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33 projets européens trouvés

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 TERMINÉ 

MicroRNA function in cardiac and metabolic disease (MICARUS)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

"Cardiovascular disease is the primary cause of morbidity and mortality worldwide. Despite numerous treatment options the prevalence of cardiovascular indications continues to increase, underscoring the need for new therapeutic strategies.In recent years, prominent roles of microRNAs (miRNAs) have been uncovered in a variety of cardiovascular disorders. miRNAs are short, single stranded RNAs that ...
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 1

 TERMINÉ 

Development of in vitro and in vivo strategies to avoid and cure male infertility (GROWSPERM)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2018,

"In many European countries at least 20% of young men exhibit sperm parameters below the lower WHO reference level and this will affect their fertility. Male infertility has a dramatic impact on the individual and couple’s psychological and social well-being and results in significant healthcare costs. Currently male patients that do not produce sperm have no therapeutic options to father children ...
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 7

 TERMINÉ 

Optimized esterase biocatalysts for cost-effective industrial production (OPTIBIOCAT)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2017,

"OPTIBIOCAT is a 48 months project aimed at developing biocatalysts based on feruloyl esterases (FAEs) and glucuronoyl esterases (GEs) for production of phenolic fatty- and sugar- esters with antioxidant activity for cosmetic industry, expanding the number/type of industrial biotransformations. Selected FAEs and GEs available within the consortium will be improved for their thermo- and solvent- re ...
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 16

 TERMINÉ 

Sustainable Biomass Conversions by Highly Efficient Catalytic Processes (SUBICAT)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

"The goal of a sustainable society requires the efficient use of renewable or sustainable materials and demands the development of selective new methodologies for the preparation of desirable products. In this context we require:(i) a change from traditional stoichiometric, high energy methods that produce huge amounts of chemical waste to mild and clean catalytic processes and(ii) a major step ch ...
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 7

 TERMINÉ 

The impact of chromosomal instability on health: Molecular causes and consequences of aneuploidy (PLOIDYNET)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Aneuploidy, an abnormal number of chromosomes, is a hallmark of cancer cells, affecting the majority of all human tumours. Aneuploidy arises when errors occur during mitosis, as the duplicated chromosomes are distributed between the two new daughter cells. Paradoxically, aneuploidy appears to have detrimental consequences for the physiology of untransformed cells in vitro, inhibiting rather than s ...
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 14

 TERMINÉ 

Controlling stochastic gene expression during development and stem cell differentiation (GeneNoiseControl)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,

The phenotypic differences between individual organisms can often be ascribed to underlying genetic and environmental variation. However, even genetically identical organisms in homogenous environments vary, suggesting that randomness in developmental processes such as gene expression may also generate diversity. My laboratory has intensively studied stochastic gene expression in microbial systems ...
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 1

 TERMINÉ 

Testing and validation of bispecific antibody combinations targeting treatment-resistant cancer stem cells using organoid-based screening tools: a new drug discovery paradigm (SUPPRESSTEM)

Date du début: 1 juin 2013, Date de fin: 30 nov. 2016,

Colorectal cancer (CRC) was diagnosed in 1.23 million people worldwide (EU 333,000) in 2008 and 608,000 (EU 148,000) died of the disease. While some new treatments have been advanced in CRC many have failed clinical testing; metastatic CRC is still largely incurable.In CRC, Cancer Stem Cells (CSC) are responsible for tumour progression and resistant to standard chemotherapies. The Wnt signal trans ...
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 5

 TERMINÉ 

Systems biology of liver cancer: an integrative genomic-epigenomic approach (MODHEP)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2016,

"Cancer is a complex disease involving multiple genetic and epigenetic events occurring, and influencing each other, over a long period of time. Understanding cancer, and ultimately developing effective targeted therapies, will therefore require that mutations and epigenetic alterations be systematically investigated during the multiple stages of disease development, from identifiable pre-neoplast ...
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 18

 TERMINÉ 

Microbial Resource Research Infrastructure - MIRRI (MIRRI)

