4 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Engineered Protein Capsids as Artificial Bacterial Organelles (EPCABO)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,
"Many proteins self-assemble into regular, shell-like, polyhedral structures. Protein capsids are useful, both in nature and in the laboratory, as molecular containers for diverse cargo molecules, including proteins, nucleic acids, metal nanoparticles, quantum dots, and low molecular weight drugs. They can consequently serve as delivery vehicles, bioimaging agents, reaction vessels, and templates ...
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TERMINÉ
Engineering of an Artificial Capsidic Enzyme for Aqueous Dirhodium Catalysis (ACCARC)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2014,
"Artificial metalloenzymes are expected to bring together the best of the two worlds of homogeneous and enzyme catalysis, combining broad substrate scope with high activity and reaction selectivity under mild conditions. Herein we propose to construct an artificial metalloenzyme based on a dirhodium active site in the capsid scaffold of the protein ferritin. Catalytically competent dirhodium compo ...
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TERMINÉ
Protein engineering for encapsulation and intracellular transport (ProtEngEncTrans)
Date du début: 1 avr. 2009, Date de fin: 31 mars 2011,
The main goal of this project is to develop a system for effective encapsulation and transport of negatively charged guests into living cells using an enginnered protein capsid. The research in prof. Hilvert's group demonstrated that it is possible to engineer the inner surface of a capsid formed by lumazine synthase from Aquifex aeolicus (AaLS) to accept positively charged guests while retaining ...
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TERMINÉ
Constructing an Artificial Enzyme for Olefin Metathesis (AEOM)
Date du début: 1 mars 2008, Date de fin: 28 févr. 2010,
"The introduction of stable and selective catalysts for olefin metathesis (OM) has considerably simplified the construction of double bonds. Herein we propose to tackle two areas of the OM reaction that have received little attention. First, we will address selectivity problems in an important type of OM reaction: metathesis cross-coupling or simply cross metathesis (CM). Second, we will examine t ...
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