10 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Human Puripotent Stem Cell Registry (hPSCreg)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
European registry for human embryonic stem cell lines
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2
Participants partenaires
TERMINÉ
A multicenter phase IIb study using HLA-unmatched allogeneic placenta-derived stromal cells (PLX-PAD) for the treatment of severe critical limb ischemia accompanied by mechanistic studies (PACE)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
PACE aims to transform the treatment of patients suffering from critical limb ischemia (CLI), a disease with high medical need, because of limited treatment options and poor outcome by applying a novel, off-the-shelf allogeneic placenta-derived stromal cell product (PLX-PAD). Despite improvements in medical care and revascularization, patients with CLI continue to have a high risk of major amputat ...
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9
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TERMINÉ
HARMONIzation and integrative analysis of regional, national and international Cohorts on primary Sjögren’s Syndrome (pSS) towards improved stratification, treatment and health policy making (HarmonicSS)
Date du début: 1 janv. 2017, Date de fin: 30 juin 2020,
HarmonicSS vision is to create an International Network and Alliance of partners and cohorts, entrusted with the mission of addressing the unmet needs in primary Sjogren Syndrome; working together to create and maintain a platform with open standards and tools, designed to enable secure storage, governance, analytics, access control and controlled sharing of information at multiple levels along wi ...
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39
Participants partenaires
TERMINÉ
Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases (PRECISESADS)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
We concur to the IMI on “Reclassification of SLE, connective tissue diseases and RA” call by presenting a proposal aimed at using the power of OMICs, and bioinformatics to identify new classifications for diseases known to share common pathophysiological mechanisms. Such knowledge has not been applied to individual patients, depriving them from potential benefits in terms of the use of new therape ...
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30
Participants partenaires
TERMINÉ
BeTheCuRE (BTCURE)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2017,
BTCure is based on the recognition that RA is a heterogeneous disease where a major subset involves adaptive immunity, and that animal models have to develop the line with the different subsets of the human diseases in order to be optimally used for drug discovery and drug evaluation. Our aim is to develop an understanding of the early process in human arthritis subsets and the animal models that ...
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41
Participants partenaires
TERMINÉ
Protective and pathogenic immunological memory and its organisation by stroma cells (IMMEMO)
Date du début: 1 août 2011, Date de fin: 31 juil. 2016,
"Immunological memory provides immunity against recurrent pathogens, but also can induce and regulate immunopathology. In chronic immune-mediated diseases, a ""pathogenic"" immunological memory probably is the essential driver of inflammation, refractory to physiological regulation and state-of-the-art therapeutic immunosuppression, and thus a challenge for the development of novel, curative thera ...
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1
Participant partenaire
TERMINÉ
OSTEOIMMUNE - Unraveling the Interactions between the Immune System and Bone (OSTEOIMMUNE)
Date du début: 1 juin 2012, Date de fin: 31 mai 2016,
Inflammatory rheumatic diseases affect millions of European citizens causing chronic pain, disability and premature death. Curative treatments are lacking. Conventional research often focuses on one single organ system such as the bone or the immune system and. ignores interactions between organ systems. OSTEOIMMUNE is a supra-disciplinary training network that targets this gap by providing compre ...
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12
Participants partenaires
TERMINÉ
The role of NKG2D in CD4+ T cell function and autoimmunity (NKG2D-IMMUNO)
Date du début: 1 mai 2013, Date de fin: 29 mai 2016,
More than 5 million people in Europe live with inflammatory bowel disease (IBD) or rheumatoid arthritis (RA). Both diseases are characterized by chronic inflammation partially mediated by inappropriate T cell response. Effector T-cell responses can be modulated by competing positive or negative costimulatory signals, and dysregulated balance between these signals may lead to chronic autoimmune inf ...
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1
Participant partenaire
TERMINÉ
EUropean TRanslational training for Autoimmunity & Immune manipulation Network (EUTRAIN)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
Immune-mediated inflammatory diseases (IMID) are important health challenges in Europe and beyond, afflicting an estimated 5-8% of the total population. IMID with an onset during childhood such as Juvenile Idiopathic Arthritis (JIA) cause particular concern as pediatric patients form an especially vulnerable group. Currently there is no safe and cost-effective cure for JIA and related juvenile IMI ...
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11
Participants partenaires
TERMINÉ
Long-term PHARMacovigilance for Adverse effects in Childhood arthritis focussing on Immune modulatory drugs (PHARMACHILD)
Date du début: 1 avr. 2011, Date de fin: 30 sept. 2014,
Until the age of biotechnology, treatment options for children and adolescents with severe arthritis, inflammatory bowel diseases and other serious diseases with chronic inflammation were limited. Advances in understanding the pathophysiology of the inflammatory responses have led to the development of a new class of medications that are capable of inhibiting selectively the principal mediators of ...
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