Date du début: 1 nov. 2012, Date de fin: 30 avr. 2016,

MIRRI will be a pan-European distributed RI providing microbiological services, thus facilitating access to high quality microorganisms, their derivatives and associated data for research, development and application. It will connect resource holders with researchers and policy makers to deliver the resources and services more effectively and efficiently to meet the needs of innovation in biotechn ...
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 16

 TERMINÉ 

Zebrafish Regulomics for Human Health (ZF-HEALTH)

Date du début: 1 juil. 2010, Date de fin: 31 déc. 2015,

In recent years, the zebrafish has emerged as a new vertebrate model organism for biomedical research which offers a unique combination of traits: a short generation time, small size and efficient breeding procedures make it the best choice among vertebrates for forward genetic screening and small-molecule screens, including toxicology, while the transparent embryo and larva offers unique opportun ...
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 20

 TERMINÉ 

Yeast biodiversity as a source of innovations in food and health (CORNUCOPIA)

Date du début: 1 févr. 2011, Date de fin: 30 avr. 2015,

"Cornucopia will train a new generation of young scientists focusing on less studied yeasts with interesting traits, which could be applied in the food and health sectors. Yeasts are a divergent group of fungi that predominantly exist as unicellular organisms. The baker's yeast Saccharomyces cerevisiae is by far the best known because of its role in producing beverages, baking and recombinant drug ...
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 10

 TERMINÉ 

European large-scale functional genomics in the rat for translational research (EURATRANS)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2015,

Genetic studies in model organisms and humans, including human genome-wide association studies, have pinpointed genomic regions that contribute susceptibility to common disease. However, to date, these data have provided limited insights into the genes, molecular pathways and mechanisms underlying disease pathophysiology.The EU FP6 Euratools consortium has been a remarkable success that establishe ...
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 19

 TERMINÉ 

The role of long intergenic non-coding RNA in intestina stem cells (LincRNA)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,

Studies on long intergenic non-coding RNAs (lincRNAs) suggest an important role in development and cancer, however, functional lincRNAs in adult stem cells have been rarely defined. This project will study the role of lincRNAs in development of intestinal stem cell (ISC) one of the well identified adult stem cells. For this purpose, I will identify lincRNAs that are specifically expressed in ISCs ...
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 1

 TERMINÉ 

Molecular Targets Open for Regulation by the gut flora – New Avenues for improved Diet to Optimize European health (TORNADO)

Date du début: 1 sept. 2009, Date de fin: 31 août 2014,

... the impact of gut flora on the immune system/other organ systems. TORNADO aims to investigate molecular targets that are subject to regulation by gut flora and diet that sustain health. This will be done by an increasing level of specificity, from (1) investigations of dietary habits and health in population cohorts, through (2) intervention studies in humans and animals and (3) analyses of the i ...
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 24

 TERMINÉ 

Small RNA Mediated Epigenetics in Vertebrates (EPIRNAS)

Date du début: 1 août 2008, Date de fin: 31 juil. 2014,

Since the discovery of RNAi small RNA molecules have been under intense study. They have been shown to impact many different processes, ranging from development to organ function and carcinogenesis. Recently, it has become clear that many distinct small RNA families exist. However, all act through a member of the well-conserved Argonaute family of proteins. I try to understand how specificity of t ...
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 2

 TERMINÉ 

Organoids as infection model (InfO)

Date du début: 1 avr. 2012, Date de fin: 31 juil. 2014,

The mucosal surfaces of the human stomach and gut are in constant contact with bacteria and viruses. This encompasses the often mutually beneficial relationships with commensals as well as encounters with pathogens. The study of host-microbe interactions is hampered by a lack of suitable model systems: many bacteria or viruses cannot be cultured or existing models do not sufficiently recount the h ...
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 1

 TERMINÉ 

Developmental and Genetic Analysis of DNA Double-Strand Break Repair (DSBrepair)

Date du début: 1 mai 2008, Date de fin: 30 avr. 2014,

The DNA within our cells is constantly being damaged by both environmental and endogenous agents; of the many forms of DNA damage, the DNA double-strand break (DSB) is considered to be most dangerous. Correct processing of DSBs is not only essential for maintaining genomic integrity but is also required in specific biological processes, such as meiotic recombination and V(D)J recombination, in whi ...
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 2

