11 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
The Role of Ectopic Adipocyte Progenitors in Age-related Stem Cell Dysfunction, Systemic Inflammation, and Metabolic Disease (AgeingStemCellFate)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,
Ageing is accompanied by ectopic white adipose tissue depositions in skeletal muscle and other anatomical locations, such as brown adipose tissue and the bone marrow. Ectopic fat accrual contributes to organ dysfunction, systemic insulin resistance, and other perturbations that have been implicated in metabolic diseases.This research proposal aims to identify the regulatory cues that control the d ...
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2
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TERMINÉ
Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - The FRAILOMIC Initiative (FRAILOMIC)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
The forecasted increase in the number of older people for this century will be accompanied by an increase of those with disabilities. Disability is usually preceded by a condition named frailty that encompasses changes associated with ageing, life styles and chronic diseases. To detect and intervene on it is of outstanding importance to prevent disability, as recovery from disability is unlikely. ...
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29
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TERMINÉ
Synthetic Cellular Signaling Circuits (SynSignal)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,
Cellular signaling systems are crucially important for a broad range of critical health and disease areas and high value industrial applications. Signaling systems are the target for more than half of the medicines marketed by the pharmaceutical industry, and form the main R&D area for the nutrition, flavour and fragrance industries. SynSignal is a multidisciplinary high-tech consortium working in ...
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10
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TERMINÉ
Global initiative on gene-environment interaction on diabetes/obesity risk (InterConnect)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
The overall goal of InterConnect is to establish a global network that will facilitate the co-ordination of population research on the interaction between genetic and environmental factors in the aetiology of obesity and diabetes. We aim to establish mechanisms for identification and classification of studies and the data that they hold and create a forum for harmonization of methods as a foundati ...
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12
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TERMINÉ
Rheumatoid Arthritis and Periodontal Inflammatory Disease (RAPID) (RAPID)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,
"The most prevalent chronic inflammatory diseases of humans are complex disorders of multifactorial aetiology influenced by genes, the environment and their interactions. Periodontitis (PD) and rheumatoid arthritis (RA) are two such chronic inflammatory diseases associated withsignificant morbidity and mortality, and have recently shown to have a bi-directional association. Moreover, the prevalenc ...
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15
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TERMINÉ
EPIC-CVD: Individualised CVD risk assessment: tailoring targeted and cost-effective approaches to Europe's diverse populations (EPIC-CVD)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
"EPIC-CVD's overarching goal is to provide clinicians and policy-makers with a menu of evidence-based options for cost-effective individualised risk assessment that enables the EU's increasingly resource-constrained economies to achieve more personalised predictive medicine in harmony with Europe's diverse cultures and healthcare systems.We will achieve this through developing and validating innov ...
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33
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TERMINÉ
Type 2 diabetes and obesity among sub-Saharan African native and migrant populations: dissection of environment and endogenous predisposition (RODAM)
Date du début: 1 janv. 2012, Date de fin: 30 sept. 2015,
"Migration from Sub-Saharan Africa (SSA) to Europe is increasing. The limited evidence suggests that the risk of type 2 diabetes (T2D) and obesity among SSA migrants is higher than among their SSA peers living in Africa and European host populations. The reasons for these observations are only poorly understood, but may involve migration-related changes in lifestyle, genetic predisposition as well ...
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9
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TERMINÉ
Role of human papillomavirus infection and other co-factors in the aetiology of head and neck cancer in India and Europe (HPV-AHEAD)
Date du début: 1 sept. 2011, Date de fin: 31 août 2015,
Human papillomavirus (HPV) is responsible for approximately 25% of head and neck cancer (HNC) worldwide and appears to be associated with a better response to treatment and improved prognosis. Evidence suggests that HPV-induced HNC has steadily increased in the USA and some European countries in the last decades. However, whether this is a worldwide phenomenon and specific risk factors are associa ...
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11
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TERMINÉ
BIOmarkers of Robustness of Metabolic Homeostasis for Nutrigenomics-derived Health CLAIMS Made on Food (BIOCLAIMS)
Date du début: 1 mars 2010, Date de fin: 28 févr. 2015,
The food and health relationship focuses on maintenance of optimal health, both in terms of physiology and new European legislation. Yet, most accepted biomarkers quantify (intermediate) disease endpoints or damage. This has led to major problems in demonstrating health benefits and establishing health claims, and blocks competitive economic and health developments in the food sector. BIOCLAIMS de ...
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11
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TERMINÉ
Molecular Targets Open for Regulation by the gut flora – New Avenues for improved Diet to Optimize European health (TORNADO)
Date du début: 1 sept. 2009, Date de fin: 31 août 2014,
"Europe is facing major diet related health problems. Attitudes to eating habits have to be changed and the benefits of alternative treatment regimes substantiated. This can only be achieved by providing guidelines regulating health claims based on scientific data. Thus, there is a unique opportunity to use gut flora in potential treatment regimes and as a preventive target for major diet related ...
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24
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TERMINÉ
European Obesity Consortium studying the Hypothalamus and its Interaction with Peripheral organs (EurOCHIP)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,
The past decade has seen tremendous progress in our understanding of homeostatic regulators controlling energy balance. Insights from human and murine genetics have illuminated multiples pathways within the hypothalamus, brainstem and higher brain regions that play a key role in the control of food intake, whilst physiological studies focusing on the gastrointestinal tract have revealed a panoply ...
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