5 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Early Prevention of Diabetes Complications in people with Hyperglycaemia in Europe (E-PREDICE)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,
"Background: A significant proportion of pre-diabetics, show macro and micro vascular complications associated with hyperglycaemia. Although many trials have demonstrated the efficacy of lifestyle and pharmaceutical interventions in diabetes prevention, no trial has evaluated the extent to which mid- and long-term complications can be prevented by early interventions on hyperglycaemia.Aims: To ass ...
Voir le projet
37
Participants partenaires
TERMINÉ
Safety Evaluation of Adverse Reactions in Diabetes (SAFEGUARD)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,
"In 2010 a widely marketed drug for the treatment of type 2 diabetes (T2DM) (rosiglitazone) was taken from the market as it was associated with an increased risk of myocardial infarction, a T2DM complication it was actually supposed to prevent. This example shows several things. First, the approval requirements do not guarantee a longer term positive benefit risk profile. Second, large scale postm ...
Voir le projet
19
Participants partenaires
TERMINÉ
Tissue Transmigration Training Network (T3Net)
Date du début: 1 sept. 2009, Date de fin: 31 août 2013,
Cardiovascular and cancer-related diseases are the leading causes of human mortality and disability. The underlying mechanisms originate from chronic interstitial cell activation leading to pathological tissue remodelling and malfunction of cells. These depend on three fundamental processes: cell adhesion, migration, and modulation/degradation of the extracellular matrix (ECM), which together dete ...
Voir le projet
8
Participants partenaires
TERMINÉ
Lipid droplets as dynamic organelles of fat deposition and release: Translational research towards human disease (LipidomicNet)
Date du début: 1 mai 2008, Date de fin: 31 oct. 2012,
Lipids are central to the regulation and control of cellular processes by acting as basic building units for biomembranes, the platforms for the vast majority of cellular functions. Recent developments in lipid mass spectrometry have set the scene for a completely new way to understand the composition of membranes, cells and tissues in space and time by allowing the precise identification and quan ...
Voir le projet
27
Participants partenaires
TERMINÉ
"Pathophysiology of rare diseases due to ciliary dysfunction: nephronophthisis, Oral-facial-digital type 1 and Bardet-Biedl syndromes" (EUCILIA)
Date du début: 1 févr. 2008, Date de fin: 31 janv. 2011,
"Primary cilia have been recognized on nearly all-mammalian cells. Emerging data suggest that they act as cellular antennae with diverse motility and sensory functions, detecting a wide variety of signals. As such, defects in cilia formation or function have profound effects on the development of body pattern and the physiology of multiple organ systems. Ciliary defects underlie a wide range of hu ...
Voir le projet