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16 projets européens trouvés

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 TERMINÉ 

Signalling compartmentalization and vesicle Trafficking at the Phagocytic Synapses (STEPS)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2019,

A key feature of the immune response is its specificity and macrophages must be able to discriminate precisely between an infectious stimulus and a non-infectious one and tune their response in accordance with the molecular context in which the target particle is recognized. In recent years, scientists have proposed the concept of the phagocytic synapse, to stress the fact that a particle does not ...
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 2

 TERMINÉ 

Epigenetics and microRNAs in Myocardial Function and Disease (CARDIOEPIGEN)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2018,

Heart failure (HF) is the ultimate outcome of many cardiovascular diseases. Re-expression of fetal genes in the adult heart contributes to development of HF. Two mechanisms involved in the control of gene expression are epigenetics and microRNAs (miRs). We propose a project on epigenetic and miR-mediated mechanisms leading to HF.Epigenetics refers to heritable modification of DNA and histones that ...
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 1

 TERMINÉ 

MEsenchymal stem cells to Reduce Liver INflammation (MERLIN)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

"Prevalence of liver disease is c6% (29 million people) in the EU with mortality rates from chronic liver diseases estimated at 14.3 per 100.000 in the EU-25 in 2004. Most liver diseases have a significant inflammatory component that underpins liver damage and fibrogenesis, yet current therapies have limited effectiveness. Safe novel anti-inflammatory therapies would satisfy a large unmet need for ...
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 9

 TERMINÉ 

Advanced Immunization Technologies (ADITEC)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2017,

Vaccines so far have been developed mostly by following an empiric approach. To prevent and possibly cure unresolved and emerging infectious diseases we need to fully exploit the potential of the human immune system. Progress in science and technology makes it possible to achieve what was previously deemed impossible. The scope of this project is to produce knowledge necessary to develop novel and ...
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 53

 TERMINÉ 

BeTheCuRE (BTCURE)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2017,

BTCure is based on the recognition that RA is a heterogeneous disease where a major subset involves adaptive immunity, and that animal models have to develop the line with the different subsets of the human diseases in order to be optimally used for drug discovery and drug evaluation. Our aim is to develop an understanding of the early process in human arthritis subsets and the animal models that ...
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 41

 TERMINÉ 

mRNA translational regulation in heart failure (MRNA IN HEART)

Date du début: 1 avr. 2014, Date de fin: 29 août 2016,

Protein synthesis is among the principal biological processes underlying cardiac hypertrophy, an early event in many forms of heart failure (HF). It is associated with worsening of cardiac function after long-term exposure to noxae. The rate-limiting step of protein synthesis is mRNA translation, which is controlled by factors involved in initiation and/or elongation. 4E-BPs regulate the translati ...
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 1

 TERMINÉ 

Improving adoptive T cell transfer immunotherapy for cancer with T memory stem cells (STEMIMMUNE)

Date du début: 1 août 2012, Date de fin: 31 juil. 2016,

"Here we seek to identify the genetic program at the basis of T memory stem cell persistence in vivo and use their properties to improve the adoptive T cell transfer for the treatment of human cancer. Adoptive cell transfer with tumour-specific T lymphocytes is currently under test in the clinic for the treatment of solid tumours such as melanoma. However, the poor persistence in vivo of adoptivel ...
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 1

 TERMINÉ 

TargetIng novel MEchanisms of Resolution in inflammation (TIMER)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

Resolution of inflammation is a key determinant of pathology, and an active process which involves diverse pathways and molecules. The general objective of the TIMER Consortium is to identify and validate new molecules involved in the resolution of inflammation as a basis for the development of innovative therapeutic strategies in chronic inflammatory and autoimmune diseases. The project will invo ...
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 13

 TERMINÉ 

ICT-enabled, cellular artificial liver system incorporating personalized patient management and support (d-LIVER)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,

d-LIVER applies scenario-driven development methodologies to address an unmet need for bio-artificial liver support via continuous detoxification as remote transient therapy at the Point-of-Need. The liver is a complex organ with various vital functions in synthesis, detoxification and regulation; its failure is life-threatening and the only curative treatment is transplantation. Whilst awaiting t ...
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 15

