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The histone variant macroH2A1 (mH2A1) is associated with gene repression but the molecular mechanisms by which it exerts its function are largely unknown. mH2A is recruited to the IL-8 promoter by ATF-2 where it functions as a transcriptional repressor. Interestingly, macroH2A1 has been shown to bind O-acetyl-ADP-ribose (OAADPR).The functional consequences of this interaction are unknown. This pro ...