6 projets européens trouvés
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TERMINÉ
Mechanisms of homeostatic plasticity in the intact mouse visual cortex (HOMEOSTASIS_IN_VIVO)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2018,
Changes in input lead to changes of synaptic circuits in the brain via a combination of synapse specific Hebbian plasticity and cell-wide homeostatic plasticity. While Hebbian plasticity has been well studied, there are still a number of outstanding fundamental questions related to homeostatic plasticity. We have previously developed a paradigm that allows us to monitor changes to multiple homeost ...
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2
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TERMINÉ
Understanding Mechanisms of Human Social Interaction using Interactive Avatars (INTERACT)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2018,
Human social interaction depends on non-verbal unconscious behaviour as much as on verbal signals. Mimicry (unconscious copying of actions) is a good example of a social behaviour which is caused by and has consequences for our evaluation of others. However, studying mimicry with traditional methods is hard because of the trade-off between good experimental control and realistic social interacti ...
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2
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TERMINÉ
Cultured Liver Organoids for Investigation and Treatment of Inherited Cholestatic Diseases (CLOC)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,
"Bile synthesis and secretion are crucial to liver function and involve multiple proteins. Disorders due to defects in this process (Inherited Cholestatic Disorders, ICDs) lead to progressive liver disease. Many ICD patients do not respond to medical treatment and need liver transplantation (LT). Although ICDs are rare, multifactorial cholestatic diseases are common and many patients will benefit ...
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1
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TERMINÉ
Autophagy as a cancer treatment (CANCERPHAGY)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2018,
Cancer is one of the most prevalent human killer diseases. Autophagy, a lysosome-mediated process that degrades cellular components and damaged organelles, has recently emerged as an important player in cancer. Indeed, autophagy inhibition promotes cancer initiation through generation of genomic instability and inflammation, whereas in contrast, autophagy activation is often required to sustain gr ...
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1
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TERMINÉ
Activity-Dependent Maturation of Inhibitory Processing in the Spinal Dorsal Horn (ADMIP)
Date du début: 1 mars 2015, Date de fin: 28 févr. 2018,
In the early postnatal period neonates are particularly sensitive to touch, often responding with exaggerated reflexes and whole-body movements to an isolated cutaneous stimulus. This suggests a predominance of excitation over inhibition in spinal sensory networks, which may facilitate activity-dependent synaptic strengthening. We have recently shown that neonatal hypersensitivity to touch is due ...
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1
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TERMINÉ
The development of the hippocampal spatial representation system (DEVSPACE)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,
This proposal will address how a multimodal cognitive system, the neural representation of space in the hippocampus, emerges during development. There is a long tradition in neuroscience of studying the development of primary sensory systems, but fewer studies have concentrated on the development of brain networks supporting higher-order cognitive representations.Our recent findings (Wills, Cacucc ...
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