 TERMINÉ 

Characterization of the role of CCBE1 during development and disease (Ccbe1 function)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2014,

The lymphatic vasculature is crucial for fluid homeostasis and immune function, and has a central role in many pathological conditions. The molecular mechanisms underlying lymphangiogenesis are poorly understood. Recently, CCBE1 has been identified in the host lab as a key regulator of lymphangiogenesis in zebrafish, mice and human. Importantly, CCBE1 has been associated to Hennekam Syndrome where ...
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 1

 TERMINÉ 

Aberrant ubiquitin-mediated proteolysis in oncogenesis (DGIRG)

Date du début: 1 mars 2010, Date de fin: 28 févr. 2014,

"The ubiquitin-proteasome system controls molecular networks that underlie fundamental cellular functions such as DNA replication, DNA repair, transcription, protein synthesis, cell differentiation and apoptosis. A large body of experimental and clinical data indicates that defects in the ubiquitin-dependent protein degradation are intimately linked with cancer pathogenesis. The main objective of ...
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 1

 TERMINÉ 

LGR receptors mark adult stem cells in multiple mammalian tissues (STEMCELLMARK)

Date du début: 1 mars 2009, Date de fin: 28 févr. 2014,

Self-renewal and repair of tissues in adult mammals is fueled by rare tissue stem cells. Identification and subsequent study of such adult stem cells depends strictly on the availability of molecular markers. To date, a paucity of single definitive markers has complicated the study of the biology of these rare cells. Our interest in the role of the Wnt pathway in intestinal homeostasis and cancer ...
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 1

 TERMINÉ 

"BIOactive highly porous and injectable Scaffolds controlling stem cell recruitment, proliferation and differentiation and enabling angiogenesis for Cardiovascular ENgineered Tissues" (BIOSCENT)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2013,

"Congenital and acquired diseases of the heart are the leading causes of morbidity and mortality in the world today; 7.2 million people die each year due to coronary heart disease, being the first cause of mortality in population above 60 years old, and the second cause after HIV in world wide young population. There is an urgent demand for new methods to repair and replace damaged cardiovascular ...
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 19

 TERMINÉ 

Indexing for Life (i4Life)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2013,

Partners to this proposal include the six major global programmes exploring the full extent of species diversity, a core dimension in human knowledge of global biodiversity.They are: GBIF and distribution modelling, the EBI/INDSC, and Barcode of Life initiatives and molecular diversity, IUCN Red Lists and the species conservation movement, and the Species 2000 Catalogue of Life taxonomic framework ...
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 18

 TERMINÉ 

4C technology: uncovering the multi-dimensional structure of the genome (4C)

Date du début: 1 sept. 2008, Date de fin: 31 août 2013,

The architecture of DNA in the cell nucleus is an emerging epigenetic key contributor to genome function. We recently developed 4C technology, a high-throughput technique that combines state-of-the-art 3C technology with tailored micro-arrays to uniquely allow for an unbiased genome-wide search for DNA loci that interact in the nuclear space. Based on 4C technology, we were the first to provide a ...
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 1

 TERMINÉ 

Translational Research in Europe – Applied Technologies for Osteoarthritis (TREAT OA)

Date du début: 1 janv. 2008, Date de fin: 30 juin 2013,

TREAT-OA will address the need for better treatment and diagnostics for osteoarthritis (OA) - the most common cause of disability in Europe. Currently there are no drugs that can cure, reverse or halt the disease. Nor are there yet reliable clinical biochemical markers for diagnosis or prognosis which is an impediment to the management of OA, costs of therapeutic trials and the development of dise ...
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 11

 TERMINÉ 

Novel high-performance enzymes and micro-organisms for conversion of lignocellulosic biomass to bioethanol (NEMO)

Date du début: 1 mai 2009, Date de fin: 30 avr. 2013,

The NEMO project provides novel efficient enzymes and microbes for 2nd generation bioethanol production. It generates through metabolic engineering and mutagenesis & screening approaches robust yeast strains that have a broad substrate range and can (co-)ferment C6 and C5 sugars to ethanol with high productivity (rate and yield), and that are significantly more stress tolerant, i.e. inhibitor, eth ...
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 21

