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 TERMINÉ 

EURO EWING Consortium – International Clinical Trials to Improve Survival from Ewing Sarcoma (EEC)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Ewing Sarcomas (ES) are fatal, rare bone cancers particularly affecting young people. About 60% of patients achieve long term survival with current treatment but there has been no improvement in this proportion for 25 years. Treatment is unsuccessful because chemotherapy fails to prevent the development of, or to effectively treat established, metastases. In addition, of the 600 new cases of ES o ...
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 21

 TERMINÉ 

Electrical Control of Cell Polarization (ECCP)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2017,

"Cell polarization describes the ability of a cell to use external and/or internal stimuli to decide in which direction to grow, crawl or divide. Cells can sense different cues in vivo such as chemical gradients, sites of cell adhesion, and electric fields. In this proposal, we aim at investigating the electrical aspects of cell polarization. Endogenous electrical signals are present around tissue ...
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 2

 TERMINÉ 

Epidemiological study to quantify risks for paediatric computerized tomography and to optimise doses (EPI-CT)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2017,

Diagnostic radiation represents an indispensable, sometimes life-saving, tool in modern medicine. However, the growing use of computerized tomography (CT) is a topic of concern in radiological protection, especially for children and adolescents. Children are generally more sensitive to the carcinogenic effects of ionizing radiation than adults. In addition, they have a longer life-span to express ...
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 22

 TERMINÉ 

The role of the influenza virus matrix protein M1 in budding adn virus release (FLUMABUD)

Date du début: 1 mars 2013, Date de fin: 29 janv. 2017,

Enveloped viruses, such as influenza, acquire their outer lipid envelope by budding from the membrane of the infected host before being released in the extra-cellular space by membrane fission. In these last steps of the virus infection cycle, matrix proteins connecting capsid with the lipid envelope often play a key role in assembly and budding of newly produced virions. In spite of the widely ac ...
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 1

 TERMINÉ 

Rational Therapy for Breast Cancer: Individualized Treatment for Difficult-to-Treat Breast Cancer Subtypes (RATHER)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2016,

"Cancer genotyping has identified a number of correlations between mutations in specific genes and responses to targeted anti-cancer drugs, with many mutations occurring in kinases or downstream signaling components. While there are several ongoing large-scale genome re-sequencing studies for the major cancer types, there is no systematic effort to investigate kinase mutations in distinct biologic ...
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 8

 TERMINÉ 

A European Platform for Translational Cancer Research (EUROCANPLATFORM)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2016,

Europe has a number of advantages as regards developing translational cancer research, yet there is no clear European strategy to meet the increasing burden posed by cancer. The FP6 Eurocan+Plus project analysed the barriers underlying the increasing fragmentation of cancer research and stressed the need to improve collaboration between basic/preclinical and comprehensive cancer centres (CCCs), in ...
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 29

 TERMINÉ 

The mechanics and transport of the active cytoskeleton in biomimetic and living cellular systems (Biomimetic-Mechanics)

Date du début: 1 sept. 2014, Date de fin: 31 août 2016,

Intracellular transport involves movement of molecules and organelles through the subcellular environment and is critical for proper cell function. It can be driven by molecular motors or by cytoskeletal fluctuations and flow of the cytoplasm. Transport plays an integral role in many cellular functions, including migration and division, which are intimately linked to the metastatic spread of cance ...
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 1

 TERMINÉ 

Systems biology of liver cancer: an integrative genomic-epigenomic approach (MODHEP)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2016,

"Cancer is a complex disease involving multiple genetic and epigenetic events occurring, and influencing each other, over a long period of time. Understanding cancer, and ultimately developing effective targeted therapies, will therefore require that mutations and epigenetic alterations be systematically investigated during the multiple stages of disease development, from identifiable pre-neoplast ...
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 18

 TERMINÉ 

ASSET: Analysing and Striking the Sensitivities of Embryonal Tumours (ASSET)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2016,

Cancer is hallmarked by multiple genetic aberrations that lead to a functional derangement of cellular signalling networks. Embryonal tumours (ETs) comprising neuroblastoma, medulloblastoma and Ewing sarcoma, occur early in life, and thus may reveal pathogenetically relevant lesions clearer than adulthood tumours which carry passenger mutations accumulated during life. ASSET will exploit this fact ...
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 20

 TERMINÉ 

High Throughput Multimodal Microfluidic Sorting and Biological Analysis of Circulating Tumour Cells (HISOCELL)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2016,

There is today a huge interest in the clinical community regarding circulating tumour cells (CTC), as easy and minimally invasive « liquid biopsies ». They should provide, during the « blind » period following primary treatment of a cancer, a powerful tool to evaluate the risk of metastatic development, to follow in real time the efficiency of treatments, and guide clinicians in the prescription o ...
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 1

