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 TERMINÉ 
The musculoskeletal apparatus is probably the organ system where the need for the integrative approach advocated by the Virtual Physiological Human (VPH) initiative is most pronounced. The neuromotor control involves the entire body, whereas the processes involved in muscle twitching, bones and muscle adaptation, musculoskeletal aging, and in most musculoskeletal diseases take place at the molecul ...
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 6

 TERMINÉ 
In recent years, various terms – the Virtual Physiological Human (VPH), Integrative Biology, Physiome Research – have been used to describe the trend in biomedical research towards the consideration of systemic processes. These phenomena are commonly observed in living organisms but cannot be explained within a single sub-system but reflect, rather, systemic outcomes that result from the interacti ...
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 5

 TERMINÉ 

Osteoporotic Virtual Physiological Human (VPHOP)

Date du début: 1 sept. 2008, Date de fin: 31 oct. 2012,

Nearly four million osteoporotic bone fractures cost the European health system more than 30 billion Euro per year. This figure could double by 2050. After the first fracture, the chances of having another one increase by 86%. We need to prevent osteoporotic fractures. The first step is an accurate prediction of the patient-specific risk of fracture that considers not only the skeletal determin ...
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 TERMINÉ 

Virtual Pathological Heart of the Virtual Physiological Human (VPH2)

Date du début: 1 juil. 2008, Date de fin: 31 oct. 2011,

Heart failure accounts for almost a quarter of all admissions to hospital for cardiovascular events, has a high mortality (median survival around 18 months), and places a great burden on all healthcare systems, with estimated direct costs of £905m (?1350m) in the United Kingdom in 2000, 2% of total NHS expenditure.VPH2 aims to develop a patient-specific computational modelling and simulation of th ...
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