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Establishment of a novel CML model using Multi-Hit technology (CMLMULTIHIT)
Date du début: 17 mai 2010, Date de fin: 16 mai 2012,
"The chronic phase of chronic myeloid leukaemia (CML) is characterized by the expression of the chimeric BCR-ABL gene, extended survival, and profligate growth of maturing granulocyte stemline. It provided the rationale for producing first imatinib and then a series of small molecules designed to inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein, all of which can induce complete cyto ...
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