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15 projets européens trouvés

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 TERMINÉ 

Synaptic dysfunction in Neurodegenerative Diseases (SYNDEGEN)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Neurodegenerative diseases (NDDs) of aging are a growing burden on societies. Although studies on the degeneration of neurons have been a main focus of research, increasing evidence points to synapses as the site where Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD) begin. There is growing evidence that synapses are sites of early and aberrant protein misfolding, a ...
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 8

 TERMINÉ 

Decoding the epigenetic signature of memory function in health and disease (DEPICODE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

The emerging field of neuroepigenetics investigates processes such as histone-acetylation in the context of neuronal plasticity, memory function and brain diseases. My group has significantly contributed to this novel research field. It is however fair to say that the role of “epigenetics” in memory function is still met with some skepticism in the neurosciences, which is in part due to the fact t ...
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 1

 TERMINÉ 

Synaptic Dysfunction in Alzheimer Disease (SyDAD)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2019,

Given an overwhelming increase of dementia costs and an aging population, there is an urgent need for finding novel therapies for Alzheimer Disease (AD). We are, however, facing a large number of failed clinical trials and a retraction of the nervous system R&D programmes from several big pharmaceutical companies. Increased collaboration between academia and the private sector is required to overc ...
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 6

 TERMINÉ 

C9orf72 repeat expansion in FTD/ALS - from mechanisms to therapeutic approaches (DPR-MODELS)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

"Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal neurodegenerative diseases with overlapping genetics and pathology. The most common known cause is expansion of a GGGGCC repeat in the first intron of the gene C9orf72. I discovered that the repeat region is translated in all three reading frames into aggregating dipeptide-repeat (DPR) proteins despite its intronic lo ...
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 1

 TERMINÉ 

Understanding the balance between functional and deleterious interactions of alpha-synuclein with lipid bilayers (toxiclipasyn)

Date du début: 1 mai 2017, Date de fin: 30 avr. 2019,

Proteins are among the most essential molecules of life. In order to fulfil their native function(s) they need to adopt a well-defined three-dimensional structure. However, under some circumstances, proteins can misfold and/or form toxic amyloid structures, which are the hallmark of a range of diseases including type 2 diabetes and neurodegenerative diseases. In particular, the small pre-synaptic ...
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 1

 TERMINÉ 

SPATIAL NAVIGATION – A UNIQUE WINDOW INTO MECHANISMS OF COGNITIVE AGEING (AGESPACE)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

"By 2040, the European population aged over 60 will rise to 290 million, with those estimated to have dementia to 15.9 million. These dramatic demographic changes will pose huge challenges to health care systems, hence a detailed understanding of age-related cognitive and neurobiological changes is essential for helping elderly populations maintain independence. However, while existing research in ...
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 1

 TERMINÉ 

The Extracellular Matrix in Epileptogenesis (ECMED)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

Over 50 million people worldwide have epilepsy and 30% are resistant to our present therapies. Epilepsy, therefore, comprises a major burden to society and so there is a pressing need for new approaches to treatment. The brain extracellular matrix (ECM) plays a critical role in governing brain excitability and function. Although research into the role of the ECM in neuronal signalling and network ...
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 10

 TERMINÉ 

Human Brain Project Specific Grant Agreement 1 (HBP SGA1)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses I ...
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 126

 TERMINÉ 

New magnetic resonance techniques to determine the dynamic structure of mitochondrial outer membrane proteins and their complexes (DYNAMOM)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2017,

Membrane proteins are coded by about 30% of the genes in the human genome and are primary targets for the action of drugs. I propose an interdisciplinary approach that will provide insight into the dynamic structure of membrane proteins of the outer mitochondrial membrane at unprecedented detail with respect to spatial resolution and time scale separation. Analysis of the dynamics and structure of ...
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 2

 TERMINÉ 

Integrated European –omics research project for diagnosis and therapy in rare neuromuscular and neurodegenerative diseases (Neuromics)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

Neurodegenerative (ND) and neuromuscular (NM) disease is one of the most frequent classes of rare diseases, affecting life and mobility of 500,000 patients in Europe and millions of their caregivers, family members and employers. This NEUROMICS project brings together the leading research groups in Europe, five highly innovative SMEs and relevant oversea experts using the most sophisticated Omics ...
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 20

 TERMINÉ 

Extracellular brain proteolysis in neuronal plasticity and neuropsychiatric disorders (EXTRABRAIN)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

Brain disorders comprise a major burden for the society. Recent analyses of the neuropsychiatric disease-related gene polymorphisms as well as genomics and proteomics have identified the components of the extracellular matrix (ECM) and the cell adhesion molecules (CAMs) in the brain as pivotal for those diseases. The ECM/CAMs span the synaptic cleft and regulate the synaptic dynamics. Furthermore, ...
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 9

 TERMINÉ 

Understanding the regulation of physiological protein aggregation with age (AggregatingProteome)

Date du début: 1 sept. 2012, Date de fin: 3 mars 2017,

Aging is a major risk factor for neurodegeneration, cancer and heart disease. Understanding what goes wrong with age, in particular how the proteome becomes dysfunctional may help to slow down or prevent these age-dependent diseases. Until recently, it was widely assumed that protein aggregation was mainly restricted to the extensive aggregation of a few hallmark proteins in diseases such as neuro ...
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 1

 TERMINÉ 

Gene-Environment Interactions in the Etiopathogenesis of Parkinson's Disease: Role of Inflammation (PDGENNI)

Date du début: 1 juil. 2012, Date de fin: 30 juin 2016,

Parkinson's disease (PD) is a relentlessly progressive disease characterized clinically by bradykinesia, rigidity, and resting tremor. Clinical manifestations of PD are not apparent until 80~85% of neurons in the substantia nigra pars compacta (SNc) have degenerated and striatal dopamine (DA) levels are depleted by 60~80%. At the time of diagnosis, the therapeutic window and the potential to inter ...
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 1

 TERMINÉ 

Structural analysis of the conformational transitions of the K18 fragment of human tau driven by Hsp70 action (HSP70-TAU NMR)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2016,

The proteins Tau and α-synuclein are causative agents of several neurodegenerative diseases including Alzheimer’s and Parkinson’s disease. In physiological conditions these neurotoxic proteins adopt a disordered conformation but undergo conformational transitions leading to their aggregation and amyloid fibril formation under neuronal stress. ATP-driven molecular chaperones of the heat-shock prote ...
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 1

 TERMINÉ 

BrainTrain: Integrative neuroscience school on brain function and disease (BrainTrain)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,

Brain disorders, in particular neurodegenerative diseases and mental illnesses are among the most prevalent and debilitating diseases. Because they are chronic, quality of life and socio-economic prospects are dramatically impaired. Increased life expectancy further enhances the impact of brain dysfunction on society. In coming decades this burden will grow into one of most pressing and costly pro ...
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 14