 TERMINÉ 

Epigenetics towards systems biology (EPIGENESYS)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2016,

The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is nee ...
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 28

 TERMINÉ 

Reconstitution of Myosin IIA-driven membrane fission in vitro (MYOII-DRIVEN FISSION)

Date du début: 1 mars 2014, Date de fin: 29 févr. 2016,

Eukaryotic cells contain a variety of membrane-enclosed compartments that are connected by dynamic transport processes facilitated by vesicles. The temporal and spatial regulation of these transport processes is essential for cellular function. After initial formation transport vesicles are separated from their donor membrane and this fission event seems to be coordinated with the elongation of tu ...
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 1

 TERMINÉ 

Love wave fully integrated Lab-on-Chip platform for food pathogen detection (LOVE-FOOD)

Date du début: 1 sept. 2012, Date de fin: 29 févr. 2016,

The project is aimed at developing a fully integrated lab-on-chip microsystem platform, performing multimodal analysis of several analytes combining nucleic acid and whole bacteria detection. The system will allow directly and without prior culture the identification in one single run of a multiplicity of pathogens and their specific sequences responsible will be targeted and identified. The heart ...
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 8

 TERMINÉ 

Low Dose Research towards Multidisciplinary Integration (DOREMI)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2015,

The aim of DoReMi is to promote the sustainable integration of low dose risk research in Europe in order to aid the effective resolution of the key policy questions identified by the High Level Expert Group (HLEG) on Low Dose Risk Research (www.hleg.de). DoReMi provides an operational tool for the development of the proposed MELODI platform (Multidisciplinary European Low Dose Risk Re-search Initi ...
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 39

 TERMINÉ 

Epigenetic challenges in centromere inheritance during the cell cycle (Eccentric)

Date du début: 1 juin 2010, Date de fin: 31 déc. 2015,

Studies concerning the mechanism of DNA replication have advanced our understanding of genetic transmission through multiple cell cycles. Recent work has shed light on possible means to ensure the stable transmission of information beyond just DNA and the concept of epigenetic inheritance has emerged. Considering chromatin-based information, key candidates have arisen as epigenetic marks including ...
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 1

 TERMINÉ 

Atoh1/Math1 regulation and function during cerebellar normal development and medulloblastoma (Atoh1Medullo)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

"Atoh1, a proneural basic helix-loop-helix transcription factor is required for cerebellar development. My recent studies using loss or gain of function uncovered a critical role for Atoh1 in medulloblastoma (MB) development, the most common malignant pediatric tumor of the cerebellum. As a junior group leader, I develop a research program at the Institute Curie in the new department of ""Signalin ...
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 1

 TERMINÉ 

Spatio-temporal regulation of antigen presentation and cell migration (STRAPACEMI)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2015,

"The immune system is constituted by different cell populations, which circulate between lymphoid organs and peripheral tissues as a result of their high migratory capacity. We have shown that Antigen (Ag) processing and migration of Ag Presenting Cells (APCs) are co-regulated by a protein complex that contains the MHC class II-associated Invariant Chain (Ii) and the actin-based motor protein Myos ...
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 1

 TERMINÉ 

Dissecting the role of BRCA2 in the DNA damage response and exploiting its parts for anticancer therapy (Dissecting BRCA2)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

Mutations in the tumor suppressor gene, BRCA2, cause susceptibility to breast and ovarian cancer. BRCA2 protein is required for homologous recombinational DNA repair (HRR), the predominant mechanism employed by cells to accurately repair DNA double-stranded breaks (DSBs). In humans, the central player of the HRR process is RAD51; it catalyzes the DNA strand exchange that results in the repaired DN ...
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 1

 TERMINÉ 

Epigenetic regulation and monoallelic gene expression: the X-inactivation paradigm and beyond (EpigenetiX)

Date du début: 1 mai 2010, Date de fin: 31 oct. 2015,

X-chromosome inactivation (XCI) represents a classic example of epigenetics in mammals. In this process, one of the two X chromosomes in females is converted from an active into a clonally heritable, inactive, state during early embryonic development, to ensure dosage compensation between the sexes. This process is also remarkable in that an entire chromosome is silenced while its homologue, prese ...
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 1

 TERMINÉ 

HEMatopoietic cell IDentity : genetic and epigenetic regulation in normal and malignant hematopoiesis (HEM_ID)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

In hematopoiesis, failure to maintain homeostasis and regenerative functions result in a multitude of hematological malignancies, including myelodysplastic syndromes, lymphomas and leukemias, that represent a medical challenge and a large socioeconomic burden because of the large number of affected patients of all age groups. Although hierarchical organization of the hematopoietic system has been ...
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 12

 TERMINÉ 

MKlp2 - a mitotic kinesin and a prime target for cancer therapy (MKlp2-mitosis)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2015,