 TERMINÉ 

Role of microRNAs 143 and 145 in cardiovascular physiology and disease: from bench to bedside (From Bench to Bedside)

Date du début: 1 août 2011, Date de fin: 31 juil. 2015,

Cardiometabolic diseases (CMD) (such as atherosclerosis, hypertension) are the primary cause of death and disability in the Western world. Although lifestyle programmes and therapeutic approaches have significantly reduced the socio-economic burden of CMD, a large number of events still cannot be avoided (residual risk). Neointimal hyperplasia is the principal pathogenic occurrence underlying athe ...
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 2

 TERMINÉ 

Global microRNA profiling of normal and Pbx1-null hematopoietic stem cells and progenitors for the identification of new regulators of the balance between self-renewal and differentiation (HSC self-renewal)

Date du début: 1 août 2010, Date de fin: 18 mars 2015,

MicroRNAs (miRNAs) are non-coding RNA molecules that repress translation and stability of target mRNAs. They are key regulators of cell cycle and differentiation in embryonic stem cells, and are differentially expressed among many tumors, but their function in adult stem cells (SC) is not known. Somatic SC are able to self-renew, at the same time generating a differentiated progeny that replenish ...
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 1

 TERMINÉ 

Characterization of NK cell distributions and functions in human tissues in HIV-1 pathogenesis (CNKHIV)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2015,

"HIV is an urgent global health problem and a safe and effective vaccine is desperately required. Although many studies have shown that the innate immune system, and in particular, natural killer (NK) cells play a central role in determining the quality of the host immune response to HIV -1, the full host beneficial potential of the anti-HIV-1 NK-mediated activity can not be realized in vivo, as N ...
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 1

 TERMINÉ 

A Coordinated and Structured International Post-Doctoral Program to Foster Trans-national Mobility and Independent Career of Scientists in Biomedicine (SIPOD)

Date du début: 16 mars 2009, Date de fin: 15 sept. 2014,

"This program encompasses the coordinated action of three major Biomedicine Research Centers and a Biotech shell in Lombardy, to launch a new Structured International Post-Doctoral program (SIPOD). These research centers operate in conjunction with the Scuola Europea di Medicina Molecolare (SEMM) whose aim is to promote the training and research of young scientists within emerging sectors of biome ...
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 4

 TERMINÉ 

The humoral innate immune system: long pentraxins as a paradigm (HIIS)

Date du début: 1 juin 2009, Date de fin: 31 mai 2014,

"The innate immune system consists of humoral and a cellular arm, but attention has largely been focused on cells and their receptors. The humoral innate immune system (HIIS) is generally represented as a collection of diverse molecules (collectins, ficolins, pentraxins). A tenet underlying this application is that in spite of molecular diversity, the HIIS is built on general principles and logic ...
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 1

 TERMINÉ 

Systems Biology of T-cell Activation in Health and Disease (SYBILLA)

Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,

T-cell activation, whether induced by pathogens or auto-antigens, is a complex process relying on multiple layers of tightly controlled intracellular signalling modules that form an intricate network. Defects in this network can cause severe and chronic disorders such as autoimmune diseases. Although 5% of the population suffer from these diseases, only a few therapeutic treatments are available. ...
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 22

 TERMINÉ 

Normalisation of immune reactivity in old age – from basic mechanisms to clinical application (TOLERAGE)

Date du début: 1 avr. 2008, Date de fin: 30 sept. 2012,

"When restoration of the immune response in older age is the target of basic and clinical research, boosting innate and adaptive immunity, e.g. by more efficient vaccination strategies, is the general approach. However, TOLERAGE has a fundamentally different focus, i.e. restoring the age-dependent decline of auto-tolerance that underlies the development of the paradigmatic age-associated diseases ...
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 10