 TERMINÉ 

Integrated approaches to study gene regulation during cellular differentiation (InteGeR)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,

Cellular differentiation from stem cells to fully functional mature cells is a multi step process executed by complex transcription programs. Once differentiated, cells must faithfully maintain their identity through cellular memory mechanisms. The utilisation of genetic information stored in linear DNA sequence occurs within the three dimensional context of chromatin, chromosomes and the nucleus, ...
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 9

 TERMINÉ 

European Consortium for Microbial Resource Centres (EMbaRC)

Date du début: 1 févr. 2009, Date de fin: 30 sept. 2012,

EMbaRC will establish a self-sustainable community of European Microbial Resource Centres representing a large bio-diversity and offering a wide-range of not only bio-resources but also expert services. These services will enable the development of new partnerships with public institutes in the field of biodiversity and will facilitate revenue-generating partnerships with the economic sector (larg ...
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 10

 TERMINÉ 

Development of a new diagnostic tool using DNA barcoding to identify quarantine organisms in support of plant health (QBOL)

Date du début: 21 mars 2009, Date de fin: 20 sept. 2012,

Development of accurate identification tools for plant pathogens and pests is vital to support European Plant Health Policies. For this project Council Directive 2000/29/EC is important, listing some 275 organisms for which protective measures against introduction into and their spread within the Community needs to be taken. Those threats are now greater than ever because of the increases in the v ...
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 21

 TERMINÉ 

European Consortium for Systematic Stem Cell Biology (EUROSYSTEM)

Date du début: 1 mars 2008, Date de fin: 31 août 2012,

EuroSyStem brings together elite European research teams to create a unique and world-leading programme in fundamental stem cell biology. By interconnecting complementary biological and computational expertise we will drive the generation of new knowledge on the characteristics of normal and abnormal stem cells. We will pave the way for application of systems methodology by measuring and modelling ...
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 25

 TERMINÉ 

Functional and genetical characterization of Ccbe1, a novel regulator of lymphangiogenesis (Ccbe1 and Lymphatics)

Date du début: 1 mars 2010, Date de fin: 29 févr. 2012,

Ccbe1 has recently been identified as an essential regulator of lymphangiogenesis in zebrafish. Loss of function of this secreted factor leads to a failure of lymphangioblast budding and a complete lack of lymphatics. Intriguingly, mutations in human CCBE1 are causative for a congenital lymphatic malformation disease, termed Hennekam syndrome (HS). The main goal of this project is to understand th ...
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 1

 TERMINÉ 

Identification and Genetic Profile Characterization of Lgr5 positive Colon Cancer Stem Cells (ICSC Lgr5)

Date du début: 1 mai 2009, Date de fin: 30 avr. 2011,

In the murine small intestine, the epithelium renews every five days. This vigorous self- renewing process is controlled by several secreted Wnt factors at the base of the crypt-villus axis. Lgr5/Gpr49 gene is a Wnt target gene that displays a complex expression pattern during embryogenesis, yet expression in most tissues subsides around birth. In adult mice, Lgr5 expression is restricted to rare, ...
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 1

 TERMINÉ 

Developing high-thoughput bioassays for human cancers in zebrafish (ZF-CANCER)

Date du début: 1 avr. 2008, Date de fin: 31 mars 2011,

"Recently the zebrafish has emerged as a new important system for cancer research because the zebrafish genome contains all orthologs of human oncogenes and forms tumors with similar histopathological and gene profiling features as human tumors. The zebrafish provides an in vivo vertebrate model for identifying novel mechanisms of cancer progression and for development of new anticancer compounds ...
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 9

 TERMINÉ 

TCF4 transcriptional program in crypt stem cells and resulting differentiated cells (gut gene regulation)

Date du début: 1 mars 2008, Date de fin: 28 févr. 2010,

The Wnt pathway is a key regulatory pathway in development and carcinogenesis. Many of the components of the pathway connecting Wnt to the transcription factor TCF4 have been identified. However, our knowledge of the regulation of TCF4 promoter and enhancer elements in response to the Wnt signal, resulting in development from a stem cell to a differentiated cell, is limited. Largely due to technic ...
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 2