Mklp2, a mitotic kinesin and a prime target for cancer therapyMKlp2 belongs to kinesin 6 family and was first identified as an effector protein of small G protein Rab6A, involving in the retrograde transport between Golgi and ER. While its function in Golgi-ER trafficking awaits further study, MKlp2 has been shown to play crucial role in mitosis. It is essential to relocate chromosomal passenger p ...
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 1

 TERMINÉ 

Chromatin Dynamics In Genome Integrity (ChroDIGI)

Date du début: 1 sept. 2011, Date de fin: 31 août 2015,

I have developed a research program that focuses on the role of chromatin in epigenetic inheritance and genome integrity. I am pursuing three lines of research both in the model organism S.cerevisiae and in human cells: First, I am exploring the role of chromatin regulatory factors in eukaryotic DNA replication. S phase is a precarious phase in the cell cycle and chromosome stability and subsequen ...
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 1

 TERMINÉ 

A Direct Role for Nucleosome Turnover in Polycomb Response Element Function (REPLACOMB)

Date du début: 1 sept. 2012, Date de fin: 31 août 2015,

"Polycomb group (PcG) and Trithorax group (TrxG) proteins are essential for maintaining different cell identities through chromatin-based regulation of gene expression during development. A crucial aspect of this system is the competition of PcG and TrxG proteins for cis-regulatory DNA elements called Polycomb Response Elements (PREs). However, the mechanisms underlying this competition remain lar ...
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 1

 TERMINÉ 

Nanosystems for the early Diagnosis of Neurodegenerative diseases (NADINE)

Date du début: 1 sept. 2010, Date de fin: 31 août 2015,

Medical diagnosis is currently undergoing a major revolution due to the fast discovery of molecular biomarkers, and the development of multimodal “metabiomarker” signatures. Progress, however, is hindered by low abundance of many biomarkers of interest in body fluids, in absolute concentration and with regard to other biomolecules. The aim of the present project is to apply these progresses in bio ...
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 19

 TERMINÉ 

Investigating the link between centrosomes, stem cells and cancer (CENTROSTEMCANCER)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,

Centrosomes are cytoplasmic organelles found in most animal cells with important roles in polarity establishment and maintenance. Theodor Boveri s pioneering work first suggested that extra-centrosomes could contribute to genetic instability and consequently to tumourigenesis. Although many human tumours do exhibit centrosome amplification (extra centrosomes) or centrosome abnormalities, the exact ...
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 1

 TERMINÉ 

In vivo analysis of DISC1 function in synaptogenesis and axonal transport (DISC1 & Axogenesis)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,

Schizophrenia is a highly hereditable psychological disease that affects up to 1% of the world population. This pathology causes devastating neurological symptoms. A great advance in understanding the basic biological processes affected in schizophrenia came from the discovery of some of the genes that when mutated represent a risk factor for the development of the disease, most likely acting in c ...
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 1

 TERMINÉ 

Microbes in Allergy and Autoimmunity Related to the Skin (MAARS)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,

"Allergy and autoimmunity cause increasing burden to societies worldwide. We study the effect of microbiome on the skin, the forefront barrier to environment, on autoimmunity and allergy, using atopic dermatitis (AD) and psoriasis (PSO) as paradigmatic examples. We have detailed information about the genetic risk factors, as well as the molecular and cellular players in AD and PSO, but we know ver ...
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 10

 TERMINÉ 

TreatPolyQ – Industrial Academic Initial Training Network towards treatment of Polyglutamine Diseases (TREATPOLYQ)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

Protein aggregation is a hallmark of many late onset neurodegenerative disorders including Parkinson’s Disease (PD), Alzheimer’s Disease (AD), amyotrophic lateral sclerosis (ALS), prion diseases as well as the group of polyglutamine diseases (polyQ). The aim of this proposal is to create a network of European partners bridging important basic mechanisms involved in proteinopathies, research of mod ...
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 17

 TERMINÉ 

The mechanism of retrograde trafficking by retromer (Retromer)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

Transportation of proteins and lipids between membrane-enclosed organelles by vesicle formation is a fundamental task in eukaryote cells. The least understood protein complex involved in membrane remodelling for vesiculation, but with a wide range of medical implications, is the retromer complex.The objective of this proposal is:First, to identify the mechanistic principles of membrane bending and ...
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 1

 TERMINÉ 

The Polycomb Repression Complex 2 (PRC2): Mechanisms of recruitment and role in tumorigenesis (PReMORRIT)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

"A key to development is the maintenance of various cell identities. Despite identical genome sequence, in a defined organism, cells from different origins will have distinct pattern of gene expression. The chromatin structure plays a pivotal role in the regulation of gene expression and contributes to this so-called ""epigenetic information"". Different parameters defined the chromatin structure ...
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 1

 TERMINÉ 

EUROCANCER STEMCELL TRAINING NETWORK (EuroCSCTraining)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

