8 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Paratexts of the Bible. Analysis and Edition of the Greek Textual Transmission (PARATEXBIB)
Date du début: 1 oct. 2014, Date de fin: 30 sept. 2019,
This project takes a new look at an old text. The Bible is a fundamental book for the history of religious beliefs, cultural history, art history as well as many other fields. For centuries it has been read and copied multiple times. Thousands of medieval manuscripts survive. The process of transmission is considered here from a totally new perspective. While biblical manuscripts have so far been ...
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2
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TERMINÉ
Metabolic regulation of growth and body composition: key modulators of long-term health (META-GROWTH)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
Nutrient exposure during pregnancy and childhood strongly affects growth and induces persistent metabolic programming of lifelong health. Recent data show that obesity and related disorders are induced by both fast childhood weight gain, and by formula feeding that promotes higher weight gain than breastfeeding. Lower protein in infant formula at levels similar to breast milk normalizes early weig ...
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1
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TERMINÉ
Identification and modulation of pathogenic Amyloid beta-peptide species (AMYLOID)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,
The frequency of Alzheimer's disease (AD) will dramatically increase in the ageing western society during the next decades. Currently, about 18 million people suffer worldwide from AD. Since no cure is available, this devastating disorder represents one of the most challenging socio-economical problems of our future. As onset and progression of AD is triggered by the amyloid cascade, I will put p ...
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1
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TERMINÉ
Neuroprotection in Multiple Sclerosis: From Molecular Imaging to Screenable Models (NEMESIS)
Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,
"Multiple Sclerosis (MS) is an inflammatory CNS disease that affects more than 2.5 million individuals worldwide. Damage to axonal connections determines the functional deficits of MS patients. How axons are damaged in MS is only incompletely understood. Using in vivo multiphoton imaging we have discovered a novel axon loss process that underlies axonal damage in experimental and human neuroinflam ...
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1
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TERMINÉ
Role of Nano-Titanium Dioxide Immunotoxicity in Infectious Disease paThology (TiTOXPATH)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
The rise in use of nanotechnology has significantly increased risks of human exposure and interaction of nanoparticles with the immune system, potentially jeopardizing host responses to infection. There is a critical need to define the functional immunological consequences of chronic nanoparticle exposure. Lack of this knowledge could potentially confound efforts to prevent, diagnose, and treat in ...
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1
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TERMINÉ
Exploring novel pathways governing immunity and leukemia by studying the genetic basis of human myeloid cell defects - from genetics to gene therapy (EXPLORE)
Date du début: 1 janv. 2012, Date de fin: 30 juin 2017,
Genomic system biology approaches offer new aspects to understand the basis of diseases and to develop new therapeutic strategies. Here, we propose to study rare human variants of the immune system to provide novel explanations of mechanisms governing inflammation and leukemogenesis. Following a full circle of translational research, our group has previously defined several novel clinical entities ...
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1
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TERMINÉ
Specificity of Rc3h1/2 proteins in post-transcriptional control of immunity and autoimmune disease (RC3H1/2-SPECIFICITY)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2016,
We are constantly protected by our adaptive immune system. Its functioning requires precise control of gene expression in lymphocytes, since deregulation can cause autoimmune diseases (affecting ~5% of our population) as well as allergic reactions (~9-16%, with increasing incidence). Post-transcriptional control of gene expression is crucial in many immune decisions, however the determinants of sp ...
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2
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TERMINÉ
Structure-Function Analysis of the Chemokine Interactome for Therapeutic Targeting and Imaging in Atherosclerosis (ATHEROPROTECT)
Date du début: 1 avr. 2010, Date de fin: 31 mars 2016,
Atherosclerosis is characterized by chronic inflammation of the arterial wall. Mononuclear cell recruitment is driven by chemokines that can be deposited e.g. by activated platelets on inflamed endothelium. Chemokines require oligomerization and immobilization for efficient function, and recent evidence supports the notion that heterodimer formation between chemokines constitutes a new regulatory ...
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