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11 projets européens trouvés

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 TERMINÉ 

Biophysical networks underlying the robustness of neuronal excitability (CanaloHmics)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

The mammalian nervous system is in some respect surprisingly robust to perturbations, as suggested by the virtually complete recovery of brain function after strokes or the pre-clinical asymptomatic phase of Parkinson’s disease. Ultimately though, cognitive and behavioral robustness relies on the ability of single neurons to cope with perturbations, and in particular to maintain a constant and rel ...
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 1

 TERMINÉ 

Development and Epilepsy - Strategies for Innovative Research to improve diagnosis, prevention and treatment in children with difficult to treat Epilepsy (DESIRE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

DESIRE will focus on epileptogenic developmental disorders EDD, i.e. early onset epilepsies whose origin is closely related to developmental brain processes. A major cause of EDD are malformations of cortical development (MCD), either macroscopic or subtle. EDD are often manifested as epileptic encephalopathies (EE), i.e. conditions in which epileptic activity itself may contribute to severe cogni ...
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 29

 TERMINÉ 

Beta cell preservation via antigen-specific immunotherapy in Type 1 Diabetes: Enhanced Epidermal Antigen Delivery Systems (EE-ASI)

Date du début: 1 sept. 2012, Date de fin: 31 mai 2017,

Current approaches to improving glycaemic control in type 1 diabetes are centered on increasingly complex insulin delivery systems. However, less than 30% of patients can achieve target levels of glucose control with this approach even in a clinical trial setting and many patients are either unable or unwilling to make the personal commitment required. By contrast, preservation of even sma ...
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 8

 TERMINÉ 

Induction of Insulin-producing beta-cells Regeneration in vivo (BetaRegeneration)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

Diabetes has become one of the most widespread metabolic disorders with epidemic dimensions affecting almost 6% of the world’s population. Despite modern treatments, the life expectancy of patients with Type 1 diabetes remains reduced as compared to healthy subjects. There is therefore a need for alternative therapies. Towards this aim, using the mouse, we recently demonstrated that the in vivo fo ...
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 1

 TERMINÉ 

European Research Area Network on Illicit Drugs - Towards integrated European research in illicit drugs: cause and nature of drug problems; interventions and policies (ERANID)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

"ERANID, the European Area Network on Illicit Drugs, aims to improve cooperation in drug research in order to allow well-founded policy decisions.ERANID works both in the demand field and in the supply field. ERANID will promote multidisciplinary research activities in the field of socio-economic sciences and humanities. This may cover e.g. emerging drugs, vulnerable groups, changing demographics ...
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 13

 TERMINÉ 

Determination of specific components from “stromal PDAC signature” involved in PDAC Associated Neural Remodeling (PANR) and their use as clinical tool-box (Starget-in-PANR)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,

Pancreatic ductal adenocarcinoma (PDAC) is the most intractable of human malignancies. Survival rate at 5 years is very low (less than 5%). Patients are most of the time diagnosed while the disease has already spread out and benefits from surgical resection is often cut off due to local recurrence and lack of efficient chemotherapy. Indeed, it is urgent to develop new tools to be used by clinician ...
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 1

 TERMINÉ 

A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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 45

 TERMINÉ 

microRNA-155 expression control and function in innate immune inflammatory response (MIR155)

Date du début: 1 mars 2012, Date de fin: 29 févr. 2016,

MicroRNAs (miRNAs) are small non-coding RNAs which play critical roles in key biological processes, including immune response. miRNAs derive from transcripts (pri-miRNAs) which are processed by Drosha into intermediate hairpin precursors (pre-miRNAs). Pre-miRNAs are then processed by Dicer into mature forms of about 22 nucleotides. Mature miRNAs are loaded in the RNA-induced silencing complex (RIS ...
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 1

 TERMINÉ 

Mechanisms of retrotransposition in humans and consequences on cancer genomic plasticity (RETROGENOMICS)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,

Retrotransposons are a class of highly repetitive sequences, which are very abundant in the human genome. They disperse by an RNA-based copy-and-paste mechanism, called retrotransposition. This process can drive profound genome rearrangements. Although generally silent, they are expressed in germ cells, in the early embryo, and in embryonic stem cells, which occasionally results in genetic disease ...
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 1

 TERMINÉ 

NANOTECHNOLOGICAL TOOLKITS FOR MULTI-MODAL DISEASE DIAGNOSTICS AND TREATMENT MONITORING (NAMDIATREAM)

Date du début: 1 juil. 2010, Date de fin: 30 juin 2014,

NAMDIATREAM will develop a cutting edge nanotechnology-based toolkit for multi-modal detection of biomarkers of most common cancer types and cancer metastases, permitting identification of cells indicative of early disease onset in a high-specificity and throughput format in clinical, laboratory and point-of-care devices. The project is built on the innovative concepts of super-sensitive and highl ...
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 24

 TERMINÉ 

Innovative contrast imaging by non-linear optics (NLO) for the observation of biological tissues in vivo and in real time, at cellular and molecular levels (CARS Explorer)

Date du début: 1 mars 2008, Date de fin: 31 août 2011,

The CARS EXPLORER seeks to demonstrate the concept of innovative light-based contrasting technologies for functional in situ imaging in life science and biomedical research. Our ultimate goal is to develop an endoscope based on non-linear optics (NLO) and laser pulse phase shaping. Non linear laser pulse interactions with living tissues provide unique possibilities, such as an absence of sample pr ...
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 7