The recent identification of tumor initiating (TIC) or cancer stem cells (CSC) has opened a new area of research for scientists interested in cancer. Understanding the biology of cancer stem cells has already unraveled pathways and potential targets. However, accumulating data has underscored the complexity of the CSC research area and prompts hence the need for well-structured networks to provid ...
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 11

 TERMINÉ 

Transport and signalling in Polarized Cells (TRANSPOL)

Date du début: 1 déc. 2010, Date de fin: 30 nov. 2014,

"Aberrant molecular signalling and intracellular trafficking are the molecular cause of many human diseases. TRANSPOL is an interdisciplinary initial stage training network (ITN) at the intersection of cell/molecular biology and membrane physics aimed specifically at the molecular understanding of the functional relationship between intracellular trafficking and cellular signalling and their relev ...
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 11

 TERMINÉ 

Tools for minimally invasive diagnostics (DiaTools)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2014,

A new generation of molecular tools is becoming available that can digitally record numbers, identities and locations of a broad range of molecular markers for increased diagnostic accuracy. This project will for the first time combine synergistically several groundbreaking technological innovations by the partners, notably padlock and proximity probes with rolling circle amplification for single ...
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 8

 TERMINÉ 

Toward an HIV-1 vaccine: Molecular mechanisms regulating the cryptic innate immune response to HIV-1 (HIV innate immunity)

Date du début: 1 oct. 2010, Date de fin: 30 sept. 2014,

Our goal is to understand the innate immune response to HIV-1. We have found that a cryptic innate immune response to HIV-1 exists in dendritic cells (DC). This response is normally inactive because HIV-1 is unable to infect DC. We have used the Vpx protein found in other lentiviruses to render DC susceptible to HIV-1 infection. The resulting innate response to HIV-1 requires an interaction betwee ...
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 1

 TERMINÉ 

Integrative phagosomal biology: antigen presentation and developmental programs in dendritic cells (PhagoDC)

Date du début: 1 juil. 2009, Date de fin: 30 juin 2014,

Integrative phagosomal biology: antigen presentation and developmental programs in dendritic cells Dendritic cells phagocytose incoming pathogens and dead cells in peripheral tissues, and then migrate to the draining lymph nodes where they deliver to lymphocytes all the information required for the initiation of adaptive immune responses. This information relates to the nature of the pathogen, ...
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 1

 TERMINÉ 

A novel role for histone chaperones in the dynamics of non-conventional substrates, the CENP-T/-W, complex at the centromere (CenHFDC)

Date du début: 1 mars 2012, Date de fin: 20 juin 2014,

Two essential phases exist in centromere assembly and maturation during the cell cycle; a G1 phase in which CENP-A is replenished to establish replication competent centromeres and a late-S/G2 phase, in which additional assembly events establish a centromeric substrate competent for kinetochore assembly. The centromere provides a unique context in which to examine the question of epigenetic inheri ...
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 1

 TERMINÉ 

Compartmentalization and dynamics of Nuclear functions (CDNF)

Date du début: 1 sept. 2008, Date de fin: 31 mai 2014,

The eukaryotic genome is packaged into large-scale chromatin structures that occupy distinct domains in the nucleus and this organization is now seen as a key contributor to genome functions. Two key functions of the genome can take advantage of nuclear organization: regulated gene expression and the propagation of a stable genome. To understand these fundamental processes, we have chosen to use y ...
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 1

 TERMINÉ 

Identification of Rab GTPase cascades in the post-Golgi trafficking of mammalian cells (Rab GTPase cascades)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2014,

Throughout the last thirty years, research on Rab GTPase proteins has brought light to their pivotal role in the regulation of several steps of intracellular trafficking. However, recent findings indicate that Rab proteins not only regulate individual transport steps, but they also function in a coordinated fashion in Rab GTPase cascades. Such cascades appear to be crucial for orchestrating seque ...
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 1

 TERMINÉ 

Nucleosome Structure & Function across Biological Scales and Biological Function (NUCLEOSOME4D)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,

Chromatin packages a few meters of DNA into a nucleus measuring a few microns. This tight folding occurs by assembling DNA with histones into so-called nucleosomes, thus ensuring the mechanical stability of our genome. On the flipside, this makes nucleosomes a formidable obstacle to the machines that read, copy or repair its DNA message. One of the fundamental questions in biology is to understand ...
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 17

 TERMINÉ 

Spatio-temporal Control of Cell Division in Fission Yeast (SpTpCdr2)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2013,

Cytokinesis is a critical and irreversible step of cell cycle, which eventually separates daughter cells. This event is consequently subject to strict spatial and temporal regulations. Spatial integration of the DNA distribution and the global geometry of the cell are necessary to determine the proper division plane and ensure the successful genome and cytoplasmic segregation. Additionally, cells ...
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 1