all ages worldwide. Epilepsy is serio ...
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15
Participants partenaires
TERMINÉ
Towards FXR-mediated therapeutic intervention: Understanding how FXR integrates metabolic, endocrine and inflammatory signaling (mechFXR)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2014,
Nuclear receptors (NRs) are ligand-activated transcription factors that play vital roles in human physiology. 13% of all FDA-approved drugs target NRs, however they are associated with side-effects that limit their utility and safety. These side-effects are attributed to general activation of all NR transcriptional actions. Understanding the molecular mechanisms of NR transcriptional functions is ...
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